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PTTH prothoracicotropic hormone [ Bombyx mori (domestic silkworm) ]

Gene ID: 692767, updated on 9-Feb-2024

Summary

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Gene symbol
PTTH
Gene description
prothoracicotropic hormone
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bombyx mori
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; Bombycidae; Bombycinae; Bombyx
Also known as
PTTH-KS
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Genomic context

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See PTTH in Genome Data Viewer
Location:
chromosome: 22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_01 current ASM3026992v2 (GCF_030269925.1) 22 NC_085128.1 (9678909..9681254)
103 previous assembly Bmori_2016v1.0 (GCF_014905235.1) 22 NC_051379.1 (9699571..9701916)

Chromosome 22 - NC_085128.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119630255 Neighboring gene zinc finger protein 729 Neighboring gene zinc finger protein 431 Neighboring gene rapamycin-insensitive companion of Tor Neighboring gene uncharacterized LOC134200988

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori. Gu SH, et al. Insect Biochem Mol Biol, 2012 Apr. PMID 22227406
  2. Prothoracicotropic hormone induces tyrosine phosphorylation in prothoracic glands of the silkworm, Bombyx mori. Lin JL, et al. Arch Insect Biochem Physiol, 2011 Mar. PMID 20568296
  3. Transcriptional regulation of the gene for prothoracicotropic hormone in the silkworm, Bombyx mori. Wei ZJ, et al. Mol Biol Rep, 2011 Feb. PMID 20563654
  4. Assignment of disulfide bond location in prothoracicotropic hormone of the silkworm, Bombyx mori: a homodimeric peptide. Ishibashi J, et al. Biochemistry, 1994 May 17. PMID 8180220
  5. Structure and expression of the gene for the prothoracicotropic hormone of the silkmoth Bombyx mori. Adachi-Yamada T, et al. Eur J Biochem, 1994 Mar 1. PMID 8125124

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HR38 is a prothoracicotropic hormone(PTTH)-stimulated immediate early gene that is, at least in part, induced through Ca(2+)/ERK and PI3K signaling. The present study proposes a potential cross talk mechanism between PTTH and ecdysone signaling to regulate insect development and lays a foundation for a better understanding of the mechanisms of PTTH's actions.
    Title: Stimulation of orphan nuclear receptor HR38 gene expression by PTTH in prothoracic glands of the silkworm, Bombyx mori.
  2. There are interconnections among Ca(2+) signaling, adenosine 5'-monophosphate-activated protein kinase, and 4E-BP phosphorylation in in prothoracicotropic hormone (PTTH-activated prothoracic glands of Bombyx mori.
    Title: Signaling involved in PTTH-stimulated 4E-BP phosphorylation in prothoracic gland cells of Bombyx mori.
  3. Study reports the physical basis of neurohormone PTTH sensing by the receptor tyrosine kinase Torso. Hormone binding by Torso is asymmetric and anticooperative, allowing receptor levels to determine the nature of signal transduction.
    Title: Structural Basis of Neurohormone Perception by the Receptor Tyrosine Kinase Torso.
  4. To examine the expression of Rab proteins and neuropeptide hormones in the brain of the silkworm, Bombyx mori.The Rab1 co-localized with prothoracicotropic hormone.
    Title: Relationship between the expression of Rab family GTPases and neuropeptide hormones in the brain of Bombyx mori.
  5. PTTH/PI3K/TOR/4E-BP (S6K) signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands.
    Title: TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori.
  6. The cell-specific expression of two neuropeptide hormone genes, prothoracicotropic hormone (PTTH) and diapause hormone-pheromone biosynthesis activating neuropeptide gene (DH-PBAN), is activated by the Pitx transcription factor.
    Title: Identification of a cis-regulatory element that directs prothoracicotropic hormone gene expression in the silkworm Bombyx mori.
  7. The authors showed that Bombyx mori prothoracicotropic hormone (PTTH)-stimulated ecdysteroidogenesis was partially blocked by LY294002 and wortmannin, indicating that phosphoinositide 3-kinase (PI3K) is involved in PTTH-stimulated ecdysteroidogenesis.
    Title: Involvement of PI3K/Akt signaling in PTTH-stimulated ecdysteroidogenesis by prothoracic glands of the silkworm, Bombyx mori.
  8. Study showed that prothoracicotropic hormone (PTTH) stimulates a rapid increase in tyrosine phosphorylation of at least 2 proteins in prothoracic glands: extracellular signal-regulated kinase and a 120-kDa protein.
    Title: Prothoracicotropic hormone induces tyrosine phosphorylation in prothoracic glands of the silkworm, Bombyx mori.
  9. the TATA box is involved in regulation of PTTH gene expression in B. mori
    Title: Transcriptional regulation of the gene for prothoracicotropic hormone in the silkworm, Bombyx mori.
  10. PTTH-stimulated ERK phosphorylation is only partially Ca(2+)- and calmodulin-dependent, and HNMPA-(AM)(3)-sensitive receptor tyrosine kinase is involved in activation of ERK phosphorylation by PTTH.
    Title: PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca(2+)/calmodulin and receptor tyrosine kinase.
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General gene information

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Homology

General protein information

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Preferred Names
prothoracicotropic hormone
Names
prothoracicotropic hormone Kinshu Showa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001043884.1 → NP_001037349.1  prothoracicotropic hormone preproprotein

    See identical proteins and their annotated locations for NP_001037349.1

    Status: VALIDATED

    Source sequence(s)
    D90082
    UniProtKB/Swiss-Prot
    P17219
    UniProtKB/TrEMBL
    Q17238

RefSeqs of Annotated Genomes: GCF_030269925.1-RS_2024_01

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM3026992v2 Primary Assembly

Genomic

  1. NC_085128.1 Reference ASM3026992v2 Primary Assembly

    Range
    9678909..9681254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17219.1 GenPept UniProtKB/Swiss-Prot:P17219

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