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Efcab9 EF-hand calcium binding domain 9 [ Mus musculus (house mouse) ]

Gene ID: 69306, updated on 2-Nov-2024

Summary

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Official Symbol
Efcab9provided by MGI
Official Full Name
EF-hand calcium binding domain 9provided by MGI
Primary source
MGI:MGI:1916556
See related
Ensembl:ENSMUSG00000044056 AllianceGenome:MGI:1916556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700007I06Rik; 4930403C08Rik
Summary
Enables calcium ion binding activity and calcium ion sensor activity. Involved in flagellated sperm motility and sperm capacitation. Located in cytoplasm and sperm principal piece. Part of CatSper complex. Orthologous to human EFCAB9 (EF-hand calcium binding domain 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 38.3) and spleen adult (RPKM 1.8) See more
Orthologs
human all
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Genomic context

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See Efcab9 in Genome Data Viewer
Location:
11 A4; 11 18.97 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32472733..32483144, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32522733..32533240, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51948 Neighboring gene ubiquitin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11474 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:32442680-32442833 Neighboring gene serine/threonine kinase 10 Neighboring gene STARR-positive B cell enhancer ABC_E5214 Neighboring gene F-box and WD-40 domain protein 11 Neighboring gene STARR-seq mESC enhancer starr_29115

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella. Yang F, et al. Development, 2022 Jan 15. PMID 34919125, Free PMC Article
  2. 3D structure and in situ arrangements of CatSper channel in the sperm flagellum. Zhao Y, et al. Nat Commun, 2022 Jun 17. PMID 35715406, Free PMC Article
  3. C2cd6-encoded CatSperτ targets sperm calcium channel to Ca(2+) signaling domains in the flagellar membrane. Hwang JY, et al. Cell Rep, 2022 Jan 18. PMID 34998468, Free PMC Article
  4. Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility. Hwang JY, et al. Cell, 2019 May 30. PMID 31056283, Free PMC Article
  5. Structure of a mammalian sperm cation channel complex. Lin S, et al. Nature, 2021 Jul. PMID 34225353

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Clone Names

  • MGC107247

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion sensor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm capacitation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of CatSper complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of CatSper complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
EF-hand calcium-binding domain-containing protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027031.3 → NP_081307.2  EF-hand calcium-binding domain-containing protein 9

    See identical proteins and their annotated locations for NP_081307.2

    Status: VALIDATED

    Source sequence(s)
    AV260313, BC087911
    Consensus CDS
    CCDS24528.1
    UniProtKB/Swiss-Prot
    Q9D5P6, Q9DAM2
    Related
    ENSMUSP00000060205.3, ENSMUST00000054327.3
    Conserved Domains (2) summary
    COG5126
    Location:33 → 162
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam13499
    Location:108 → 162
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    32472733..32483144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243747.4 → XP_011242049.1  EF-hand calcium-binding domain-containing protein 9 isoform X1

    See identical proteins and their annotated locations for XP_011242049.1

    UniProtKB/Swiss-Prot
    Q9D5P6, Q9DAM2
    Conserved Domains (2) summary
    COG5126
    Location:33 → 162
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    pfam13499
    Location:108 → 162
    EF-hand_7; EF-hand domain pair

  2. XM_036156961.1 → XP_036012854.1  EF-hand calcium-binding domain-containing protein 9 isoform X2

    Conserved Domains (1) summary
    pfam13499
    Location:43 → 97
    EF-hand_7; EF-hand domain pair
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAM2.2 GenPept UniProtKB/Swiss-Prot:Q9DAM2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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