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LRRK2 leucine rich repeat kinase 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 697930, updated on 17-Aug-2024

Summary

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Official Symbol
LRRK2provided by VGNC
Official Full Name
leucine rich repeat kinase 2provided by VGNC
Primary source
VGNC:VGNC:81447
See related
Ensembl:ENSMMUG00000015857
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See LRRK2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
52
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 11 NC_041764.1 (39533177..39678644)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 11 NC_027903.1 (37964353..38110230)

Chromosome 11 - NC_041764.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 13 Neighboring gene 60S ribosomal protein L30-like Neighboring gene uncharacterized LOC114670828 Neighboring gene mucin 19, oligomeric Neighboring gene uncharacterized LOC114670829 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lrrk2 localization in the primate basal ganglia and thalamus: a light and electron microscopic analysis in monkeys. Lee H, et al. Exp Neurol, 2010 Aug. PMID 20483355, Free PMC Article
  2. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
leucine-rich repeat serine/threonine-protein kinase 2
XP_015006935.2
XP_015006936.2
XP_015006937.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041764.1 Reference Mmul_10 Primary Assembly

    Range
    39533177..39678644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015151451.2 → XP_015006937.2  leucine-rich repeat serine/threonine-protein kinase 2 isoform X3

    UniProtKB/TrEMBL
    G7N6Q0
    Conserved Domains (5) summary
    cd09914
    Location:1334 → 1507
    RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
    COG4886
    Location:1012 → 1360
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:1013 → 1036
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16095
    Location:1527 → 1740
    COR; C-terminal of Roc, COR, domain
    cl21453
    Location:1884 → 2093
    PKc_like; Protein Kinases, catalytic domain

  2. XM_015151449.2 → XP_015006935.2  leucine-rich repeat serine/threonine-protein kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A5F8A5V3
    Conserved Domains (5) summary
    cd09914
    Location:1334 → 1507
    RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
    COG4886
    Location:1012 → 1360
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd14068
    Location:1884 → 2135
    STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
    sd00033
    Location:1013 → 1036
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16095
    Location:1527 → 1740
    COR; C-terminal of Roc, COR, domain

  3. XM_015151450.2 → XP_015006936.2  leucine-rich repeat serine/threonine-protein kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A5F8A5V3, F7C7Z0
    Related
    ENSMMUP00000020845.4, ENSMMUT00000022280.4
    Conserved Domains (5) summary
    cd09914
    Location:1334 → 1507
    RocCOR; Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family
    COG4886
    Location:1012 → 1360
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd14068
    Location:1884 → 2135
    STKc_LRRK2; Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2
    sd00033
    Location:1013 → 1036
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16095
    Location:1527 → 1740
    COR; C-terminal of Roc, COR, domain
Nucleotide Protein
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