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Lyzl6 lysozyme-like 6 [ Mus musculus (house mouse) ]

Gene ID: 69444, updated on 4-May-2024

Summary

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Official Symbol
Lyzl6provided by MGI
Official Full Name
lysozyme-like 6provided by MGI
Primary source
MGI:MGI:1916694
See related
Ensembl:ENSMUSG00000020945 AllianceGenome:MGI:1916694
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lyc1; Lyzb; 1700023H08Rik
Summary
Predicted to enable lysozyme activity. Predicted to be involved in defense response to bacterium and fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to act upstream of or within cytolysis and single fertilization. Located in sperm midpiece. Orthologous to human LYZL6 (lysozyme like 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 87.6) See more
Orthologs
human all
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Genomic context

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See Lyzl6 in Genome Data Viewer
Location:
11 E1; 11 67.4 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103521894..103529716, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103631068..103638890, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30850 Neighboring gene leucine rich repeat containing 37A Neighboring gene STARR-seq mESC enhancer starr_30851 Neighboring gene STARR-seq mESC enhancer starr_30852 Neighboring gene leucine rich repeat containing 37 Neighboring gene STARR-seq mESC enhancer starr_30853 Neighboring gene STARR-seq mESC enhancer starr_30854 Neighboring gene STARR-seq mESC enhancer starr_30855 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene RIKEN cDNA 1700072I22 gene Neighboring gene reprimo-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterisation of Lyzls in mice and antibacterial properties of human LYZL6. Wei J, et al. Asian J Androl, 2013 Nov. PMID 24013621, Free PMC Article
  2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables lysozyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
involved_in fertilization ISO
Inferred from Sequence Orthology
more info
  
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fusion of sperm to egg plasma membrane involved in single fertilization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lysozyme-like protein 6
Names
lysozyme b
lysozyme-like protein 1
NP_001343401.1
NP_081359.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356472.2 → NP_001343401.1  lysozyme-like protein 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AK006279, AV254473, BY092087
    Consensus CDS
    CCDS25519.1
    UniProtKB/Swiss-Prot
    Q9DA11
    UniProtKB/TrEMBL
    A0A077S2U3
    Related
    ENSMUSP00000102628.2, ENSMUST00000107014.8
    Conserved Domains (1) summary
    cd00119
    Location:21 → 142
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

  2. NM_027083.3 → NP_081359.1  lysozyme-like protein 6 precursor

    See identical proteins and their annotated locations for NP_081359.1

    Status: VALIDATED

    Source sequence(s)
    AV254473, BC048617, BY092087
    Consensus CDS
    CCDS25519.1
    UniProtKB/Swiss-Prot
    Q9DA11
    UniProtKB/TrEMBL
    A0A077S2U3
    Related
    ENSMUSP00000021328.8, ENSMUST00000021328.8
    Conserved Domains (1) summary
    cd00119
    Location:21 → 142
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    103521894..103529716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DA11.1 GenPept UniProtKB/Swiss-Prot:Q9DA11

Gene LinkOut

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