Srrd SRR1 domain containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srrdprovided by MGI
Official Full Name: SRR1 domain containingprovided by MGI
Primary source: MGI:MGI:1917368
See related: Ensembl:ENSMUSG00000029346 AllianceGenome:MGI:1917368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Srr1; 2810002G02Rik
Summary: Involved in regulation of circadian rhythm and regulation of heme biosynthetic process. Located in cytoplasm. Is expressed in genitourinary system. Orthologous to human SRRD (SRR1 domain containing). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 28.0), ovary adult (RPKM 22.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 54.69 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (112485257..112490921, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (112337391..112343040, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of SRRD was dependent on heme biosynthesis, and increased the production of heme. SRRD was expressed under circadian rhythms, and influenced the expression of clock genes including PER2, BMAL1, and CLOCK.
Title: The novel heme-dependent inducible protein, SRRD regulates heme biosynthesis and circadian rhythms.

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General gene information

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Markers

AW046167 (e-PCR)
- UniSTS:179237

AF097181 (e-PCR)
- UniSTS:163368

NoName (e-PCR)
- UniSTS:490570

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in heme biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SRR1-like protein

Names: SRR1 domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359388.1 → NP_001346317.1 SRR1-like protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC123848

UniProtKB/TrEMBL

F6Q7H5

Related

ENSMUSP00000119870.2, ENSMUST00000146510.8

Conserved Domains (1) summary

cl06844
Location:111 → 225

SRR1; SRR1
NM_027323.2 → NP_081599.2 SRR1-like protein isoform 2

See identical proteins and their annotated locations for NP_081599.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK012640, AV513732, BC030678, BY291840

Consensus CDS

CCDS51614.1

UniProtKB/Swiss-Prot

Q08AU8, Q8K2M3, Q9CSK3

Related

ENSMUSP00000031289.7, ENSMUST00000031289.7

Conserved Domains (1) summary

cl06844
Location:111 → 225

SRR1; SRR1

RNA

NR_153105.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC123848, BQ179086
NR_153106.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC123848