Mzb1 marginal zone B and B1 cell-specific protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mzb1provided by MGI
Official Full Name: marginal zone B and B1 cell-specific protein 1provided by MGI
Primary source: MGI:MGI:1917066
See related: Ensembl:ENSMUSG00000024353 AllianceGenome:MGI:1917066
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PACAP; pERp1; 2010001M09Rik
Summary: Involved in several processes, including integrin activation; positive regulation of immunoglobulin production; and regulation of B cell proliferation. Located in endoplasmic reticulum lumen and extracellular region. Part of endoplasmic reticulum chaperone complex. Is expressed in thymus primordium. Orthologous to human MZB1 (marginal zone B and B1 cell specific protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 34.5), large intestine adult (RPKM 13.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B2; 18 19.19 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (35780318..35782420, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (35647265..35650266, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation.
Title: MZB1-mediated IgA secretion suppresses the development and progression of colorectal cancer triggered by gut inflammation.
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation.
Title: Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation.
MZB1 enables efficient interferon alpha secretion in stimulated plasmacytoid dendritic cells.
Title: MZB1 enables efficient interferon α secretion in stimulated plasmacytoid dendritic cells.
promotes secretion of J-chain-containing dimeric IgA and is critical for suppression of gut inflammation
Title: MZB1 promotes the secretion of J-chain-containing dimeric IgA and is critical for the suppression of gut inflammation.
Mzb1-deficiency mimics, in part, the phenotype of Blimp1 deficiency, including the impaired secretion of IgM and the deregulation of Blimp1 target genes.
Title: Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function.
MZB1 seems to act as a substrate-specific cochaperone of GRP94 that enables proper biosynthesis of microHCs under conditions of ER stress.
Title: MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress.
miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1.
Title: Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1.
In a mouse model of asthma 2010001M09Rik (Mzb1) was unaltered 24 hours after allergen exposure, however, by 72 hours a marked increase in 2010001M09Rik mRNA was detected in lung tissue from disease-susceptible C57BL/6 and BALB/c mice.
Title: Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma.
Mzb1 helps to diversify peripheral B cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation.
Title: Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.
Data suggest that pERp1 is either a unique type of oxidoreductase or a previously unidentified class of molecular chaperone that is dedicated to enhancing the oxidative folding of Ig precursors.
Title: pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Markers

AV064572 (e-PCR)
- UniSTS:166081

D14S779 (e-PCR)
- UniSTS:55747

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in integrin activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of B cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of endoplasmic reticulum chaperone complex	IBA Inferred from Biological aspect of Ancestor more info
part_of endoplasmic reticulum chaperone complex	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: marginal zone B- and B1-cell-specific protein

Names: plasma cell-induced ER protein 1; plasma cell-induced resident ER protein; plasma cell-induced resident endoplasmic reticulum protein; proapoptotic caspase adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.