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Tnfaip8l2 tumor necrosis factor, alpha-induced protein 8-like 2 [ Mus musculus (house mouse) ]

Gene ID: 69769, updated on 29-Oct-2024

Summary

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Official Symbol
Tnfaip8l2provided by MGI
Official Full Name
tumor necrosis factor, alpha-induced protein 8-like 2provided by MGI
Primary source
MGI:MGI:1917019
See related
Ensembl:ENSMUSG00000013707 AllianceGenome:MGI:1917019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIPE2; 1810019A08Rik
Summary
Acts upstream of or within negative regulation of T cell activation and negative regulation of inflammatory response. Located in cytoplasm. Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human TNFAIP8L2 (TNF alpha induced protein 8 like 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in spleen adult (RPKM 43.4), thymus adult (RPKM 22.0) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Tnfaip8l2 in Genome Data Viewer
Location:
3 F2.1; 3 40.74 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95046832..95051581, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95139521..95142416, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94937828-94938011 Neighboring gene sodium channel modifier 1 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 1 Neighboring gene microRNA 8099-1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94945477-94945712 Neighboring gene predicted gene 9169 Neighboring gene STARR-seq mESC enhancer starr_08369 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2. Fayngerts SA, et al. Nat Immunol, 2017 Dec. PMID 29058702, Free PMC Article
  2. Gene delivery of TIPE2 attenuates collagen-induced arthritis by modulating inflammation. Zhou J, et al. Int Immunopharmacol, 2020 Feb. PMID 31863922
  3. Loss of TIPE2 Has Opposing Effects on the Pathogenesis of Autoimmune Diseases. Liu R, et al. Front Immunol, 2019. PMID 31616442, Free PMC Article
  4. Tumor Necrosis Factor-α-Induced Protein 8-like 2 Downregulation Reduces CD4⁺ T Lymphocyte Apoptosis in Mice with Thermal Injury. Huang H, et al. Med Sci Monit, 2019 Oct 8. PMID 31591376, Free PMC Article
  5. TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury. Wu X, et al. Inflamm Res, 2019 Nov. PMID 31486847, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TIPE2 gene transfer ameliorates aging-associated osteoarthritis in a progeria mouse model by reducing inflammation and cellular senescence.
    Title: TIPE2 gene transfer ameliorates aging-associated osteoarthritis in a progeria mouse model by reducing inflammation and cellular senescence.
  2. TIPE2 knockout reduces myocardial cell damage by inhibiting IFN-gamma-mediated ferroptosis.
    Title: TIPE2 knockout reduces myocardial cell damage by inhibiting IFN-γ-mediated ferroptosis.
  3. TIPE2 attenuates neuroinflammation and brain injury through Bcl-2/Bax/cleaved caspase-3 apoptotic pathways after intracerebral hemorrhage in mice.
    Title: TIPE2 attenuates neuroinflammation and brain injury through Bcl-2/Bax/cleaved caspase-3 apoptotic pathways after intracerebral hemorrhage in mice.
  4. Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Ameliorates Cardiac Hypertrophy by Targeting TLR4 in Macrophages.
    Title: Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Ameliorates Cardiac Hypertrophy by Targeting TLR4 in Macrophages.
  5. TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.
    Title: TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.
  6. Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer.
    Title: Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer.
  7. TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.
    Title: TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.
  8. TNF-alpha-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppressing autophagy via the TAK1/JNK pathway in septic mice.
    Title: TNF-α-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppressing autophagy via the TAK1/JNK pathway in septic mice.
  9. TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway.
    Title: TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway.
  10. Tumor Necrosis Factor alpha-Induced Protein 8-Like 2 Alleviates Nonalcoholic Fatty Liver Disease Through Suppressing Transforming Growth Factor Beta-Activated Kinase 1 Activation.
    Title: Tumor Necrosis Factor α-Induced Protein 8-Like 2 Alleviates Nonalcoholic Fatty Liver Disease Through Suppressing Transforming Growth Factor Beta-Activated Kinase 1 Activation.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of T cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tumor necrosis factor alpha-induced protein 8-like protein 2
Names
TNF alpha-induced protein 8-like protein 2
TNFAIP8-like protein 2
tumor necrosis factor, alpha-induced protein 8-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027206.3 → NP_081482.1  tumor necrosis factor alpha-induced protein 8-like protein 2

    See identical proteins and their annotated locations for NP_081482.1

    Status: VALIDATED

    Source sequence(s)
    AC131769
    Consensus CDS
    CCDS17603.1
    UniProtKB/Swiss-Prot
    Q9D8Y7
    Related
    ENSMUSP00000013851.4, ENSMUST00000013851.4
    Conserved Domains (1) summary
    pfam05527
    Location:25 → 177
    DUF758; Domain of unknown function (DUF758)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95046832..95051581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502040.5 → XP_006502103.1  tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006502103.1

    UniProtKB/Swiss-Prot
    Q9D8Y7
    Conserved Domains (1) summary
    pfam05527
    Location:25 → 177
    DUF758; Domain of unknown function (DUF758)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8Y7.1 GenPept UniProtKB/Swiss-Prot:Q9D8Y7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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