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Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 691979, updated on 2-Nov-2024

Summary

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Official Symbol
Esco2provided by RGD
Official Full Name
establishment of sister chromatid cohesion N-acetyltransferase 2provided by RGD
Primary source
RGD:1593313
See related
EnsemblRapid:ENSRNOG00000015921 AllianceGenome:RGD:1593313
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable lysine N-acetyltransferase activity, acting on acetyl phosphate as donor and peptide-lysine-N-acetyltransferase activity. Predicted to be involved in mitotic sister chromatid cohesion; post-translational protein acetylation; and regulation of DNA replication. Predicted to act upstream of or within several processes, including double-strand break repair; hematopoietic progenitor cell differentiation; and protein localization to chromatin. Predicted to be located in several cellular components, including Golgi apparatus; chromocenter; and chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Roberts syndrome and lung adenocarcinoma. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 170.8), Spleen (RPKM 126.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Esco2 in Genome Data Viewer
Location:
15p12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (44210124..44230785, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (40034566..40052295, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (42500929..42519019, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene scavenger receptor class A, member 5 Neighboring gene uncharacterized LOC108352941 Neighboring gene uncharacterized LOC134482136 Neighboring gene PDZ binding kinase Neighboring gene coiled-coil domain containing 25 Neighboring gene NOP53 ribosome biogenesis factor, pseudogene 1 Neighboring gene uncharacterized LOC134482135

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Prenatal diagnosis of Roberts syndrome and detection of an ESCO2 frameshift mutation in a Pakistani family. Schulz S, et al. Prenat Diagn, 2008 Jan. PMID 18186147
  2. ESCO2 promotes lung adenocarcinoma progression by regulating hnRNPA1 acetylation. Zhu HE, et al. J Exp Clin Cancer Res, 2021 Feb 11. PMID 33573689, Free PMC Article
  3. The non-redundant function of cohesin acetyltransferase Esco2: some answers and new questions. Whelan G, et al. Nucleus, 2012 Jul 1. PMID 22614755
  4. Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Vega H, et al. Nat Genet, 2005 May. PMID 15821733
  5. Upregulation of KAT2B and ESCO2 gene expression level in patients with rheumatoid arthritis. Ghasemi A, et al. Clin Rheumatol, 2023 Jan. PMID 36104638

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptide-lysine-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-translational protein acetylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in XY body ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromocenter ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-acetyltransferase ESCO2
XP_003751543.1
XP_063130952.1
XP_063130953.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001433103.1 → NP_001420032.1  N-acetyltransferase ESCO2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

  2. NM_001433107.1 → NP_001420036.1  N-acetyltransferase ESCO2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    44210124..44230785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274882.1 → XP_063130952.1  N-acetyltransferase ESCO2

    Related
    ENSRNOP00000068247.1, ENSRNOT00000076451.4

  2. XM_063274883.1 → XP_063130953.1  N-acetyltransferase ESCO2

    UniProtKB/TrEMBL
    A0A096MJS9, A6K6K6

  3. XM_003751495.6 → XP_003751543.1  N-acetyltransferase ESCO2

    Conserved Domains (2) summary
    pfam13878
    Location:374 → 413
    zf-C2H2_3; zinc-finger of acetyl-transferase ESCO
    pfam13880
    Location:523 → 591
    Acetyltransf_13; ESCO1/2 acetyl-transferase
Nucleotide Protein Strain
Heading Accession and Version

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