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ptxA pertussis toxin ADP-ribosyltransferase subunit S1 [ Bordetella pertussis ]

Gene ID: 69599992, updated on 1-Aug-2024

Summary

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Gene symbol
ptxA
Gene description
pertussis toxin ADP-ribosyltransferase subunit S1
Locus tag
CXD86_RS00450
Gene type
protein coding
Organism
Bordetella pertussis (strain: H640, nat-host: Homo sapiens)
Lineage
Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella
Old locus tag
CXD86_00450
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Genomic context

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NZ_CP025371.1Genomic Context describing neighboring genes Neighboring gene pertussis toxin binding subunit S5 Neighboring gene pertussis toxin binding subunit S4 Neighboring gene pertussis toxin binding subunit S2 Neighboring gene tripartite tricarboxylate transporter substrate binding protein Neighboring gene hypothetical protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NZ_CP025371.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structures of pertussis toxin with NAD(+) and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity. Sakari M, et al. J Biol Chem, 2022 May. PMID 35378130, Free PMC Article
  2. Bordetella parapertussis and Bordetella bronchiseptica contain transcriptionally silent pertussis toxin genes. Aricò B, et al. J Bacteriol, 1987 Jun. PMID 3584073, Free PMC Article
  3. Identification of a region in the S1 subunit of pertussis toxin that is required for enzymatic activity and that contributes to the formation of a neutralizing antigenic determinant. Cieplak W, et al. Proc Natl Acad Sci U S A, 1988 Jul. PMID 2455296, Free PMC Article
  4. Pertussis toxin gene: nucleotide sequence and genetic organization. Locht C, et al. Science, 1986 Jun 6. PMID 3704651

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structures of pertussis toxin with NAD(+) and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity.
    Title: Crystal structures of pertussis toxin with NAD(+) and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity.
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General protein information

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Preferred Names
pertussis toxin ADP-ribosyltransferase subunit S1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NZ_CP025371.1 Reference assembly

    Range
    84308..85117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_019248461.1 pertussis toxin ADP-ribosyltransferase subunit S1 [Bordetella pertussis]

    See identical proteins and their annotated locations for WP_019248461.1

    UniProtKB/TrEMBL
    A0AAI9J4M2, C0MPK6, J7FNA7, W8QKK9
    Conserved Domains (1) summary
    pfam02917
    Location:36 → 268
    Pertussis_S1; Pertussis toxin, subunit 1
Nucleotide Protein
Heading Accession and Version