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Slc38a4 solute carrier family 38, member 4 [ Mus musculus (house mouse) ]

Gene ID: 69354, updated on 2-Nov-2024

Summary

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Official Symbol
Slc38a4provided by MGI
Official Full Name
solute carrier family 38, member 4provided by MGI
Primary source
MGI:MGI:1916604
See related
Ensembl:ENSMUSG00000022464 AllianceGenome:MGI:1916604
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ata3; SNAT4; mATA3; mNAT3; 1110012E16Rik; 1700012A18Rik
Summary
Enables L-arginine transmembrane transporter activity and neutral L-amino acid:sodium symporter activity. Involved in L-alanine import across plasma membrane and L-arginine transmembrane transport. Predicted to be located in microvillus membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; gut; and liver. Orthologous to human SLC38A4 (solute carrier family 38 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 139.1), placenta adult (RPKM 78.5) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Slc38a4 in Genome Data Viewer
Location:
15 F1; 15 52.77 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (96892701..96953837, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (96994816..97055956, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39603 Neighboring gene predicted gene, 32677 Neighboring gene ribosomal protein L10A, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E5511 Neighboring gene STARR-seq mESC enhancer starr_39604 Neighboring gene STARR-seq mESC enhancer starr_39606 Neighboring gene STARR-seq mESC enhancer starr_39607 Neighboring gene STARR-seq mESC enhancer starr_39610 Neighboring gene predicted gene, 32840 Neighboring gene STARR-seq mESC enhancer starr_39612 Neighboring gene predicted gene, 32789 Neighboring gene predicted gene, 32733

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of Slc38a4 imprinting is a major cause of mouse placenta hyperplasia in somatic cell nuclear transferred embryos at late gestation. Xie Z, et al. Cell Rep, 2022 Feb 22. PMID 35196486, Free PMC Article
  2. Mouse system-N amino acid transporter, mNAT3, expressed in hepatocytes and regulated by insulin-activated and phosphoinositide 3-kinase-dependent signalling. Gu S, et al. Biochem J, 2003 May 1. PMID 12537539, Free PMC Article
  3. Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter. Padmanabhan Iyer R, et al. PLoS One, 2013. PMID 23451088, Free PMC Article
  4. Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein. Shi Q, et al. J Biol Chem, 2011 Nov 4. PMID 21917917, Free PMC Article
  5. ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer. Kim HS, et al. Exp Mol Med, 2023 Jan. PMID 36599932, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer.
    Title: ADAR1-dependent miR-3144-3p editing simultaneously induces MSI2 expression and suppresses SLC38A4 expression in liver cancer.
  2. Slc38a4/SNAT4 mutant mice could be a promising model for the analysis of placental defects.
    Title: Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice.
  3. results suggest that cysteine residues 249 and 321 form a disulfide bridge, which plays an important role in substrate transport but has no effect on trafficking of SNAT4 to the cell surface.
    Title: Identification of a disulfide bridge important for transport function of SNAT4 neutral amino acid transporter.
  4. Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein
    Title: Membrane topological structure of neutral system N/A amino acid transporter 4 (SNAT4) protein.
  5. Ata3 has been identified as an imprinted gene by high-throughput screening using RIKEN cDNA microarray.
    Title: Asb4, Ata3, and Dcn are novel imprinted genes identified by high-throughput screening using RIKEN cDNA microarray.
  6. crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4, Slc38a2, and Slc2a3) may be a component of the genetic control of nutrient supply and demand during mammalian development
    Title: Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6)  1 citation
  • Gene trapped (2) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-arginine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alanine:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables alanine:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neutral L-amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid:sodium symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in L-alanine import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-alanine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-alanine import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in L-alanine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-arginine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium-coupled neutral amino acid transporter 4
Names
Na(+)-coupled neutral amino acid transporter 4
amino acid transporter A3
system A amino acid transporter 3
system-N amino acid transporter 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358058.1 → NP_001344987.1  sodium-coupled neutral amino acid transporter 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC113177, AC158560
    Consensus CDS
    CCDS27779.1
    UniProtKB/Swiss-Prot
    Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
    Related
    ENSMUSP00000154818.2, ENSMUST00000230086.2
    Conserved Domains (1) summary
    cl00456
    Location:75 → 535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. NM_001358059.1 → NP_001344988.1  sodium-coupled neutral amino acid transporter 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC113177, AC158560
    Consensus CDS
    CCDS27779.1
    UniProtKB/Swiss-Prot
    Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
    Related
    ENSMUSP00000127676.2, ENSMUST00000166223.2
    Conserved Domains (1) summary
    cl00456
    Location:75 → 535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. NM_001358060.1 → NP_001344989.1  sodium-coupled neutral amino acid transporter 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC113177, AC158560
    Consensus CDS
    CCDS27779.1
    UniProtKB/Swiss-Prot
    Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
    Related
    ENSMUSP00000155158.2, ENSMUST00000231039.2
    Conserved Domains (1) summary
    cl00456
    Location:75 → 535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  4. NM_027052.3 → NP_081328.2  sodium-coupled neutral amino acid transporter 4

    See identical proteins and their annotated locations for NP_081328.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK051023
    Consensus CDS
    CCDS27779.1
    UniProtKB/Swiss-Prot
    Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
    Related
    ENSMUSP00000023101.4, ENSMUST00000023101.10
    Conserved Domains (1) summary
    cl00456
    Location:75 → 535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    96892701..96953837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521350.5 → XP_006521413.1  sodium-coupled neutral amino acid transporter 4 isoform X1

    See identical proteins and their annotated locations for XP_006521413.1

    UniProtKB/Swiss-Prot
    Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
    Conserved Domains (1) summary
    cl00456
    Location:75 → 535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_006521351.4 → XP_006521414.1  sodium-coupled neutral amino acid transporter 4 isoform X1

    See identical proteins and their annotated locations for XP_006521414.1

    UniProtKB/Swiss-Prot
    Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
    Conserved Domains (1) summary
    cl00456
    Location:75 → 535
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1S9.1 GenPept UniProtKB/Swiss-Prot:Q8R1S9

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