Cox11 cytochrome c oxidase assembly protein 11, copper chaperone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cox11provided by MGI
Official Full Name: cytochrome c oxidase assembly protein 11, copper chaperoneprovided by MGI
Primary source: MGI:MGI:1917052
See related: Ensembl:ENSMUSG00000020544 AllianceGenome:MGI:1917052
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2010004I09Rik
Summary: Predicted to enable copper ion binding activity. Acts upstream of or within negative regulation of glucokinase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 23. Orthologous to human COX11 (cytochrome c oxidase copper chaperone COX11). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 8.3), duodenum adult (RPKM 8.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 55.45 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (90529010..90536803)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (90638184..90645977)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RanBP2 associates in vitro and in vivo and colocalizes with the mitochondrial metallochaperone, Cox11, and the pacemaker of glycolysis, hexokinase type I (HKI) via its leucine-rich domain.
Title: RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126947 (e-PCR)
- UniSTS:208731

Cox11 (e-PCR), detects polymorphism
- UniSTS:527291

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ATP biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular monoatomic cation homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular monoatomic cation homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of glucokinase activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome c oxidase assembly protein COX11, mitochondrial

Names: COX11 homolog, cytochrome c oxidase assembly protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199008.2 → NP_950173.1 cytochrome c oxidase assembly protein COX11, mitochondrial

See identical proteins and their annotated locations for NP_950173.1

Status: PROVISIONAL

Source sequence(s)

AK143937

Consensus CDS

CCDS25243.1

UniProtKB/Swiss-Prot

Q3UNX9, Q6P8I6

Related

ENSMUSP00000020851.9, ENSMUST00000020851.15

Conserved Domains (1) summary

PTZ00128
Location:57 → 264

PTZ00128; cytochrome c oxidase assembly protein-like; Provisional