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DYNLT2 dynein light chain Tctex-type 2 [ Homo sapiens (human) ]

Gene ID: 6991, updated on 2-Nov-2024

Summary

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Official Symbol
DYNLT2provided by HGNC
Official Full Name
dynein light chain Tctex-type 2provided by HGNC
Primary source
HGNC:HGNC:11695
See related
Ensembl:ENSG00000184786 MIM:186977; AllianceGenome:HGNC:11695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCTE3; oda12; TCTEX2; Tctex4; TCTEX1D3
Summary
Predicted to enable dynein intermediate chain binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in cytosol and sperm flagellum. Predicted to be part of cytoplasmic dynein complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 8.5), ovary (RPKM 0.9) and 7 other tissues See more
Orthologs
mouse all
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Genomic context

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See DYNLT2 in Genome Data Viewer
Location:
6q27
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (169725091..169751572, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (171079012..171105502, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (170140205..170151668, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene WD repeat domain 27 Neighboring gene uncharacterized LOC124901471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170040667-170041282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170047131-170048124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25463 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:170056229-170057024 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:170057025-170057820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170061015-170061514 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:170062913-170064112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170068091-170068591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170067590-170068090 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:170067058-170067246 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170092723-170093223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:170124719-170125261 Neighboring gene chromosome 6 open reading frame 120 Neighboring gene MPRA-validated peak6328 silencer Neighboring gene PHD finger protein 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170171824-170172324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170172325-170172825 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:170183046-170183546 Neighboring gene ER membrane associated RNA degradation Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170200599-170201291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170201292-170201985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:170201986-170202678 Neighboring gene long intergenic non-protein coding RNA 242 Neighboring gene long intergenic non-protein coding RNA 574 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:170227060-170227735 Neighboring gene zinc finger protein 227-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. T-complex-associated-testis-expressed 3 (TCTE3) is a novel marker for pancreatobiliary carcinomas. Zhao CL, et al. Hum Pathol, 2017 Dec. PMID 29079176, Free PMC Article
  2. Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array. Teshiba R, et al. Pediatr Surg Int, 2011 Feb. PMID 21085971
  3. Study of Linc00574 Regulatory Effect on the TCTE3 Expression in Sperm Motility. Saberiyan M, et al. Reprod Sci, 2021 Jan. PMID 32749594
  4. Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia. Neesen J, et al. Cytogenet Genome Res, 2002. PMID 12584439
  5. Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. Rappold GA, et al. Genomics, 1992 Aug. PMID 1505969

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study of Linc00574 Regulatory Effect on the TCTE3 Expression in Sperm Motility.
    Title: Study of Linc00574 Regulatory Effect on the TCTE3 Expression in Sperm Motility.
  2. TCTE3 is a useful marker of pancreatobiliary differentiation and may aid in the diagnosis of pancreatobiliary adenocarcinomas.
    Title: T-complex-associated-testis-expressed 3 (TCTE3) is a novel marker for pancreatobiliary carcinomas.
  3. Because TCTE3 encodes a putative light chain of the outer dynein arm of cilia and human diseases caused by ciliary dysfunction show various phenotypes including skeletal defect, TCTE3 may be a genetic candidate influencing CDH.
    Title: Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC142199

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein light chain Tctex-type protein 2
Names
T-complex testis-specific protein 3
T-complex-associated testis-expressed protein 3
Tctex1 domain containing 3
t-complex-associated-testis-expressed 3
tctex1 domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174910.3 → NP_777570.1  dynein light chain Tctex-type protein 2

    See identical proteins and their annotated locations for NP_777570.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AF519569, AL354892, BX089062
    Consensus CDS
    CCDS5310.1
    UniProtKB/Swiss-Prot
    Q8IZS6
    Related
    ENSP00000355736.3, ENST00000366774.4
    Conserved Domains (2) summary
    pfam03645
    Location:100 → 196
    Tctex-1; Tctex-1 family
    cl25363
    Location:11 → 72
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

RNA

  1. NR_138070.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is intronless and differs in the 3' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC043594, BC063455
    Related
    ENST00000628156.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    169725091..169751572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715554.4 → XP_006715617.1  dynein light chain Tctex-type protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006715617.1

    Conserved Domains (1) summary
    pfam03645
    Location:43 → 136
    Tctex-1; Tctex-1 family

  2. XM_011536093.4 → XP_011534395.1  dynein light chain Tctex-type protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011534395.1

    UniProtKB/Swiss-Prot
    Q8IZS6
    Conserved Domains (2) summary
    pfam03645
    Location:100 → 196
    Tctex-1; Tctex-1 family
    cl25363
    Location:11 → 72
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187552.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    292..26774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328683.1 → XP_054184658.1  dynein light chain Tctex-type protein 2 isoform X2

  2. XM_054328682.1 → XP_054184657.1  dynein light chain Tctex-type protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZS6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    171079012..171105502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356278.1 → XP_054212253.1  dynein light chain Tctex-type protein 2 isoform X2

  2. XM_054356277.1 → XP_054212252.1  dynein light chain Tctex-type protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8IZS6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZS6.1 GenPept UniProtKB/Swiss-Prot:Q8IZS6

Gene LinkOut

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