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Cmtm8 CKLF-like MARVEL transmembrane domain containing 8 [ Mus musculus (house mouse) ]

Gene ID: 70031, updated on 2-Nov-2024

Summary

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Official Symbol
Cmtm8provided by MGI
Official Full Name
CKLF-like MARVEL transmembrane domain containing 8provided by MGI
Primary source
MGI:MGI:2447167
See related
Ensembl:ENSMUSG00000041012 AllianceGenome:MGI:2447167
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cklfsf8; 2700018N07Rik
Summary
Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in nucleoplasm. Predicted to be active in membrane. Is expressed in several structures, including adenohypophysis; gut; nasal cavity epithelium; respiratory system; and ventricular layer. Orthologous to human CMTM8 (CKLF like MARVEL transmembrane domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver adult (RPKM 55.0), lung adult (RPKM 54.8) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Cmtm8 in Genome Data Viewer
Location:
9 F3; 9 65.2 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (114618411..114673220, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (114789343..114844152, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2310 Neighboring gene CKLF-like MARVEL transmembrane domain containing 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:114662028-114662553 Neighboring gene CKLF-like MARVEL transmembrane domain containing 7 Neighboring gene STARR-seq mESC enhancer starr_25390 Neighboring gene STARR-seq mESC enhancer starr_25391 Neighboring gene predicted gene, 23889 Neighboring gene predicted gene, 30448 Neighboring gene glycerol-3-phosphate dehydrogenase 1-like Neighboring gene STARR-positive B cell enhancer ABC_E6808

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Han W, et al. Genomics, 2003 Jun. PMID 12782130
  2. Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Metzakopian E, et al. Development, 2012 Jul. PMID 22696295, Free PMC Article
  3. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in myelination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
CKLF-like MARVEL transmembrane domain-containing protein 8
Names
chemokine-like factor super family 8
chemokine-like factor superfamily member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027294.2 → NP_081570.1  CKLF-like MARVEL transmembrane domain-containing protein 8

    See identical proteins and their annotated locations for NP_081570.1

    Status: PROVISIONAL

    Source sequence(s)
    AK012262
    Consensus CDS
    CCDS23597.1
    UniProtKB/Swiss-Prot
    Q9CZR4
    Related
    ENSMUSP00000043706.4, ENSMUST00000047013.4
    Conserved Domains (1) summary
    pfam01284
    Location:36 → 162
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    114618411..114673220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242999.3 → XP_011241301.1  CKLF-like MARVEL transmembrane domain-containing protein 8 isoform X1

    Conserved Domains (1) summary
    pfam01284
    Location:1 → 89
    MARVEL; Membrane-associating domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZR4.1 GenPept UniProtKB/Swiss-Prot:Q9CZR4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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