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Dapk1 death associated protein kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 69635, updated on 2-Nov-2024

Summary

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Official Symbol
Dapk1provided by MGI
Official Full Name
death associated protein kinase 1provided by MGI
Primary source
MGI:MGI:1916885
See related
Ensembl:ENSMUSG00000021559 AllianceGenome:MGI:1916885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D13Ucla1; DAP-Kinase
Summary
Enables ATP binding activity; calmodulin binding activity; and protein kinase activity. Involved in several processes, including cellular response to type II interferon; protein phosphorylation; and regulation of NMDA receptor activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytoplasm. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in urinary bladder cancer and uterine fibroid. Orthologous to human DAPK1 (death associated protein kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 29.9), lung adult (RPKM 28.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Dapk1 in Genome Data Viewer
Location:
13 B2; 13 32.53 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (60749506..60911005)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (60601723..60763191)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34735 Neighboring gene predicted gene, 35333 Neighboring gene RIKEN cDNA A530001N23 gene Neighboring gene STARR-seq mESC enhancer starr_34736 Neighboring gene STARR-seq mESC enhancer starr_34737 Neighboring gene STARR-seq mESC enhancer starr_34738 Neighboring gene STARR-seq mESC enhancer starr_34740 Neighboring gene predicted gene, 35540 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:60839367-60839520 Neighboring gene STARR-seq mESC enhancer starr_34741 Neighboring gene cDNA sequence BC051665 Neighboring gene cathepsin L-like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protection of blood-brain barrier by endothelial DAPK1 deletion after stroke. Gu Z, et al. Biochem Biophys Res Commun, 2024 Sep 10. PMID 38851140
  2. Deletion of the kinase domain from death-associated protein kinase attenuates p53 expression in chronic obstructive uropathy. Yukawa K, et al. Int J Mol Med, 2005 Sep. PMID 16077944
  3. Deletion of the kinase domain from death-associated protein kinase enhances spatial memory in mice. Yukawa K, et al. Int J Mol Med, 2006 May. PMID 16596273
  4. dapk1, encoding an activator of a p19ARF-p53-mediated apoptotic checkpoint, is a transcription target of p53. Martoriati A, et al. Oncogene, 2005 Feb 17. PMID 15608685
  5. DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death. Gozuacik D, et al. Cell Death Differ, 2008 Dec. PMID 18806755

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protection of blood-brain barrier by endothelial DAPK1 deletion after stroke.
    Title: Protection of blood-brain barrier by endothelial DAPK1 deletion after stroke.
  2. Quantitative Proteomic and Phosphoproteomic Analyses Reveal a Role of Death-Associated Protein Kinase 1 in Regulating Hippocampal Synapse.
    Title: Quantitative Proteomic and Phosphoproteomic Analyses Reveal a Role of Death-Associated Protein Kinase 1 in Regulating Hippocampal Synapse.
  3. Ablation of Death-Associated Protein Kinase 1 Changes the Transcriptomic Profile and Alters Neural-Related Pathways in the Brain.
    Title: Ablation of Death-Associated Protein Kinase 1 Changes the Transcriptomic Profile and Alters Neural-Related Pathways in the Brain.
  4. DAPK1 Interacts with the p38 Isoform MAPK14, Preventing Its Nuclear Translocation and Stimulation of Bone Marrow Adipogenesis.
    Title: DAPK1 Interacts with the p38 Isoform MAPK14, Preventing Its Nuclear Translocation and Stimulation of Bone Marrow Adipogenesis.
  5. MicroRNA-26b-5p Targets DAPK1 to Reduce Intestinal Ischemia/Reperfusion Injury via Inhibition of Intestinal Mucosal Cell Apoptosis.
    Title: MicroRNA-26b-5p Targets DAPK1 to Reduce Intestinal Ischemia/Reperfusion Injury via Inhibition of Intestinal Mucosal Cell Apoptosis.
  6. Death-associated protein kinase 1 mediates Abeta42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease.
    Title: Death-associated protein kinase 1 mediates Aβ42 aggregation-induced neuronal apoptosis and tau dysregulation in Alzheimer's disease.
  7. Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice.
    Title: Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice.
  8. Young DAPK1 knockout mice have altered presynaptic function.
    Title: Young DAPK1 knockout mice have altered presynaptic function.
  9. DAPK1 (death associated protein kinase 1) mediates mTORC1 activation and antiviral activities in CD8(+) T cells.
    Title: DAPK1 (death associated protein kinase 1) mediates mTORC1 activation and antiviral activities in CD8(+) T cells.
  10. Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease.
    Title: Melatonin directly binds and inhibits death-associated protein kinase 1 function in Alzheimer's disease.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (8)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 2310039H24Rik, 2810425C21Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin-1 binding IEA
Inferred from Electronic Annotation
more info
  
enables syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in cellular response to hydroperoxide IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hydroperoxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to type II interferon IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to tumor cell IEA
Inferred from Electronic Annotation
more info
  
