ELOA elongin A [Homo sapiens (human)] - Gene

Summary

Official Symbol: ELOAprovided by HGNC
Official Full Name: elongin Aprovided by HGNC
Primary source: HGNC:HGNC:11620
See related: Ensembl:ENSG00000011007 MIM:600786; AllianceGenome:HGNC:11620
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIII; ELOA1; TCEB3; TCEB3A; SIII p110
Summary: This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lung (RPKM 15.9), thyroid (RPKM 14.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (23743471..23762059)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (23578438..23597030)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (24069961..24088549)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1.
Title: TCEB3 initiates ovarian cancer apoptosis by mediating ubiquitination and degradation of MCL-1.
Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.
Title: Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity.
the Elongin A ubiquitin ligase and the CSB protein function together in a common pathway in response to Pol II stalling and DNA damage
Title: Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage.
TCEB3C is a putative tumor suppressor gene of small intestinal neuroendocrine tumors
Title: TCEB3C a putative tumor suppressor gene of small intestinal neuroendocrine tumors.
Elongin A transcription elongation activity, but not its ubiquitination activity, is most important for its function in induction of transcription of ATF3 and p21.
Title: Transcriptional properties of mammalian elongin A and its role in stress response.
Observational study of gene-disease association. (HuGE Navigator)
Title: The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of transcription elongation factor B (SIII), polypeptide 3 (TCEB3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells	PubMed
Knockdown of transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A; TCEB3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef expression in HeLa cells upregulates transcription elongation factor B (SIII; elongin A) expression	PubMed
Tat	tat	The C-terminal 34 residues (1329-1362) of BRD4 are crucial for interaction with P-TEFb. Overexpression of the BRD4 P-TEFb-interacting domain disrupts the interaction between HIV-1 Tat and P-TEFb	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-74402 (e-PCR)
- UniSTS:4870

SGC35583 (e-PCR)
- UniSTS:3366

D8S2279 (e-PCR)
- UniSTS:473907

D10S2448 (e-PCR)
- UniSTS:474444

RH48114 (e-PCR)
- UniSTS:63578

G38154 (e-PCR)
- UniSTS:53341

SHGC-33880 (e-PCR)
- UniSTS:33120

RH65778 (e-PCR)
- UniSTS:15218

D16S325 (e-PCR)
- UniSTS:147089

SHGC-144848 (e-PCR)
- UniSTS:172457

SHGC-74400 (e-PCR)
- UniSTS:69298

RH93681 (e-PCR)
- UniSTS:87019

RH69057 (e-PCR)
- UniSTS:46329

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of elongin complex	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	HDA more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in site of DNA damage	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: elongin-A

Names: RNA polymerase II transcription factor SIII subunit A1; elongin 110 kDa subunit; transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A); transcription elongation factor B alpha subunit; transcription elongation factor B polypeptide 3; transcription elongation factor B subunit 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003198.3 → NP_003189.3 elongin-A

Status: REVIEWED

Source sequence(s)

AL031295

Consensus CDS

CCDS239.3

UniProtKB/Swiss-Prot

B2R7Q8, Q14241, Q8IXH1

Related

ENSP00000484196.2, ENST00000613537.5

Conserved Domains (3) summary

cd00183
Location:37 → 76

TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

TIGR01385
Location:37 → 127

TFSII; transcription elongation factor S-II

pfam06881
Location:566 → 664

Elongin_A; RNA polymerase II transcription factor SIII (Elongin) subunit A