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Znhit1 zinc finger, HIT domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 70103, updated on 2-Nov-2024

Summary

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Official Symbol
Znhit1provided by MGI
Official Full Name
zinc finger, HIT domain containing 1provided by MGI
Primary source
MGI:MGI:1917353
See related
Ensembl:ENSMUSG00000059518 AllianceGenome:MGI:1917353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZNFN4A1; 2700001K05Rik
Summary
Enables chromatin binding activity and histone deacetylase binding activity. Involved in several processes, including hematopoietic stem cell homeostasis; intestinal stem cell homeostasis; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within negative regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; and regulation of T cell proliferation. Located in nucleus. Is expressed in cardiac muscle tissue; heart; lens; lens epithelium; and lens fiber. Orthologous to human ZNHIT1 (zinc finger HIT-type containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 63.4), adrenal adult (RPKM 44.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Znhit1 in Genome Data Viewer
Location:
5 G2; 5 76.09 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137011048..137016813, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (136982194..136987959, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10358 Neighboring gene fission, mitochondrial 1 Neighboring gene claudin 15 Neighboring gene STARR-positive B cell enhancer ABC_E4795 Neighboring gene procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 Neighboring gene microRNA 702 Neighboring gene 2-acylglycerol O-acyltransferase 2-A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy. Shi Y, et al. JCI Insight, 2022 Mar 22. PMID 35167494, Free PMC Article
  2. Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression. Sun S, et al. Dev Cell, 2022 Apr 11. PMID 35413238
  3. Mis-expression of GATA6 re-programs cell fate during early hematopoiesis. Audiger C, et al. Cell Rep, 2024 May 28. PMID 38676923
  4. Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers. Sun S, et al. Leukemia, 2020 Dec. PMID 32694618, Free PMC Article
  5. Znhit1 causes cell cycle arrest and down-regulates CDK6 expression. Yang Z, et al. Biochem Biophys Res Commun, 2009 Aug 14. PMID 19501046

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching.
    Title: Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching.
  2. Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation.
    Title: Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation.
  3. Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression.
    Title: Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression.
  4. Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy.
    Title: Critical role of Znhit1 for postnatal heart function and vacuolar cardiomyopathy.
  5. Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers.
    Title: Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers.
  6. Znhit1 promotes the interaction between H2A.Z and YL1 (H2A.Z chaperone) by controlling YL1 phosphorylation. These results demonstrate that Znhit1/H2A.Z is essential for Lgr5+ stem cell maintenance and intestinal homeostasis.
    Title: Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation.
  7. These results identify SRCAP/H2A.Z-mediated chromatin remodelling as a key early event in muscle differentiation-specific gene expression.
    Title: Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.
  8. These findings identified Znhit1 as a CDK6 regulator that plays an important role in cell proliferation.
    Title: Znhit1 causes cell cycle arrest and down-regulates CDK6 expression.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heart process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of G0 to G1 transition IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of lymphoid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription initiation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger HIT domain-containing protein 1
Names
p18 Hamlet
zinc finger protein, subfamily 4A (HIT domain containing), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310747.1 → NP_001297676.1  zinc finger HIT domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001297676.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) has a longer, distinct N-terminus than isoform 1.
    Source sequence(s)
    AA002885, AI426440, AI841783, BY084904
    Consensus CDS
    CCDS80438.1
    UniProtKB/Swiss-Prot
    Q8R331, Q9CZS6
    UniProtKB/TrEMBL
    G8JL39
    Related
    ENSMUSP00000083103.6, ENSMUST00000085941.12
    Conserved Domains (2) summary
    pfam04438
    Location:113 → 140
    zf-HIT; HIT zinc finger
    cl02154
    Location:79 → 135
    YL1_C; YL1 nuclear protein C-terminal domain

  2. NM_001310748.1 → NP_001297677.1  zinc finger HIT domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001297677.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (3) has a longer, distinct N-terminus than isoform 1.
    Source sequence(s)
    AC147987
    Consensus CDS
    CCDS80437.1
    UniProtKB/TrEMBL
    D3YZ33, G8JL39
    Related
    ENSMUSP00000106720.2, ENSMUST00000111091.8
    Conserved Domains (2) summary
    pfam04438
    Location:117 → 144
    zf-HIT; HIT zinc finger
    cl02154
    Location:83 → 139
    YL1_C; YL1 nuclear protein C-terminal domain

  3. NM_027318.4 → NP_081594.1  zinc finger HIT domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_081594.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shortest isoform (1).
    Source sequence(s)
    AI841783, AK080799, CX202132
    Consensus CDS
    CCDS39329.1
    UniProtKB/TrEMBL
    A0A0R4J1S6, D3YZ34
    Related
    ENSMUSP00000115929.2, ENSMUST00000156963.8
    Conserved Domains (2) summary
    pfam04438
    Location:112 → 139
    zf-HIT; HIT zinc finger
    cl02154
    Location:78 → 134
    YL1_C; YL1 nuclear protein C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137011048..137016813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504497.5 → XP_006504560.1  zinc finger HIT domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006504560.1

    UniProtKB/TrEMBL
    D3YZ33, G8JL39
    Conserved Domains (2) summary
    pfam04438
    Location:117 → 144
    zf-HIT; HIT zinc finger
    cl02154
    Location:83 → 139
    YL1_C; YL1 nuclear protein C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R331.1 GenPept UniProtKB/Swiss-Prot:Q8R331

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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