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Fastkd3 FAST kinase domains 3 [ Mus musculus (house mouse) ]

Gene ID: 69577, updated on 2-Nov-2024

Summary

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Official Symbol
Fastkd3provided by MGI
Official Full Name
FAST kinase domains 3provided by MGI
Primary source
MGI:MGI:1916827
See related
Ensembl:ENSMUSG00000021532 AllianceGenome:MGI:1916827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310010B21Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mitochondrial RNA processing; mitochondrial cytochrome c oxidase assembly; and post-transcriptional regulation of gene expression. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Orthologous to human FASTKD3 (FAST kinase domains 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 5.9), CNS E11.5 (RPKM 5.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fastkd3 in Genome Data Viewer
Location:
13 B3; 13 35.55 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (68730281..68740457)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (68582167..68592338)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46386 Neighboring gene STARR-seq mESC enhancer starr_34921 Neighboring gene VISTA enhancer mm1330 Neighboring gene STARR-seq mESC enhancer starr_34924 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Neighboring gene predicted gene, 34903 Neighboring gene STARR-seq mESC enhancer starr_34926 Neighboring gene cilia and flagella associated protein 90 Neighboring gene adenylate cyclase 2 Neighboring gene STARR-seq mESC enhancer starr_34927 Neighboring gene STARR-seq mESC enhancer starr_34928 Neighboring gene farnesyl diphosphate synthetase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitochondrial translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitochondrial mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitochondrial mRNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitochondrial mRNA stability ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FAST kinase domain-containing protein 3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330423.1 → NP_001317352.1  FAST kinase domain-containing protein 3, mitochondrial

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK033189, CA560457, CJ265660, CT033781
    Consensus CDS
    CCDS36719.1
    UniProtKB/Swiss-Prot
    Q5XKD3, Q6P9N4, Q8BSN9, Q8CB52, Q8CCG7

  2. NM_027123.5 → NP_081399.3  FAST kinase domain-containing protein 3, mitochondrial

    See identical proteins and their annotated locations for NP_081399.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK033189, CJ265660, CT033781
    Consensus CDS
    CCDS36719.1
    UniProtKB/Swiss-Prot
    Q5XKD3, Q6P9N4, Q8BSN9, Q8CB52, Q8CCG7
    Related
    ENSMUSP00000061737.9, ENSMUST00000051784.10
    Conserved Domains (3) summary
    smart00952
    Location:594 → 651
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:410 → 478
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:494 → 580
    FAST_2; FAST kinase-like protein, subdomain 2

RNA

  1. NR_138477.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK032530, AK033189, CJ265660, CT033781
    Related
    ENSMUST00000223319.2

  2. NR_138478.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon and uses alternate splice sites in the second exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
    Source sequence(s)
    AK033189, AW988524, CJ265660, CT033781
    Related
    ENSMUST00000222068.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    68730281..68740457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315595.2 → XP_017171084.1  FAST kinase domain-containing protein 3, mitochondrial isoform X3

    Conserved Domains (2) summary
    smart00952
    Location:381 → 438
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam08368
    Location:281 → 367
    FAST_2; FAST kinase-like protein, subdomain 2

  2. XM_006517364.4 → XP_006517427.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

    Conserved Domains (3) summary
    smart00952
    Location:631 → 688
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:447 → 515
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:531 → 617
    FAST_2; FAST kinase-like protein, subdomain 2

  3. XM_006517366.4 → XP_006517429.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006517429.1

    Conserved Domains (3) summary
    smart00952
    Location:397 → 454
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:213 → 281
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:297 → 383
    FAST_2; FAST kinase-like protein, subdomain 2

  4. XM_006517367.1 → XP_006517430.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006517430.1

    Conserved Domains (3) summary
    smart00952
    Location:397 → 454
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:213 → 281
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:297 → 383
    FAST_2; FAST kinase-like protein, subdomain 2

RNA

  1. XR_004938066.1 RNA Sequence

  2. XR_382449.4 RNA Sequence

  3. XR_003950475.1 RNA Sequence

  4. XR_004938067.1 RNA Sequence

  5. XR_003950476.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BSN9.2 GenPept UniProtKB/Swiss-Prot:Q8BSN9

Gene LinkOut

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