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Smc4 structural maintenance of chromosomes 4 [ Mus musculus (house mouse) ]

Gene ID: 70099, updated on 2-Nov-2024

Summary

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Official Symbol
Smc4provided by MGI
Official Full Name
structural maintenance of chromosomes 4provided by MGI
Primary source
MGI:MGI:1917349
See related
Ensembl:ENSMUSG00000034349 AllianceGenome:MGI:1917349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SMC-4; Smc4l1; 2500002A22Rik
Summary
Enables chromatin binding activity and single-stranded DNA binding activity. Involved in positive regulation of chromosome segregation and positive regulation of chromosome separation. Acts upstream of or within kinetochore organization; meiotic chromosome condensation; and meiotic chromosome segregation. Located in chromosome, centromeric region and condensed nuclear chromosome. Part of condensin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human SMC4 (structural maintenance of chromosomes 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 30.9), CNS E11.5 (RPKM 28.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Smc4 in Genome Data Viewer
Location:
3 E1; 3 32.14 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (68912071..68941956)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (69004738..69034623)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110032F04 gene Neighboring gene STARR-seq mESC enhancer starr_07914 Neighboring gene intraflagellar transport 80 Neighboring gene oxysterol binding protein-like 9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07915 Neighboring gene STARR-seq mESC enhancer starr_07916 Neighboring gene STARR-seq mESC enhancer starr_07917 Neighboring gene STARR-positive B cell enhancer ABC_E3436 Neighboring gene microRNA 16-2 Neighboring gene microRNA 15b Neighboring gene tripartite motif-containing 59 Neighboring gene RIKEN cDNA 9630025H16 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Strunnikov AV, et al. Eur J Biochem, 1999 Jul. PMID 10429180
  2. Shaping the metaphase chromosome: coordination of cohesion and condensation. Losada A, et al. Bioessays, 2001 Oct. PMID 11598959
  3. The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity. Sun X, et al. Cell Metab, 2023 Sep 5. PMID 37543034
  4. Structural Maintenance of Chromosome Protein 4 Promotes the Progression of Cardia Adenocarcinoma via Regulation of the Wnt/β-catenin Signaling Pathway. Zhu M, et al. Comb Chem High Throughput Screen, 2024. PMID 37170988
  5. Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia. Peng L, et al. Leuk Lymphoma, 2018 Oct. PMID 29043883

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural Maintenance of Chromosome Protein 4 Promotes the Progression of Cardia Adenocarcinoma via Regulation of the Wnt/beta-catenin Signaling Pathway.
    Title: Structural Maintenance of Chromosome Protein 4 Promotes the Progression of Cardia Adenocarcinoma via Regulation of the Wnt/β-catenin Signaling Pathway.
  2. TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway.
    Title: TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway.
  3. Study examined the expression of SMC4 in acute myeloid leukemia (AML) pediatric patients cells and normal cells and revealed that SMC4 was significantly higher than control. Utilizing SMC4 gene knockdown in the established MLL-AF9 AML mouse model study found that SMC4 knockdown inhibited AML progression by maintaining leukemia stem cells.
    Title: Structural maintenance of chromosomes 4 is required for leukemia stem cell maintenance in MLL-AF9 induced acute myeloid leukemia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within kinetochore organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic chromosome condensation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of chromosome condensation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in single strand break repair TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of condensin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of condensin complex ISO
Inferred from Sequence Orthology
more info
  
part_of condensin complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of condensin complex TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
structural maintenance of chromosomes protein 4
Names
SMC protein 4
SMC4 structural maintenance of chromosomes 4-like 1
XCAP-C homolog
chromosome-associated polypeptide C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356976.1 → NP_001343905.1  structural maintenance of chromosomes protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122876, BC062939
    UniProtKB/TrEMBL
    E9Q2X6, Q6P7V9
    Conserved Domains (1) summary
    pfam02463
    Location:11 → 1202
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_133786.4 → NP_598547.1  structural maintenance of chromosomes protein 4 isoform 1

    See identical proteins and their annotated locations for NP_598547.1

    Status: VALIDATED

    Source sequence(s)
    AC122876, BC062939, CN722683
    Consensus CDS
    CCDS17401.1
    UniProtKB/Swiss-Prot
    Q8BTS7, Q8BTY9, Q8CG47, Q99K21
    UniProtKB/TrEMBL
    E9Q2X6
    Related
    ENSMUSP00000047872.9, ENSMUST00000042901.15
    Conserved Domains (1) summary
    pfam02463
    Location:81 → 1272
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    68912071..68941956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252813.2 → XP_030108673.1  structural maintenance of chromosomes protein 4 isoform X3

    UniProtKB/TrEMBL
    E9Q2X6
    Conserved Domains (1) summary
    COG1196
    Location:11 → 1042
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_006502046.3 → XP_006502109.1  structural maintenance of chromosomes protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006502109.1

    UniProtKB/Swiss-Prot
    Q8BTS7, Q8BTY9, Q8CG47, Q99K21
    UniProtKB/TrEMBL
    E9Q2X6
    Conserved Domains (1) summary
    pfam02463
    Location:81 → 1272
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_030252812.2 → XP_030108672.1  structural maintenance of chromosomes protein 4 isoform X2

    UniProtKB/TrEMBL
    E9Q2X6, Q6P7V9
    Conserved Domains (1) summary
    pfam02463
    Location:11 → 1202
    SMC_N; RecF/RecN/SMC N terminal domain

  4. XM_036163300.1 → XP_036019193.1  structural maintenance of chromosomes protein 4 isoform X3

    UniProtKB/TrEMBL
    E9Q2X6
    Conserved Domains (1) summary
    COG1196
    Location:11 → 1042
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  5. XM_036163301.1 → XP_036019194.1  structural maintenance of chromosomes protein 4 isoform X3

    UniProtKB/TrEMBL
    E9Q2X6
    Conserved Domains (1) summary
    COG1196
    Location:11 → 1042
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CG47.1 GenPept UniProtKB/Swiss-Prot:Q8CG47

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