Gtpbp4 GTP binding protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gtpbp4provided by MGI
Official Full Name: GTP binding protein 4provided by MGI
Primary source: MGI:MGI:1916487
See related: Ensembl:ENSMUSG00000021149 AllianceGenome:MGI:1916487
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NGB; Crfg; Nog1; Gtpbp3; 2610028C09Rik
Summary: Predicted to enable several functions, including GTP binding activity; GTPase activity; and preribosome binding activity. Acts upstream of or within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in cytosol; nucleus; and perinuclear region of cytoplasm. Predicted to be active in nucleolus. Orthologous to human GTPBP4 (GTP binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 17.1), placenta adult (RPKM 10.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A1; 13 3.64 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (9016039..9046080, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (8972070..8996116, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NOG1 downregulates type I interferon production by targeting phosphorylated interferon regulatory factor 3.
Title: NOG1 downregulates type I interferon production by targeting phosphorylated interferon regulatory factor 3.
These results suggest that conformational changes in the switch II element of Nog1 have a critical importance for the dissociation of preribosome-bound factors during intranucleolar maturation.
Title: Restricting conformational flexibility of the switch II region creates a dominant-inhibitory phenotype in Obg GTPase Nog1.
Resonance Raman spectroscopy was used to determine the structure of the heme environment in Ngb from mice.
Title: The heme environment of mouse neuroglobin. Evidence for the presence of two conformations of the heme pocket.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISS Inferred from Sequence or Structural Similarity more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables preribosome binding	ISO Inferred from Sequence Orthology more info
enables preribosome binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of collagen binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen binding	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: GTP-binding protein 4

Names: GTP binding protein 3; GTP-binding protein NGB; Nucleolar GTP-binding protein 1 (Chronic renal failure gene protein) (GTP-binding protein NGB); chronic renal failure gene protein; chronic renal failure protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418602.1 → NP_001405531.1 GTP-binding protein 4 isoform 2

Status: VALIDATED

Source sequence(s)

AC124732, AC125484
NM_001418603.1 → NP_001405532.1 GTP-binding protein 4 isoform 3

Status: VALIDATED

Source sequence(s)

AC124732, AC125484
NM_001418604.1 → NP_001405533.1 GTP-binding protein 4 isoform 4

Status: VALIDATED

Source sequence(s)

AC124732, AC125484
NM_001418605.1 → NP_001405534.1 GTP-binding protein 4 isoform 5

Status: VALIDATED

Source sequence(s)

AC124732, AC125484
NM_001418606.1 → NP_001405535.1 GTP-binding protein 4 isoform 6

Status: VALIDATED

Source sequence(s)

AC124732, AC125484
NM_001418607.1 → NP_001405536.1 GTP-binding protein 4 isoform 7

Status: VALIDATED

Source sequence(s)

AC124732, AC125484
NM_027000.5 → NP_081276.2 GTP-binding protein 4 isoform 1

See identical proteins and their annotated locations for NP_081276.2

Status: VALIDATED

Source sequence(s)

AC124732, AC125484

Consensus CDS

CCDS26236.1

UniProtKB/Swiss-Prot

Q99K16, Q99ME9, Q99P78, Q9CT02

Related

ENSMUSP00000152412.2, ENSMUST00000222098.2

Conserved Domains (3) summary

cd01897
Location:169 → 340

NOG; Nucleolar GTP-binding protein (NOG)

COG1084
Location:5 → 345

Nog1; GTP-binding protein, GTP1/Obg family [General function prediction only]

pfam08155
Location:396 → 446

NOGCT; NOGCT (NUC087) domain