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Nabp2 nucleic acid binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 69917, updated on 2-Nov-2024

Summary

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Official Symbol
Nabp2provided by MGI
Official Full Name
nucleic acid binding protein 2provided by MGI
Primary source
MGI:MGI:1917167
See related
Ensembl:ENSMUSG00000025374 AllianceGenome:MGI:1917167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SSB1; Obfc2b; 2610036N15Rik
Summary
Predicted to enable DNA polymerase binding activity and G-rich strand telomeric DNA binding activity. Involved in DNA repair and positive regulation of telomere capping. Located in chromosome, telomeric region. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NABP2 (nucleic acid binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 13.1), whole brain E14.5 (RPKM 12.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nabp2 in Genome Data Viewer
Location:
10 D3; 10 76.55 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128237263..128247426, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128401394..128411548, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 52 Neighboring gene microRNA 6915 Neighboring gene solute carrier family 39 (metal ion transporter), member 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127846873-127847141 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127848187-127848374 Neighboring gene STARR-positive B cell enhancer ABC_E6940 Neighboring gene ring finger protein 41 Neighboring gene predicted gene, 26347 Neighboring gene nuclear encoded tRNA serine 2 (anticodon CGA)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Yu H, et al. Nat Neurosci, 2015 Jun. PMID 25915473, Free PMC Article
  2. NABP1, a novel RORgamma-regulated gene encoding a single-stranded nucleic-acid-binding protein. Kang HS, et al. Biochem J, 2006 Jul 1. PMID 16533169, Free PMC Article
  3. Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress. Shi W, et al. Blood, 2017 May 4. PMID 28270450, Free PMC Article
  4. SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors. Pfeifer M, et al. J Immunol, 2019 Jun 15. PMID 31085591, Free PMC Article
  5. Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres. Gu P, et al. Cell Res, 2013 May. PMID 23459151, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC30353

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA polymerase binding ISO
Inferred from Sequence Orthology
more info
  
enables G-rich strand telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of protein localization to telomere ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2/M transition checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2/M transition checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2/M transition checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of SOSS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SOSS complex ISO
Inferred from Sequence Orthology
more info
  
part_of SOSS complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SOSS complex subunit B1
Names
SOSS-B1
oligonucleotide/oligosaccharide-binding fold containing 2B
oligonucleotide/oligosaccharide-binding fold-containing protein 2B
sensor of single-strand DNA complex subunit B1
sensor of ssDNA subunit B1
single-stranded DNA-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358972.1 → NP_001345901.1  SOSS complex subunit B1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC090489, BE988804, BX519720, CX238225
    Consensus CDS
    CCDS24276.1
    UniProtKB/Swiss-Prot
    Q8R2Y9
    UniProtKB/TrEMBL
    E9Q199
    Conserved Domains (2) summary
    PRK14971
    Location:106 → 179
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:18 → 95
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

  2. NM_001358973.1 → NP_001345902.1  SOSS complex subunit B1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090489, BE988804, BX519720, CX238225
    Conserved Domains (1) summary
    PRK14971
    Location:7 → 80
    PRK14971; DNA polymerase III subunit gamma/tau

  3. NM_027257.2 → NP_081533.1  SOSS complex subunit B1 isoform 1

    See identical proteins and their annotated locations for NP_081533.1

    Status: VALIDATED

    Source sequence(s)
    BE988804, BX519720, BY250791, CX238225
    Consensus CDS
    CCDS24276.1
    UniProtKB/Swiss-Prot
    Q8R2Y9
    UniProtKB/TrEMBL
    E9Q199
    Related
    ENSMUSP00000026439.8, ENSMUST00000026439.14
    Conserved Domains (2) summary
    PRK14971
    Location:106 → 179
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:18 → 95
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128237263..128247426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514067.4 → XP_006514130.1  SOSS complex subunit B1 isoform X1

    See identical proteins and their annotated locations for XP_006514130.1

    UniProtKB/Swiss-Prot
    Q8R2Y9
    UniProtKB/TrEMBL
    E9Q199
    Conserved Domains (2) summary
    PRK14971
    Location:106 → 179
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:18 → 95
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

  2. XM_036155988.1 → XP_036011881.1  SOSS complex subunit B1 isoform X1

    UniProtKB/Swiss-Prot
    Q8R2Y9
    UniProtKB/TrEMBL
    E9Q199
    Conserved Domains (2) summary
    PRK14971
    Location:106 → 179
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:18 → 95
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

  3. XM_006514066.4 → XP_006514129.1  SOSS complex subunit B1 isoform X1

    See identical proteins and their annotated locations for XP_006514129.1

    UniProtKB/Swiss-Prot
    Q8R2Y9
    UniProtKB/TrEMBL
    E9Q199
    Conserved Domains (2) summary
    PRK14971
    Location:106 → 179
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:18 → 95
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

  4. XM_030245253.2 → XP_030101113.1  SOSS complex subunit B1 isoform X1

    UniProtKB/Swiss-Prot
    Q8R2Y9
    UniProtKB/TrEMBL
    E9Q199
    Related
    ENSMUSP00000128634.2, ENSMUST00000164199.8
    Conserved Domains (2) summary
    PRK14971
    Location:106 → 179
    PRK14971; DNA polymerase III subunit gamma/tau
    cd04491
    Location:18 → 95
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...

  5. XM_030245254.2 → XP_030101114.1  SOSS complex subunit B1 isoform X2

    Conserved Domains (1) summary
    PRK14971
    Location:7 → 80
    PRK14971; DNA polymerase III subunit gamma/tau
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2Y9.1 GenPept UniProtKB/Swiss-Prot:Q8R2Y9

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