involved_in defense response to tumor cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagic cell death ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of NMDA receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of response to tumor cell ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DAPK1-calmodulin complex ISO
Inferred from Sequence Orthology
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
death-associated protein kinase 1
Names
DAP kinase 1
NP_001272846.1
NP_083929.2
NP_598823.1
XP_006517433.1
XP_017171087.1
XP_030103260.1
XP_036014050.1
XP_036014051.1
XP_036014052.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285917.1 → NP_001272846.1  death-associated protein kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001272846.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154176, AK145922, BC060161, BQ745486, CT010498, CX244175
    Consensus CDS
    CCDS88466.1
    UniProtKB/Swiss-Prot
    Q80YE6, Q80YE7, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7
    UniProtKB/TrEMBL
    Q3UKP8
    Related
    ENSMUSP00000153607.2, ENSMUST00000226059.2
    Conserved Domains (5) summary
    PHA03095
    Location:425 → 667
    PHA03095; ankyrin-like protein; Provisional
    cd08782
    Location:1308 → 1393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:379 → 431
    Ank_4; Ankyrin repeats (many copies)

  2. NM_029653.3 → NP_083929.2  death-associated protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_083929.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC154176, AK145922, BC060161, BQ745486, CT010498, CX244175
    Consensus CDS
    CCDS26581.1
    UniProtKB/TrEMBL
    Q3UKP8
    Related
    ENSMUSP00000076666.6, ENSMUST00000077453.13
    Conserved Domains (6) summary
    PHA03095
    Location:425 → 667
    PHA03095; ankyrin-like protein; Provisional
    cd08782
    Location:1308 → 1393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:379 → 431
    Ank_4; Ankyrin repeats (many copies)
    cl39094
    Location:338 → 409
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_134062.2 → NP_598823.1  death-associated protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_598823.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK145922, BC060161, BQ745486, CT010498
    Consensus CDS
    CCDS26581.1
    UniProtKB/TrEMBL
    Q3UKP8
    Related
    ENSMUSP00000040825.8, ENSMUST00000044083.9
    Conserved Domains (6) summary
    PHA03095
    Location:425 → 667
    PHA03095; ankyrin-like protein; Provisional
    cd08782
    Location:1308 → 1393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:379 → 431
    Ank_4; Ankyrin repeats (many copies)
    cl39094
    Location:338 → 409
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    60749506..60911005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247400.2 → XP_030103260.1  death-associated protein kinase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q80YE6, Q80YE7, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7
    UniProtKB/TrEMBL
    Q3UKP8
    Conserved Domains (5) summary
    PHA03095
    Location:425 → 667
    PHA03095; ankyrin-like protein; Provisional
    cd08782
    Location:1308 → 1393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:379 → 431
    Ank_4; Ankyrin repeats (many copies)

  2. XM_036158159.1 → XP_036014052.1  death-associated protein kinase 1 isoform X5

    UniProtKB/TrEMBL
    Q3UKP8
    Conserved Domains (6) summary
    PHA03095
    Location:425 → 667
    PHA03095; ankyrin-like protein; Provisional
    cd08782
    Location:1308 → 1393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:379 → 431
    Ank_4; Ankyrin repeats (many copies)
    cl39094
    Location:338 → 409
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_006517370.5 → XP_006517433.1  death-associated protein kinase 1 isoform X4

    See identical proteins and their annotated locations for XP_006517433.1

    UniProtKB/Swiss-Prot
    Q80YE6, Q80YE7, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7
    UniProtKB/TrEMBL
    Q3UKP8
    Conserved Domains (5) summary
    PHA03095
    Location:425 → 667
    PHA03095; ankyrin-like protein; Provisional
    cd08782
    Location:1308 → 1393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7 → 275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
    sd00045
    Location:412 → 442
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:379 → 431
    Ank_4; Ankyrin repeats (many copies)

  4. XM_017315598.3 → XP_017171087.1  death-associated protein kinase 1 isoform X3

    UniProtKB/TrEMBL
    Q3UKP8
    Conserved Domains (5) summary
    PHA03095
    Location:406 → 648
    PHA03095; ankyrin-like protein; Provisional
    cd08782
    Location:1289 → 1374
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    sd00045
    Location:393 → 423
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:360 → 412
    Ank_4; Ankyrin repeats (many copies)
    cl21453
    Location:2 → 256
    PKc_like; Protein Kinases, catalytic domain

  5. XM_036158158.1 → XP_036014051.1  death-associated protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    Q3UKP8
    Conserved Domains (6) summary
    PLN03192
    Location:537 → 790
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd08782
    Location:1330 → 1415
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    sd00045
    Location:434 → 464
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:401 → 453
    Ank_4; Ankyrin repeats (many copies)
    cl21453
    Location:35 → 297
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:450 → 661
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_036158157.1 → XP_036014050.1  death-associated protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    Q3UKP8
    Conserved Domains (6) summary
    PLN03192
    Location:537 → 790
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd08782
    Location:1330 → 1415
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    sd00045
    Location:434 → 464
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:401 → 453
    Ank_4; Ankyrin repeats (many copies)
    cl21453
    Location:35 → 297
    PKc_like; Protein Kinases, catalytic domain
    cl39094
    Location:450 → 661
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YE7.3 GenPept UniProtKB/Swiss-Prot:Q80YE7

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