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Smap2 small ArfGAP 2 [ Mus musculus (house mouse) ]

Gene ID: 69780, updated on 2-Nov-2024

Summary

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Official Symbol
Smap2provided by MGI
Official Full Name
small ArfGAP 2provided by MGI
Primary source
MGI:MGI:1917030
See related
Ensembl:ENSMUSG00000032870 AllianceGenome:MGI:1917030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Smap1l; 1810031K02Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; ganglia; genitourinary system; spleen; and upper jaw. Orthologous to human SMAP2 (small ArfGAP2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen adult (RPKM 26.9), frontal lobe adult (RPKM 20.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Smap2 in Genome Data Viewer
Location:
4 D2.2; 4 56.7 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120825514..120874497, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120968317..121017289, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10254 Neighboring gene STARR-positive B cell enhancer ABC_E6207 Neighboring gene exonuclease 5 Neighboring gene zinc finger protein 69 Neighboring gene STARR-positive B cell enhancer ABC_E6208 Neighboring gene STARR-positive B cell enhancer ABC_E4659 Neighboring gene microRNA 7015 Neighboring gene STARR-positive B cell enhancer ABC_E6209 Neighboring gene STARR-positive B cell enhancer ABC_E3508 Neighboring gene STARR-positive B cell enhancer ABC_E10255 Neighboring gene STARR-positive B cell enhancer ABC_E6210 Neighboring gene STARR-seq mESC enhancer starr_11259 Neighboring gene collagen, type IX, alpha 2 Neighboring gene zinc metallopeptidase, STE24 Neighboring gene predicted gene, 23540

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis. Funaki T, et al. Mol Biol Cell, 2013 Sep. PMID 23864717, Free PMC Article
  2. Localization of SMAP2 to the TGN and its function in the regulation of TGN protein transport. Funaki T, et al. Cell Struct Funct, 2011. PMID 21368446
  3. Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality. Sumiyoshi M, et al. FEBS Lett, 2015 Sep 14. PMID 26296315
  4. SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network. Natsume W, et al. Mol Biol Cell, 2006 Jun. PMID 16571680, Free PMC Article
  5. Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome. Rorick NK, et al. Am J Med Genet A, 2011 Jun. PMID 21574244, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. either SMAP1 or SMAP2, is required for proper embryogenesis
    Title: Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality.
  2. study reveals a link between SMAP2 and CALM/syntaxin2 in clathrin-coated vesicle formation from the trans-Golgi network and subsequent acrosome formation
    Title: The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis.
  3. the trans-Golgi network (TGN) was verified as an additional site of SMAP2 localization based on its co-localization with various TGN-marker proteins.
    Title: Localization of SMAP2 to the TGN and its function in the regulation of TGN protein transport.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
stromal membrane-associated protein 2
Names
stromal membrane-associated GTPase-activating protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133716.3 → NP_598477.2  stromal membrane-associated protein 2

    See identical proteins and their annotated locations for NP_598477.2

    Status: VALIDATED

    Source sequence(s)
    BC052413, BM944792, BQ175680
    Consensus CDS
    CCDS18598.1
    UniProtKB/Swiss-Prot
    Q3U798, Q7TN29
    Related
    ENSMUSP00000035800.8, ENSMUST00000043200.8
    Conserved Domains (2) summary
    pfam01412
    Location:13 → 126
    ArfGap; Putative GTPase activating protein for Arf
    pfam09606
    Location:276 → 416
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    120825514..120874497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503378.4 → XP_006503441.1  stromal membrane-associated protein 2 isoform X1

    Conserved Domains (2) summary
    pfam09606
    Location:196 → 336
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl28907
    Location:1 → 42
    ArfGap; GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)

  2. XM_006503379.4 → XP_006503442.1  stromal membrane-associated protein 2 isoform X2

    Conserved Domains (1) summary
    pfam09606
    Location:195 → 335
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

  3. XM_006503380.3 → XP_006503443.1  stromal membrane-associated protein 2 isoform X3

    Conserved Domains (1) summary
    cd08859
    Location:16 → 122
    ArfGap_SMAP2; Stromal membrane-associated protein 2; a subfamily of the ArfGAP family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TN29.1 GenPept UniProtKB/Swiss-Prot:Q7TN29

Gene LinkOut

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