Hilpda hypoxia inducible lipid droplet associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hilpdaprovided by MGI
Official Full Name: hypoxia inducible lipid droplet associatedprovided by MGI
Primary source: MGI:MGI:1916823
See related: Ensembl:ENSMUSG00000043421 AllianceGenome:MGI:1916823
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hig2; 2310016C08Rik
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in several processes, including autocrine signaling; positive regulation of cytokine production; and positive regulation of lipid storage. Predicted to be located in several cellular components, including cell surface; nucleoplasm; and secretory granule. Predicted to be active in lipid droplet. Human ortholog(s) of this gene implicated in colorectal cancer and hepatocellular carcinoma. Orthologous to human HILPDA (hypoxia inducible lipid droplet associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 46.4), liver E18 (RPKM 18.6) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 12.36 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (29272487..29275448)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (29272488..29275449)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia.
Title: HILPDA promotes NASH-driven HCC development by restraining intracellular fatty acid flux in hypoxia.
Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis.
Title: Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis.
Lipid droplet storage promotes murine pancreatic tumor growth.
Title: Lipid droplet storage promotes murine pancreatic tumor growth.
Authors conclude that Hig2 localizes to LDs in adipocytes, promoting adipose tissue lipid deposition and that its selective deficiency in active brown/beige adipose tissue mediates improved glucose tolerance at 23 degrees C.
Title: Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance.
Thus, macrophage Hilpda is crucial to foam-cell formation and lipid deposition, and to controlled prostaglandin-E2 production. By these means Hilpda promotes lesion formation and progression of atherosclerosis
Title: Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice.
HILPDA is highly abundant in adipose tissue, where its levels are induced by peroxisome proliferator-activated receptor gamma and beta-adrenergic stimulation. In contrast to the reported inhibition of lipolysis by HILPDA in hepatocytes, those data do not support an important direct role of HILPDA in the regulation of lipolysis in adipocytes in vivo and in vitro.
Title: Hypoxia-Inducible Lipid Droplet-Associated Is Not a Direct Physiological Regulator of Lipolysis in Adipose Tissue.
When fasted, HILPDA KO mice are unable to maintain body temperature and become hypothermic at 22 degrees C.
Title: Stress-responsive HILPDA is necessary for thermoregulation during fasting.
data uncover HILPDA as a novel PPAR target that raises hepatic triglyceride storage via regulation of triglyceride secretion.
Title: Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion.
HIG2 was up-regulated by hypoxia and HIF inducers in all cell types and mouse organs investigated and abundantly expressed in renal clear-cell carcinomas
Title: Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in autocrine signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in autocrine signaling	ISO Inferred from Sequence Orthology more info
involved_in autocrine signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid storage	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: hypoxia-inducible lipid droplet-associated protein

Names: hypoxia-inducible gene 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190461.1 → NP_001177390.1 hypoxia-inducible lipid droplet-associated protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).

Source sequence(s)

AC079277

Conserved Domains (1) summary

pfam15220
Location:32 → 94

HILPDA; Hypoxia-inducible lipid droplet-associated
NM_023516.5 → NP_076005.1 hypoxia-inducible lipid droplet-associated protein isoform 2

See identical proteins and their annotated locations for NP_076005.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' exon and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK009377, AW538932, BY113188

Consensus CDS

CCDS39450.1

UniProtKB/Swiss-Prot

Q3UMU3, Q8VDY1, Q9JLS0

Related

ENSMUSP00000060791.9, ENSMUST00000054445.9

Conserved Domains (1) summary

pfam15220
Location:1 → 63

HILPDA; Hypoxia-inducible lipid droplet-associated