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Slc39a11 solute carrier family 39 (metal ion transporter), member 11 [ Mus musculus (house mouse) ]

Gene ID: 69806, updated on 2-Nov-2024

Summary

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Official Symbol
Slc39a11provided by MGI
Official Full Name
solute carrier family 39 (metal ion transporter), member 11provided by MGI
Primary source
MGI:MGI:1917056
See related
Ensembl:ENSMUSG00000041654 AllianceGenome:MGI:1917056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZIP-11; 1810074D23Rik
Summary
Enables copper ion transmembrane transporter activity and zinc ion transmembrane transporter activity. Involved in zinc ion import across plasma membrane. Located in Golgi apparatus; nucleus; and plasma membrane. Orthologous to human SLC39A11 (solute carrier family 39 member 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in stomach adult (RPKM 17.8), colon adult (RPKM 17.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Slc39a11 in Genome Data Viewer
Location:
11 E2; 11 78.74 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (113135677..113541050, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (113244851..113650200, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732490B19 gene Neighboring gene predicted gene, 39505 Neighboring gene VISTA enhancer mm1526 Neighboring gene STARR-seq mESC enhancer starr_31081 Neighboring gene predicted gene, 30844 Neighboring gene predicted gene, 51927 Neighboring gene predicted gene, 51926 Neighboring gene predicted gene, 42094 Neighboring gene STARR-seq mESC enhancer starr_31085 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113331428-113331537 Neighboring gene predicted gene, 51928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113427091-113427274 Neighboring gene STARR-seq mESC enhancer starr_31093 Neighboring gene STARR-seq mESC enhancer starr_31094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113473355-113473542 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113473648-113473949 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113475868-113476055 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113478982-113479282 Neighboring gene STARR-positive B cell enhancer ABC_E4012 Neighboring gene somatostatin receptor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113545452-113545561 Neighboring gene STARR-positive B cell enhancer ABC_E4013 Neighboring gene STARR-seq mESC enhancer starr_31100 Neighboring gene STARR-seq mESC enhancer starr_31103 Neighboring gene component of oligomeric golgi complex 1 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene cleavage and polyadenylation specific factor 4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization. Martin AB, et al. J Nutr, 2013 Dec. PMID 24089422, Free PMC Article
  2. Mapping the zinc-transporting system in mammary cells: molecular analysis reveals a phenotype-dependent zinc-transporting network during lactation. Kelleher SL, et al. J Cell Physiol, 2012 Apr. PMID 21702047, Free PMC Article
  3. Characterization of the GufA subfamily member SLC39A11/Zip11 as a zinc transporter. Yu Y, et al. J Nutr Biochem, 2013 Oct. PMID 23643525
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in copper ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc transporter ZIP11
Names
solute carrier family 39 member 11
zrt- and Irt-like protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166503.1 → NP_001159975.1  zinc transporter ZIP11 isoform 1

    See identical proteins and their annotated locations for NP_001159975.1

    Status: VALIDATED

    Source sequence(s)
    AK036999, AK049368, BY299357
    Consensus CDS
    CCDS48975.1
    UniProtKB/Swiss-Prot
    Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
    Related
    ENSMUSP00000102244.4, ENSMUST00000106633.10
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  2. NM_001362937.1 → NP_001349866.1  zinc transporter ZIP11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596104, AL603705, AL604025
    Conserved Domains (1) summary
    COG0428
    Location:80 → 416
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  3. NM_001362938.1 → NP_001349867.1  zinc transporter ZIP11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL596104, AL603705, AL604025
    Consensus CDS
    CCDS88280.1
    Related
    ENSMUSP00000037331.10, ENSMUST00000042657.16
    Conserved Domains (1) summary
    COG0428
    Location:6 → 370
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  4. NM_001362939.1 → NP_001349868.1  zinc transporter ZIP11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596104, AL603705, AL603706, AL604025
    Consensus CDS
    CCDS48975.1
    UniProtKB/Swiss-Prot
    Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  5. NM_001362940.1 → NP_001349869.1  zinc transporter ZIP11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596104, AL603705, AL604025
    Consensus CDS
    CCDS48975.1
    UniProtKB/Swiss-Prot
    Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  6. NM_001362941.1 → NP_001349870.1  zinc transporter ZIP11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL596104, AL603705, AL604025
    Consensus CDS
    CCDS36363.1
    Conserved Domains (1) summary
    COG0428
    Location:6 → 335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  7. NM_001362942.1 → NP_001349871.1  zinc transporter ZIP11 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL596104, AL603705, AL603706, AL604025
    Conserved Domains (1) summary
    COG0428
    Location:6 → 329
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  8. NM_001362943.1 → NP_001349872.1  zinc transporter ZIP11 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL596104, AL603705, AL603706, AL604025
    Conserved Domains (1) summary
    COG0428
    Location:1 → 292
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  9. NM_001362944.1 → NP_001349873.1  zinc transporter ZIP11 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL596104, AL603705, AL604025
    Conserved Domains (1) summary
    COG0428
    Location:6 → 285
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  10. NM_027216.5 → NP_081492.4  zinc transporter ZIP11 isoform 2

