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EcR ecdysone receptor [ Bombyx mori (domestic silkworm) ]

Gene ID: 692756, updated on 19-Jun-2024

Summary

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Gene symbol
EcR
Gene description
ecdysone receptor
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bombyx mori
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; Bombycidae; Bombycinae; Bombyx
Orthologs
fruit fly all
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Genomic context

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See EcR in Genome Data Viewer
Location:
chromosome: 10
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_01 current ASM3026992v2 (GCF_030269925.1) 10 NC_085116.1 (6071595..6344745)
103 previous assembly Bmori_2016v1.0 (GCF_014905235.1) 10 NC_051367.1 (5898025..6171223)

Chromosome 10 - NC_085116.1Genomic Context describing neighboring genes Neighboring gene telomere-associated protein RIF1 Neighboring gene patched domain-containing protein Neighboring gene microRNA mir-2748 Neighboring gene uncharacterized LOC105842224 Neighboring gene uncharacterized LOC105842223 Neighboring gene uncharacterized LOC134199492 Neighboring gene uncharacterized LOC105842225 Neighboring gene putative fatty acyl-CoA reductase CG5065 Neighboring gene C-type lectin 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Morphological changes and patterns of ecdysone receptor B1 immunolocalization in the anterior silk gland undergoing programmed cell death in the silkworm, Bombyx mori. Goncu E, et al. Acta Histochem, 2009. PMID 18554690
  2. Characterization of core promoter elements for ecdysone receptor isoforms of the silkworm, Bombyx mori. Shirai H, et al. Insect Mol Biol, 2007 Apr. PMID 17298552
  3. EcR expression in the prothoracicotropic hormone-producing neurosecretory cells of the Bombyx mori brain. Hossain M, et al. FEBS J, 2006 Aug. PMID 16911531
  4. Tissue-specific and stage-specific expression of two silkworm ecdysone receptor isoforms -- ecdysteroid-dependent transcription in cultured anterior silk glands. Kamimura M, et al. Eur J Biochem, 1997 Sep 15. PMID 9342230
  5. The silkmoth homolog of the Drosophila ecdysone receptor (B1 isoform): cloning and analysis of expression during follicular cell differentiation. Swevers L, et al. Insect Biochem Mol Biol, 1995 Jul. PMID 7633470

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. tyrosine phosphorylated coincidental with high protein tyrosine phosphorylations during growth to differentiation transition
    Title: Ecdysone receptor and ultraspiracle proteins are tyrosine phosphorylated during adult development of silkmoths.
  2. results indicate that EcR-B1 expression may be important for the process of programmed cell death in the anterior silk glands
    Title: Morphological changes and patterns of ecdysone receptor B1 immunolocalization in the anterior silk gland undergoing programmed cell death in the silkworm, Bombyx mori.
  3. downstream promoter element of BmEcR-B1 is not important for BmEcR-A transcription
    Title: Characterization of core promoter elements for ecdysone receptor isoforms of the silkworm, Bombyx mori.
  4. Analysis of EcR-A and EcR-B1 expression during larval-pupal development showed that both genes were up-regulated by 20-hydroxyecdysone in the B. mori brain.
    Title: EcR expression in the prothoracicotropic hormone-producing neurosecretory cells of the Bombyx mori brain.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ecdysone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ecdysone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ecdysone receptor
Names
20-hydroxy-ecdysone receptor
20E receptor
ecRH
ecdysteroid receptor
nuclear receptor subfamily 1 group H member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001043866.2 → NP_001037331.2  ecdysone receptor isoform B2

    See identical proteins and their annotated locations for NP_001037331.2

    Status: PROVISIONAL

    Source sequence(s)
    L35266
    UniProtKB/TrEMBL
    A7UBN8
    Conserved Domains (2) summary
    cd06938
    Location:353 → 584
    NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
    cd07161
    Location:204 → 294
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers

  2. NM_001173375.1 → NP_001166846.1  ecdysone receptor isoform B1

    See identical proteins and their annotated locations for NP_001166846.1

    Status: PROVISIONAL

    Source sequence(s)
    L35266
    UniProtKB/Swiss-Prot
    P49881
    UniProtKB/TrEMBL
    A7UBN8
    Conserved Domains (2) summary
    cd06938
    Location:353 → 587
    NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
    cd07161
    Location:204 → 294
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers

  3. NM_001173377.1 → NP_001166848.1  ecdysone receptor isoform A

    Status: PROVISIONAL

    Source sequence(s)
    D49476, D49477
    UniProtKB/TrEMBL
    A0A8R1TG29, A8ASF7
    Conserved Domains (2) summary
    cd07161
    Location:122 → 212
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers
    cl11397
    Location:271 → 301
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: GCF_030269925.1-RS_2024_01

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM3026992v2 Primary Assembly

Genomic

  1. NC_085116.1 Reference ASM3026992v2 Primary Assembly

    Range
    6071595..6344745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021350704.3 → XP_021206379.1  ecdysone receptor isoform X1

    UniProtKB/TrEMBL
    A0A8R2HNJ9
    Conserved Domains (2) summary
    cd06938
    Location:271 → 505
    NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
    cd07161
    Location:122 → 212
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers

  2. XM_021350703.3 → XP_021206378.1  ecdysone receptor isoform X1

    UniProtKB/TrEMBL
    A0A8R2HNJ9
    Conserved Domains (2) summary
    cd06938
    Location:271 → 505
    NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
    cd07161
    Location:122 → 212
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers

  3. XM_021350705.3 → XP_021206380.1  ecdysone receptor isoform X2

    UniProtKB/TrEMBL
    A0A8R2HQC1
    Conserved Domains (2) summary
    cd06938
    Location:262 → 496
    NR_LBD_EcR; The ligand binding domain (LBD) of the Ecdysone receptor, a member of the nuclear receptors super family
    cd07161
    Location:113 → 203
    NR_DBD_EcR; DNA-binding domain of Ecdysone receptor (ECR) family is composed of two C4-type zinc fingers

  4. XM_062670319.1 → XP_062526303.1  ecdysone receptor isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49881.1 GenPept UniProtKB/Swiss-Prot:P49881

Gene LinkOut

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