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Necab1 N-terminal EF-hand calcium binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 69352, updated on 2-Nov-2024

Summary

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Official Symbol
Necab1provided by MGI
Official Full Name
N-terminal EF-hand calcium binding protein 1provided by MGI
Primary source
MGI:MGI:1916602
See related
Ensembl:ENSMUSG00000040536 AllianceGenome:MGI:1916602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Efcbp1; STIP-1; 1700003H21Rik
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within blastocyst hatching. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in early conceptus. Orthologous to human NECAB1 (N-terminal EF-hand calcium binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 9.2), cortex adult (RPKM 9.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Necab1 in Genome Data Viewer
Location:
4 A2; 4 6.45 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (14952245..15149804, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (14952245..15149804, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6153 Neighboring gene OTU domain containing 6B Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 Neighboring gene predicted gene 11837 Neighboring gene STARR-seq mESC enhancer starr_09640 Neighboring gene STARR-seq mESC enhancer starr_09641 Neighboring gene predicted gene 11844 Neighboring gene predicted gene, 36801 Neighboring gene STARR-seq mESC enhancer starr_09642 Neighboring gene STARR-seq mESC enhancer starr_09643 Neighboring gene STARR-seq mESC enhancer starr_09646 Neighboring gene STARR-seq mESC enhancer starr_09648 Neighboring gene STARR-positive B cell enhancer ABC_E6154 Neighboring gene predicted gene, 51436 Neighboring gene transmembrane protein 64 Neighboring gene STARR-seq mESC enhancer starr_09650 Neighboring gene predicted gene, 29883 Neighboring gene predicted gene, 29829

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cholinergic modulation of Up-Down states in the mouse medial entorhinal cortex in vitro. Hay YA, et al. Eur J Neurosci, 2021 Mar. PMID 33131134
  2. Expression of the calcium binding proteins Necab-1,-2 and -3 in the adult mouse hippocampus and dentate gyrus. Zimmermann B, et al. Brain Res, 2013 Aug 28. PMID 23850650
  3. Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic β-cells. Udagawa H, et al. Sci Rep, 2023 Oct 20. PMID 37863964, Free PMC Article
  4. Thalamus mediates neocortical Down state transition via GABA(B)-receptor-targeting interneurons. Hay YA, et al. Neuron, 2021 Sep 1. PMID 34314698
  5. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. Sugita S, et al. Neuroscience, 2002. PMID 12044471

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic beta-cells.
    Title: Glucocorticoid receptor-NECAB1 axis can negatively regulate insulin secretion in pancreatic β-cells.
  2. The genes for the three Necab's, including Necab-1, were expressed in specific, non-overlapping areas of the hippocampus.
    Title: Expression of the calcium binding proteins Necab-1,-2 and -3 in the adult mouse hippocampus and dentate gyrus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of amyloid precursor protein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-terminal EF-hand calcium-binding protein 1
Names
EF-hand calcium-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178617.4 → NP_848732.3  N-terminal EF-hand calcium-binding protein 1

    See identical proteins and their annotated locations for NP_848732.3

    Status: VALIDATED

    Source sequence(s)
    BC067055
    Consensus CDS
    CCDS17982.1
    UniProtKB/Swiss-Prot
    Q80W91, Q8BG18
    Related
    ENSMUSP00000038165.8, ENSMUST00000041606.14
    Conserved Domains (3) summary
    pfam03992
    Location:254 → 325
    ABM; Antibiotic biosynthesis monooxygenase
    pfam13499
    Location:33 → 89
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:31 → 87
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    14952245..15149804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538234.1 → XP_006538297.1  N-terminal EF-hand calcium-binding protein 1 isoform X1

    Conserved Domains (4) summary
    cd00051
    Location:55 → 111
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd15898
    Location:57 → 83
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:57 → 168
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    pfam03992
    Location:278 → 347
    ABM; Antibiotic biosynthesis monooxygenase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG18.1 GenPept UniProtKB/Swiss-Prot:Q8BG18

Gene LinkOut

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