    See identical proteins and their annotated locations for NP_081492.4

    Status: VALIDATED

    Source sequence(s)
    AK036999, BY299357
    Consensus CDS
    CCDS36363.1
    UniProtKB/Swiss-Prot
    Q8BWY7
    Related
    ENSMUSP00000071469.4, ENSMUST00000071539.10
    Conserved Domains (1) summary
    COG0428
    Location:6 → 335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    113135677..113541050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246287.2 → XP_030102147.1  zinc transporter ZIP11 isoform X4

    Conserved Domains (1) summary
    COG0428
    Location:6 → 335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  2. XM_030246281.2 → XP_030102141.1  zinc transporter ZIP11 isoform X3

    UniProtKB/Swiss-Prot
    Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  3. XM_011249239.4 → XP_011247541.1  zinc transporter ZIP11 isoform X2

    See identical proteins and their annotated locations for XP_011247541.1

    Conserved Domains (1) summary
    COG0428
    Location:6 → 366
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  4. XM_030246286.2 → XP_030102146.1  zinc transporter ZIP11 isoform X4

    Conserved Domains (1) summary
    COG0428
    Location:6 → 335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  5. XM_011249237.4 → XP_011247539.1  zinc transporter ZIP11 isoform X2

    See identical proteins and their annotated locations for XP_011247539.1

    Conserved Domains (1) summary
    COG0428
    Location:6 → 366
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  6. XM_030246284.2 → XP_030102144.1  zinc transporter ZIP11 isoform X4

    Conserved Domains (1) summary
    COG0428
    Location:6 → 335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  7. XM_030246280.2 → XP_030102140.1  zinc transporter ZIP11 isoform X3

    UniProtKB/Swiss-Prot
    Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  8. XM_011249236.4 → XP_011247538.1  zinc transporter ZIP11 isoform X2

    See identical proteins and their annotated locations for XP_011247538.1

    Conserved Domains (1) summary
    COG0428
    Location:6 → 366
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  9. XM_030246283.2 → XP_030102143.1  zinc transporter ZIP11 isoform X4

    Conserved Domains (1) summary
    COG0428
    Location:6 → 335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  10. XM_011249231.3 → XP_011247533.1  zinc transporter ZIP11 isoform X3

    See identical proteins and their annotated locations for XP_011247533.1

    UniProtKB/Swiss-Prot
    Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  11. XM_011249235.4 → XP_011247537.1  zinc transporter ZIP11 isoform X2

    See identical proteins and their annotated locations for XP_011247537.1

    Conserved Domains (1) summary
    COG0428
    Location:6 → 366
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  12. XM_036156969.1 → XP_036012862.1  zinc transporter ZIP11 isoform X3

    UniProtKB/Swiss-Prot
    Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  13. XM_017314742.3 → XP_017170231.1  zinc transporter ZIP11 isoform X2

    Conserved Domains (1) summary
    COG0428
    Location:6 → 366
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  14. XM_036156968.1 → XP_036012861.1  zinc transporter ZIP11 isoform X3

    UniProtKB/Swiss-Prot
    Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  15. XM_036156967.1 → XP_036012860.1  zinc transporter ZIP11 isoform X3

    UniProtKB/Swiss-Prot
    Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  16. XM_036156966.1 → XP_036012859.1  zinc transporter ZIP11 isoform X2

    Conserved Domains (1) summary
    COG0428
    Location:6 → 366
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  17. XM_030246288.1 → XP_030102148.1  zinc transporter ZIP11 isoform X5

    Conserved Domains (1) summary
    COG0428
    Location:6 → 370
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  18. XM_011249230.1 → XP_011247532.1  zinc transporter ZIP11 isoform X1

    Conserved Domains (1) summary
    COG0428
    Location:6 → 359
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  19. XM_011249233.1 → XP_011247535.1  zinc transporter ZIP11 isoform X2

    See identical proteins and their annotated locations for XP_011247535.1

    Conserved Domains (1) summary
    COG0428
    Location:6 → 366
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  20. XM_011249234.4 → XP_011247536.1  zinc transporter ZIP11 isoform X2

    See identical proteins and their annotated locations for XP_011247536.1

    Conserved Domains (1) summary
    COG0428
    Location:6 → 366
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  21. XM_011249240.4 → XP_011247542.1  zinc transporter ZIP11 isoform X2

    See identical proteins and their annotated locations for XP_011247542.1

    Conserved Domains (1) summary
    COG0428
    Location:6 → 366
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  22. XM_011249238.4 → XP_011247540.1  zinc transporter ZIP11 isoform X2

    See identical proteins and their annotated locations for XP_011247540.1

    Conserved Domains (1) summary
    COG0428
    Location:6 → 366
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  23. XM_030246282.2 → XP_030102142.1  zinc transporter ZIP11 isoform X3

    UniProtKB/Swiss-Prot
    Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  24. XM_030246285.2 → XP_030102145.1  zinc transporter ZIP11 isoform X4

    Conserved Domains (1) summary
    COG0428
    Location:6 → 335
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]

  25. XM_006534130.4 → XP_006534193.1  zinc transporter ZIP11 isoform X3

    See identical proteins and their annotated locations for XP_006534193.1

    UniProtKB/Swiss-Prot
    Q8BWY7, Q8BZ08, Q8K0E0, Q8VE72, Q99KI2, Q9D8J0
    Conserved Domains (1) summary
    COG0428
    Location:6 → 342
    ZupT; Zinc transporter ZupT [Inorganic ion transport and metabolism]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWY7.1 GenPept UniProtKB/Swiss-Prot:Q8BWY7

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