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Cdk13 cyclin dependent kinase 13 [ Mus musculus (house mouse) ]

Gene ID: 69562, updated on 28-Oct-2024

Summary

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Official Symbol
Cdk13provided by MGI
Official Full Name
cyclin dependent kinase 13provided by MGI
Primary source
MGI:MGI:1916812
See related
Ensembl:ENSMUSG00000041297 AllianceGenome:MGI:1916812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cdc2l5; 2310015O17Rik
Summary
Enables cyclin binding activity and protein kinase binding activity. Involved in alternative mRNA splicing, via spliceosome. Acts upstream of or within negative regulation of stem cell differentiation. Part of nuclear cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including future brain; genitourinary system; heart; primitive streak; and unsegmented mesenchyme. Used to study congenital heart defects, dysmorphic facial features, and intellectual developmental disorder. Human ortholog(s) of this gene implicated in congenital heart defects, dysmorphic facial features, and intellectual developmental disorder; hepatocellular carcinoma; intellectual disability; and prostate carcinoma. Orthologous to human CDK13 (cyclin dependent kinase 13). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 9.0), thymus adult (RPKM 8.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cdk13 in Genome Data Viewer
Location:
13 A2; 13 6.05 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (17885309..17979960, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (17711676..17805212, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene succinyl-CoA glutarate-CoA transferase Neighboring gene STARR-positive B cell enhancer ABC_E1869 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:17787115-17787302 Neighboring gene STARR-seq mESC enhancer starr_33763 Neighboring gene predicted gene, 40826 Neighboring gene M-phase specific PLK1 intereacting protein Neighboring gene STARR-positive B cell enhancer ABC_E10780 Neighboring gene STARR-seq mESC enhancer starr_33764 Neighboring gene microRNA 466i Neighboring gene predicted gene, 24018 Neighboring gene predicted gene, 18859

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer. Cheng L, et al. Cancer Res, 2022 Oct 4. PMID 35857807
  2. Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. Chen HR, et al. Exp Neurol, 2014 Nov. PMID 24999027
  3. CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing. Chen HH, et al. Biochem Biophys Res Commun, 2007 Mar 16. PMID 17261272
  4. Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13. Nováková M, et al. Front Cell Dev Biol, 2019. PMID 31440507, Free PMC Article
  5. Early embryogenesis in CHDFIDD mouse model reveals facial clefts and altered cranial neurogenesis. Hampl M, et al. Dis Model Mech, 2024 Jun 1. PMID 38511331, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.
    Title: Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.
  2. The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.
    Title: Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II CTD heptapeptide repeat kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
involved_in hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin K-CDK13 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin/CDK positive transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 13
Names
CDC2-related protein kinase 5
cell division cycle 2-like 5 (cholinesterase-related cell division controller)
cell division cycle 2-like protein kinase 5
cell division protein kinase 13
NP_001074527.1
NP_081394.1
XP_006516829.1
XP_006516830.1
XP_011242646.1
XP_017171082.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081058.2 → NP_001074527.1  cyclin-dependent kinase 13 isoform 1

    See identical proteins and their annotated locations for NP_001074527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC154219, AC154828
    Consensus CDS
    CCDS36604.1
    UniProtKB/Swiss-Prot
    E9QKZ6, Q69ZA1, Q80V11, Q8BZG1, Q8K0A4
    Related
    ENSMUSP00000036013.8, ENSMUST00000042365.9
    Conserved Domains (2) summary
    smart00220
    Location:705 → 994
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:697 → 998
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  2. NM_027118.1 → NP_081394.1  cyclin-dependent kinase 13 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AC154219, AC154828
    Consensus CDS
    CCDS88417.1
    UniProtKB/Swiss-Prot
    Q69ZA1
    Related
    ENSMUSP00000152820.2, ENSMUST00000223490.2
    Conserved Domains (2) summary
    smart00220
    Location:705 → 994
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07864
    Location:697 → 998
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    17885309..17979960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516767.5 → XP_006516830.1  cyclin-dependent kinase 13 isoform X2

    Conserved Domains (1) summary
    cd07864
    Location:697 → 998
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  2. XM_006516766.5 → XP_006516829.1  cyclin-dependent kinase 13 isoform X1

    Conserved Domains (1) summary
    cd07864
    Location:697 → 998
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  3. XM_011244344.4 → XP_011242646.1  cyclin-dependent kinase 13 isoform X4

    UniProtKB/TrEMBL
    A0A1Y7VLM0
    Related
    ENSMUSP00000152539.2, ENSMUST00000222800.2
    Conserved Domains (1) summary
    cd07864
    Location:83 → 384
    STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

  4. XM_017315593.3 → XP_017171082.1  cyclin-dependent kinase 13 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:697 → 929
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZA1.3 GenPept UniProtKB/Swiss-Prot:Q69ZA1

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