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Pir pirin [ Mus musculus (house mouse) ]

Gene ID: 69656, updated on 2-Nov-2024

Summary

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Official Symbol
Pirprovided by MGI
Official Full Name
pirinprovided by MGI
Primary source
MGI:MGI:1916906
See related
Ensembl:ENSMUSG00000031379 AllianceGenome:MGI:1916906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pirnl; 2310042L19Rik
Summary
Predicted to enable metal ion binding activity; quercetin 2,3-dioxygenase activity; and transcription coregulator activity. Acts upstream of or within myeloid cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer; choroid plexus; and cortical plate. Orthologous to human PIR (pirin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 6.3), liver E14 (RPKM 3.9) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Pir in Genome Data Viewer
Location:
X F5; X 76.12 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (163052427..163156009)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164269431..164373013)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48236 Neighboring gene angiotensin converting enzyme 2 Neighboring gene BMX non-receptor tyrosine kinase Neighboring gene predicted gene, 19251 Neighboring gene STARR-seq mESC enhancer starr_48237 Neighboring gene predicted gene, 46692 Neighboring gene predicted gene, 57673 Neighboring gene predicted gene, 22023 Neighboring gene STARR-seq mESC enhancer starr_48238 Neighboring gene vascular endothelial growth factor D Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:160844233-160844342 Neighboring gene STARR-seq mESC enhancer starr_48240 Neighboring gene STARR-positive B cell enhancer ABC_E269 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival. Ma H, et al. Adv Sci (Weinh), 2024 Mar. PMID 38148593, Free PMC Article
  2. Putative proto-oncogene Pir expression is significantly up-regulated in the spleen and kidney of cytosolic superoxide dismutase-deficient mice. Brzóska K, et al. Redox Rep, 2011. PMID 21801495, Free PMC Article
  3. PLIN5 Suppresses Lipotoxicity and Ferroptosis in Cardiomyocyte via Modulating PIR/NF-κB Axis. Shen X, et al. Int Heart J, 2024 May 31. PMID 38749744
  4. Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. Licciulli S, et al. Leukemia, 2010 Feb. PMID 20010624
  5. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Calvo SE, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19372376, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PLIN5 Suppresses Lipotoxicity and Ferroptosis in Cardiomyocyte via Modulating PIR/NF-kappaB Axis.
    Title: PLIN5 Suppresses Lipotoxicity and Ferroptosis in Cardiomyocyte via Modulating PIR/NF-κB Axis.
  2. Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.
    Title: Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.
  3. Sod1(-/-) mice have a significantly elevated level of Pir mRNA in the spleen and kidney but not in the liver, heart, or/and brain.
    Title: Putative proto-oncogene Pir expression is significantly up-regulated in the spleen and kidney of cytosolic superoxide dismutase-deficient mice.
  4. Includes the study of an upstream ORF in this gene, and shows that it functions to reduce protein levels by ~38%.
    Title: Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables quercetin 2,3-dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables quercetin 2,3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables quercetin 2,3-dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in monocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
pirin
Names
iron-binding nuclear protein
pirin like
probable quercetin 2,3-dioxygenase PIR
probable quercetinase
NP_001288331.1
NP_081429.1
XP_036017982.1
XP_036017983.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301402.1 → NP_001288331.1  pirin isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in translation initiation at a downstream in-frame start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL671706, AL732475
    Conserved Domains (3) summary
    COG1741
    Location:1 → 203
    YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
    pfam05726
    Location:99 → 205
    Pirin_C; Pirin C-terminal cupin domain
    cl21464
    Location:1 → 46
    cupin_like; Conserved domain found in cupin and related proteins

  2. NM_027153.3 → NP_081429.1  pirin isoform 1

    See identical proteins and their annotated locations for NP_081429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK009757, AL732475, BY718294
    Consensus CDS
    CCDS30520.1
    UniProtKB/Swiss-Prot
    A2AIH9, Q3UAN0, Q8CIE9, Q9D711
    UniProtKB/TrEMBL
    A2AIH8
    Related
    ENSMUSP00000033749.8, ENSMUST00000033749.9
    Conserved Domains (1) summary
    COG1741
    Location:17 → 275
    YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    163052427..163156009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162089.1 → XP_036017982.1  pirin isoform X1

    UniProtKB/Swiss-Prot
    A2AIH9, Q3UAN0, Q8CIE9, Q9D711
    UniProtKB/TrEMBL
    A2AIH8
    Related
    ENSMUSP00000118045.2, ENSMUST00000145412.8
    Conserved Domains (1) summary
    COG1741
    Location:17 → 275
    YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]

  2. XM_036162090.1 → XP_036017983.1  pirin isoform X2

    UniProtKB/TrEMBL
    A2AIH8
    Conserved Domains (1) summary
    COG1741
    Location:17 → 260
    YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D711.1 GenPept UniProtKB/Swiss-Prot:Q9D711

Gene LinkOut

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