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Plekhm2 pleckstrin homology domain containing, family M (with RUN domain) member 2 [ Mus musculus (house mouse) ]

Gene ID: 69582, updated on 2-Nov-2024

Summary

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Official Symbol
Plekhm2provided by MGI
Official Full Name
pleckstrin homology domain containing, family M (with RUN domain) member 2provided by MGI
Primary source
MGI:MGI:1916832
See related
Ensembl:ENSMUSG00000028917 AllianceGenome:MGI:1916832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0842; 2310034J19Rik
Summary
Predicted to enable kinesin binding activity. Predicted to be involved in several processes, including autophagosome-lysosome fusion; late endosome to lysosome transport; and natural killer cell mediated cytotoxicity. Predicted to be located in autolysosome and lysosomal membrane. Predicted to be active in endosome membrane. Orthologous to human PLEKHM2 (pleckstrin homology and RUN domain containing M2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 27.1), heart adult (RPKM 26.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Plekhm2 in Genome Data Viewer
Location:
4 D3; 4 74.64 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141353043..141391457, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141625732..141664146, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AI507597 Neighboring gene transmembrane protein 82 Neighboring gene STARR-positive B cell enhancer mm9_chr4:141180986-141181286 Neighboring gene solute carrier family 25, member 34 Neighboring gene predicted gene, 54266 Neighboring gene STARR-seq mESC enhancer starr_11927 Neighboring gene regulatory solute carrier protein, family 1, member 1 Neighboring gene DNA-damage inducible protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E11263 Neighboring gene predicted gene, 34863 Neighboring gene STARR-seq mESC enhancer starr_11931

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Salmonella effector protein SifA plays a dual role in virulence. Zhao W, et al. Sci Rep, 2015 Aug 13. PMID 26268777, Free PMC Article
  2. Plekhm2 acts as an autophagy modulator in murine heart and cardiofibroblasts. Etzion S, et al. Sci Rep, 2024 Jun 28. PMID 38942823, Free PMC Article
  3. Interaction between the SifA virulence factor and its host target SKIP is essential for Salmonella pathogenesis. Diacovich L, et al. J Biol Chem, 2009 Nov 27. PMID 19801640, Free PMC Article
  4. TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells. Saitoh SI, et al. Nat Commun, 2017 Nov 17. PMID 29150602, Free PMC Article
  5. Lysosomal dynamics regulate mammalian cortical neurogenesis. Zou W, et al. Dev Cell, 2024 Jan 8. PMID 38103552

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plekhm2 acts as an autophagy modulator in murine heart and cardiofibroblasts.
    Title: Plekhm2 acts as an autophagy modulator in murine heart and cardiofibroblasts.
  2. We used a model of SKIP knockout mice to show that this protein mediates the host susceptibility to salmonellosis and to establish that SifA also contributes to Salmonella virulence independently of its interaction with SKIP
    Title: The Salmonella effector protein SifA plays a dual role in virulence.
  3. Data shoe that the N-terminal domain of SifA is sufficient to interact with the pleckstrin homology domain of SKIP, forming a 1:1 complex with a micromolar dissociation constant.
    Title: Interaction between the SifA virulence factor and its host target SKIP is essential for Salmonella pathogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome-lysosome fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in late endosome to lysosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lysosome localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lysosome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome localization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in natural killer cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in autolysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family M member 2
Names
PH domain-containing family M member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033150.2 → NP_001028322.1  pleckstrin homology domain-containing family M member 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL670446
    Consensus CDS
    CCDS51348.1
    UniProtKB/Swiss-Prot
    A2ADE1, Q3U0Q7, Q6PD22, Q80TQ5
    UniProtKB/TrEMBL
    Z4YJW6
    Related
    ENSMUSP00000081221.5, ENSMUST00000084203.11
    Conserved Domains (3) summary
    smart00593
    Location:93 → 156
    RUN; domain involved in Ras-like GTPase signaling
    cd13309
    Location:787 → 889
    PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain
    pfam00169
    Location:786 → 887
    PH; PH domain

  2. NM_001347237.2 → NP_001334166.1  pleckstrin homology domain-containing family M member 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL670446
    Consensus CDS
    CCDS84816.1
    UniProtKB/Swiss-Prot
    A2ADE1, Q3U0Q7, Q6PD22, Q80TQ5
    UniProtKB/TrEMBL
    A2ADE0
    Related
    ENSMUSP00000030751.5, ENSMUST00000030751.5
    Conserved Domains (2) summary
    smart00593
    Location:93 → 156
    RUN; domain involved in Ras-like GTPase signaling
    cd13309
    Location:767 → 869
    PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    141353043..141391457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164404.1 → XP_036020297.1  pleckstrin homology domain-containing family M member 2 isoform X1

    UniProtKB/Swiss-Prot
    A2ADE1, Q3U0Q7, Q6PD22, Q80TQ5
    Conserved Domains (1) summary
    cd13309
    Location:602 → 704
    PH_SKIP; SifA and kinesin-interacting protein Pleckstrin homology (PH) domain

RNA

  1. XR_390780.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TQ5.2 GenPept UniProtKB/Swiss-Prot:Q80TQ5

Gene LinkOut

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