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Fyttd1 forty-two-three domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 69823, updated on 2-Nov-2024

Summary

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Official Symbol
Fyttd1provided by MGI
Official Full Name
forty-two-three domain containing 1provided by MGI
Primary source
MGI:MGI:1917955
See related
Ensembl:ENSMUSG00000022800 AllianceGenome:MGI:1917955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010005M05Rik; 3830411L18Rik; 3830421F13Rik; 4933423A17Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Is expressed in several structures, including genitourinary system; nasal epithelium; palatal shelf mesenchyme; submandibular gland primordium epithelium; and vibrissa epidermal component. Orthologous to human FYTTD1 (forty-two-three domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in placenta adult (RPKM 15.3), CNS E18 (RPKM 12.6) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Fyttd1 in Genome Data Viewer
Location:
16 23.43 cM; 16 B3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32697762..32729333)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32877581..32908963)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene mucin 4 Neighboring gene STARR-seq mESC enhancer starr_40675 Neighboring gene mucin 20 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32813070-32813253 Neighboring gene STARR-seq mESC enhancer starr_40677 Neighboring gene STARR-seq mESC enhancer starr_40678 Neighboring gene somatomedin B domain containing 1 Neighboring gene RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein Neighboring gene VISTA enhancer mm1352 Neighboring gene STARR-positive B cell enhancer mm9_chr16:32877901-32878201 Neighboring gene STARR-positive B cell enhancer ABC_E9930 Neighboring gene STARR-positive B cell enhancer ABC_E8627 Neighboring gene STARR-positive B cell enhancer ABC_E4167 Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 3 Neighboring gene predicted gene 6611 Neighboring gene nuclear encoded rRNA 5S 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Compromised transcription-mRNA export factor THOC2 causes R-loop accumulation, DNA damage and adverse neurodevelopment. Bhattacharjee R, et al. Nat Commun, 2024 Feb 8. PMID 38331934, Free PMC Article
  2. RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation. Liu HB, et al. Adv Sci (Weinh), 2019 Aug 7. PMID 31406667, Free PMC Article
  3. Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Fanis P, et al. Mol Cell Proteomics, 2012 Nov. PMID 22872859, Free PMC Article
  4. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
  5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
UAP56-interacting factor
Names
forty-two-three domain-containing protein 1
protein 40-2-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159349.1 → NP_001152821.1  UAP56-interacting factor isoform 2

    See identical proteins and their annotated locations for NP_001152821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of a coding exon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC139244, AK139638, BY060615
    Consensus CDS
    CCDS49833.1
    UniProtKB/Swiss-Prot
    Q91Z49
    Related
    ENSMUSP00000131446.2, ENSMUST00000171325.9
    Conserved Domains (1) summary
    pfam07078
    Location:20 → 283
    FYTT; Forty-two-three protein

  2. NM_001356387.1 → NP_001343316.1  UAP56-interacting factor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139244
    Conserved Domains (1) summary
    pfam07078
    Location:20 → 292
    FYTT; Forty-two-three protein

  3. NM_027226.4 → NP_081502.2  UAP56-interacting factor isoform 1

    See identical proteins and their annotated locations for NP_081502.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC139244, AK170511, BY060615
    Consensus CDS
    CCDS28125.1
    UniProtKB/Swiss-Prot
    Q3TJ68, Q3UT89, Q8BVM8, Q8K361, Q91Z49, Q921B0, Q9D6A8
    Related
    ENSMUSP00000023489.5, ENSMUST00000023489.11
    Conserved Domains (1) summary
    pfam07078
    Location:20 → 317
    FYTT; Forty-two-three protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    32697762..32729333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522522.4 → XP_006522585.1  UAP56-interacting factor isoform X1

    See identical proteins and their annotated locations for XP_006522585.1

    Conserved Domains (1) summary
    pfam07078
    Location:1 → 251
    FYTT; Forty-two-three protein

  2. XM_006522523.5 → XP_006522586.1  UAP56-interacting factor isoform X2

    Conserved Domains (1) summary
    pfam07078
    Location:20 → 218
    FYTT; Forty-two-three protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Z49.1 GenPept UniProtKB/Swiss-Prot:Q91Z49

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