Ipmk inositol polyphosphate multikinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ipmkprovided by MGI
Official Full Name: inositol polyphosphate multikinaseprovided by MGI
Primary source: MGI:MGI:1916968
See related: Ensembl:ENSMUSG00000060733 AllianceGenome:MGI:1916968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Impk; 2410017C19Rik
Summary: Enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Acts upstream of or within inositol phosphate biosynthetic process and neural tube formation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; hindlimb ridge; nervous system; retina nuclear layer; and trunk somite. Orthologous to human IPMK (inositol polyphosphate multikinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in small intestine adult (RPKM 30.9), colon adult (RPKM 26.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B5.3; 10 36.89 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (71183574..71221715)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (71347744..71385885)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inositol polyphosphate multikinase modulates free fatty acids-induced insulin resistance in primary mouse hepatocytes.
Title: Inositol polyphosphate multikinase modulates free fatty acids-induced insulin resistance in primary mouse hepatocytes.
miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling.
Title: miRNA-Induced Downregulation of IPMK in Macrophages Mediates Lipopolysaccharide-Triggered TLR4 Signaling.
Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis.
Title: Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis.
IPMK modulates hepatic glucose production and insulin signaling.
Title: IPMK modulates hepatic glucose production and insulin signaling.
Phytocannabinoid-dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity.
Title: Phytocannabinoid-dependent mTORC1 regulation is dependent upon inositol polyphosphate multikinase activity.
Inositol polyphosphate multikinase in adipocytes is dispensable for regulating energy metabolism and whole body metabolic homeostasis.
Title: Inositol polyphosphate multikinase in adipocytes is dispensable for regulating energy metabolism and whole body metabolic homeostasis.
Deletion of IPMK in cell lines and intact mice virtually abolishes lipophagy, promotes liver damage as well as inflammation, and impairs hepatocyte regeneration.
Title: IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration.
These results suggest a physiological role for IPMK in regulating expression of Syt2.
Title: Inositol polyphosphate multikinase deficiency leads to aberrant induction of synaptotagmin-2 in the forebrain.
Study utilized B cell-specific inositol polyphosphate multikinase (IPMK)-deficient mice to investigate the role of higher order inositol phosphates (InsP6) in B cell immunity and showed that IPMK is a regulator of T cell-independent immune responses and that InsP6 confers a mechanism to regulate the activity of Bruton's tyrosine kinase (Btk) in B cell receptor signaling.
Title: Inositol polyphosphates promote T cell-independent humoral immunity via the regulation of Bruton's tyrosine kinase.
IP5 promotes HIF-1alpha prolyl hydroxylation and pVHL-dependent degradation of HIF-1alpha. IPMK deletion in mouse brain increases HIF-1alpha/VEGF levels and vascularization. This disrupts blood-brain barrier and enhances brain blood vessel permeability. IPMK, via its product IP5, negatively regulates angiogenesis by inhibiting VEGF expression. IP5 acts by enhancing HIF-1alpha hydroxylation and thus pVHL-dependent degra...
Title: Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (4) 1 citation

General gene information

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Markers

BB252113 (e-PCR)
- UniSTS:208556

RH125777 (e-PCR)
- UniSTS:162524

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables flavonoid binding	ISO Inferred from Sequence Orthology more info
enables inositol tetrakisphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,2,3,4,6-pentakisphosphate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,3,4,6-tetrakisphosphate 5-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,4,5,6-tetrakisphosphate 3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol-1,4,5-trisphosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,4,5-trisphosphate 3-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol-1,4,5-trisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,4,5-trisphosphate 6-kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,4,5-trisphosphate 6-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inositol phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inositol trisphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neural tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inositol polyphosphate multikinase

Names: inositol 1,3,4,6-tetrakisphosphate 5-kinase

NP_001334120.1

EC 2.7.1.140

EC 2.7.1.151

EC 2.7.1.153

NP_081460.1

EC 2.7.1.140

EC 2.7.1.151

EC 2.7.1.153

XP_011241857.1

EC 2.7.1.140

EC 2.7.1.151

EC 2.7.1.153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347191.2 → NP_001334120.1 inositol polyphosphate multikinase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa longer than isoform 1.

Source sequence(s)

AC156270

Consensus CDS

CCDS83711.1

UniProtKB/TrEMBL

D3YWA2

Related

ENSMUSP00000112568.2, ENSMUST00000121446.2
NM_027184.3 → NP_081460.1 inositol polyphosphate multikinase isoform 1

See identical proteins and their annotated locations for NP_081460.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the shorter isoform (1).

Source sequence(s)

AC156270

Consensus CDS

CCDS23918.1

UniProtKB/Swiss-Prot

Q7TT16, Q8BZ11, Q8BZA8, Q9CWM9

Related

ENSMUSP00000078240.7, ENSMUST00000079252.13

Conserved Domains (1) summary

pfam03770
Location:110 → 391

IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

71183574..71221715

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243555.2 → XP_011241857.1 inositol polyphosphate multikinase isoform X1

Conserved Domains (1) summary

cl12283
Location:111 → 194

IPK; Inositol polyphosphate kinase