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Mrto4 mRNA turnover 4, ribosome maturation factor [ Mus musculus (house mouse) ]

Gene ID: 69902, updated on 2-Nov-2024

Summary

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Official Symbol
Mrto4provided by MGI
Official Full Name
mRNA turnover 4, ribosome maturation factorprovided by MGI
Primary source
MGI:MGI:1917152
See related
Ensembl:ENSMUSG00000028741 AllianceGenome:MGI:1917152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mrt4; Mg684; 2610012O22Rik
Summary
Predicted to be involved in nuclear-transcribed mRNA catabolic process; rRNA processing; and ribosomal large subunit biogenesis. Predicted to be located in cytoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in genitourinary system; liver lobe; pancreas; and submandibular gland primordium. Orthologous to human MRTO4 (MRT4 homolog, ribosome maturation factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 24.0), liver E14 (RPKM 24.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrto4 in Genome Data Viewer
Location:
4 D3; 4 70.65 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139074751..139079887, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139347440..139352576, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 66 member 1 Neighboring gene aldo-keto reductase family 7, member A5 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138886553-138886854 Neighboring gene cyclin D3, pseudogene Neighboring gene ER membrane protein complex subunit 1 Neighboring gene STARR-seq mESC enhancer starr_11828 Neighboring gene STARR-seq mESC enhancer starr_11829 Neighboring gene STARR-seq mESC enhancer starr_11830 Neighboring gene ubiquitin protein ligase E3 component n-recognin 4 Neighboring gene nuclear encoded tRNA valine 1 (anticodon AAC)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis. Mikula M, et al. Proteome Sci, 2015. PMID 26336360, Free PMC Article
  2. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article
  3. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mRNA turnover protein 4 homolog
Names
MRT4, mRNA turnover 4, homolog
mRNA turnover 4, homolog
muscle protein684
ribosome assembly factor Mrto4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290810.1 → NP_001277739.1  mRNA turnover protein 4 homolog isoform 1

    See identical proteins and their annotated locations for NP_001277739.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK011387, BC096556, BY083288, BY246960
    Consensus CDS
    CCDS71505.1
    UniProtKB/Swiss-Prot
    Q99JR7, Q9D0I8
    UniProtKB/TrEMBL
    A2AMU9
    Related
    ENSMUSP00000099561.4, ENSMUST00000102503.10
    Conserved Domains (1) summary
    cd05796
    Location:21 → 183
    Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...

  2. NM_001356476.1 → NP_001343405.1  mRNA turnover protein 4 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK011387, AL807811, BC096556, BY083288, BY246960
    UniProtKB/TrEMBL
    Q9QYY3
    Conserved Domains (1) summary
    cd05796
    Location:1 → 136
    Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...

  3. NM_023536.3 → NP_076025.1  mRNA turnover protein 4 homolog isoform 2

    See identical proteins and their annotated locations for NP_076025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
    Source sequence(s)
    AK011387, BC096556, BY083288, BY246960
    Consensus CDS
    CCDS18845.1
    UniProtKB/TrEMBL
    A2AMV1
    Related
    ENSMUSP00000030513.7, ENSMUST00000030513.13
    Conserved Domains (1) summary
    cd05796
    Location:21 → 183
    Ribosomal_P0_like; Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    139074751..139079887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0I8.1 GenPept UniProtKB/Swiss-Prot:Q9D0I8

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