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Usp46 ubiquitin specific peptidase 46 [ Mus musculus (house mouse) ]

Gene ID: 69727, updated on 2-Nov-2024

Summary

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Official Symbol
Usp46provided by MGI
Official Full Name
ubiquitin specific peptidase 46provided by MGI
Primary source
MGI:MGI:1916977
See related
Ensembl:ENSMUSG00000054814 AllianceGenome:MGI:1916977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1190009E20Rik; 2410018I08Rik
Summary
Enables deubiquitinase activity. Involved in regulation of GABAergic synaptic transmission. Acts upstream of or within several processes, including adult feeding behavior; behavioral fear response; and behavioral response to ethanol. Predicted to be located in cytoplasm. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Is expressed in cerebral cortex intermediate zone; cortical plate; and pancreas epithelium. Orthologous to human USP46 (ubiquitin specific peptidase 46). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 10.7), cerebellum adult (RPKM 9.1) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Usp46 in Genome Data Viewer
Location:
5 C3.3; 5 39.33 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (74159387..74229070, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (73998726..74068411, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700019F05 gene Neighboring gene STARR-seq mESC enhancer starr_13394 Neighboring gene STARR-seq mESC enhancer starr_13395 Neighboring gene expressed sequence C78283 Neighboring gene ubiquitin specific peptidase 46, opposite strand 1 Neighboring gene predicted gene, 52817 Neighboring gene STARR-positive B cell enhancer ABC_E8062 Neighboring gene small nucleolar RNA, H/ACA box 26 Neighboring gene differentiation antagonizing non-protein coding RNA Neighboring gene predicted gene, 32002

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impaired Maternal Behavior in Usp46 Mutant Mice: A Model for Trans-Generational Transmission of Maternal Care. Umemura S, et al. PLoS One, 2015. PMID 26284364, Free PMC Article
  2. Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice. Imai S, et al. PLoS One, 2013. PMID 23472206, Free PMC Article
  3. Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system. Imai S, et al. PLoS One, 2012. PMID 22720038, Free PMC Article
  4. Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Tomida S, et al. Nat Genet, 2009 Jun. PMID 19465912
  5. Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity. Zhang W, et al. PLoS One, 2011. PMID 22043315, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Usp46 mutation is associated with Impaired Maternal Behavior.
    Title: Impaired Maternal Behavior in Usp46 Mutant Mice: A Model for Trans-Generational Transmission of Maternal Care.
  2. Usp46 regulates a wide range of behavioral phenotypes that might be related to mental disorders
    Title: Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice.
  3. results suggest that the Lys 92 deletion of USP46 could influence enzyme activity and thereby provide a molecular clue how the enzyme regulating the pathogenesis of mental illnesses.
    Title: Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables deubiquitinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within adult feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within righting reflex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 46
Names
deubiquitinating enzyme 46
ubiquitin specific protease 46
ubiquitin thioesterase 46
ubiquitin thiolesterase 46
ubiquitin-specific-processing protease 46
NP_001404629.1
NP_001404630.1
NP_808229.1
XP_006504332.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417700.1 → NP_001404629.1  ubiquitin carboxyl-terminal hydrolase 46 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164570, AC242530

  2. NM_001417701.1 → NP_001404630.1  ubiquitin carboxyl-terminal hydrolase 46 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC164570, AC242530

  3. NM_177561.4 → NP_808229.1  ubiquitin carboxyl-terminal hydrolase 46 isoform 1

    See identical proteins and their annotated locations for NP_808229.1

    Status: VALIDATED

    Source sequence(s)
    AC164570, AC242530
    Consensus CDS
    CCDS39112.1
    UniProtKB/Swiss-Prot
    P62069, Q3ULU5
    Related
    ENSMUSP00000070554.8, ENSMUST00000068058.14
    Conserved Domains (1) summary
    cd02663
    Location:36 → 363
    Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    74159387..74229070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504269.2 → XP_006504332.1  ubiquitin carboxyl-terminal hydrolase 46 isoform X2

    See identical proteins and their annotated locations for XP_006504332.1

    Conserved Domains (1) summary
    cd02663
    Location:1 → 247
    Peptidase_C19G; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62069.1 GenPept UniProtKB/Swiss-Prot:P62069

Gene LinkOut

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