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Naxd NAD(P)HX dehydratase [ Mus musculus (house mouse) ]

Gene ID: 69225, updated on 2-Nov-2024

Summary

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Official Symbol
Naxdprovided by MGI
Official Full Name
NAD(P)HX dehydrataseprovided by MGI
Primary source
MGI:MGI:1913353
See related
Ensembl:ENSMUSG00000031505 AllianceGenome:MGI:1913353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Carkd; 0710008K08Rik; 2810407E01Rik
Summary
Predicted to enable ATP-dependent NAD(P)H-hydrate dehydratase activity. Predicted to be involved in metabolite repair. Located in cytosol; endoplasmic reticulum; and mitochondrion. Is expressed in metanephros. Orthologous to human NAXD (NAD(P)HX dehydratase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 54.6), lung adult (RPKM 48.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Naxd in Genome Data Viewer
Location:
8 A1.1; 8 5.73 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11547506..11563287)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (11497506..11513287)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene collagen, type IV, alpha 2 Neighboring gene predicted gene 15419 Neighboring gene STARR-positive B cell enhancer ABC_E8227 Neighboring gene RIKEN cDNA E230013L22 gene Neighboring gene RAB20, member RAS oncogene family Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:11550723-11550832 Neighboring gene STARR-seq mESC enhancer starr_20716 Neighboring gene STARR-positive B cell enhancer ABC_E9718 Neighboring gene STARR-positive B cell enhancer ABC_E2856 Neighboring gene STARR-positive B cell enhancer ABC_E1101 Neighboring gene inhibitor of growth family, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Occurrence and subcellular distribution of the NADPHX repair system in mammals. Marbaix AY, et al. Biochem J, 2014 May 15. PMID 24611804
  2. A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34. Vats KR, et al. J Am Soc Nephrol, 2006 Apr. PMID 16565260
  3. Characterization of the zinc-induced Shank3 interactome of mouse synaptosome. Lee Y, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29111324
  4. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
  5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 0710008K08Rik, 2810407E01Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent NAD(P)H-hydrate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent NAD(P)H-hydrate dehydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in metabolite repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nicotinamide nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ATP-dependent (S)-NAD(P)H-hydrate dehydratase
Names
ATP-dependent NAD(P)HX dehydratase
carbohydrate kinase domain containing
carbohydrate kinase domain-containing protein
NP_001177286.1
NP_001280590.1
NP_001389565.1
NP_081271.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190357.1 → NP_001177286.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 2

    See identical proteins and their annotated locations for NP_001177286.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon in the 5' UTR and 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2) with a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK012456, BC030080, BY270677
    Consensus CDS
    CCDS57604.1
    UniProtKB/Swiss-Prot
    Q9CQX9, Q9CZ42, Q9D7G7, Q9DC93
    UniProtKB/TrEMBL
    J3QMM7
    Related
    ENSMUSP00000136363.2, ENSMUST00000177955.8
    Conserved Domains (1) summary
    cd01171
    Location:49 → 316
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

  2. NM_001293661.1 → NP_001280590.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame exon in the 5' UTR and 5' coding region and lacks an alternate coding exon in the 3' end compared to variant 1. This results in a shorter protein (isoform 2) with distinct N- and C-termini compared to isoform 1.
    Source sequence(s)
    BC030080, BY270677, DV045296
    Consensus CDS
    CCDS80857.1
    UniProtKB/TrEMBL
    J3QN06
    Related
    ENSMUSP00000136535.2, ENSMUST00000178721.2
    Conserved Domains (1) summary
    cd01171
    Location:49 → 237
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

  3. NM_001402636.1 → NP_001389565.1  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124475

  4. NM_026995.4 → NP_081271.2  ATP-dependent (S)-NAD(P)H-hydrate dehydratase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC124475, AK013028, BC030080, BY254286
    Consensus CDS
    CCDS22096.2
    UniProtKB/Swiss-Prot
    Q9CQX9, Q9CZ42, Q9D7G7, Q9DC93
    UniProtKB/TrEMBL
    K3W4M4
    Related
    ENSMUSP00000033901.5, ENSMUST00000033901.11
    Conserved Domains (1) summary
    cd01171
    Location:87 → 354
    YXKO-related; B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    11547506..11563287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZ42.1 GenPept UniProtKB/Swiss-Prot:Q9CZ42

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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