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BDNF brain derived neurotrophic factor [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 701245, updated on 17-Aug-2024

Summary

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Official Symbol
BDNFprovided by VGNC
Official Full Name
brain derived neurotrophic factorprovided by VGNC
Primary source
VGNC:VGNC:99552
Locus tag
EGK_06399
See related
Ensembl:ENSMMUG00000008634
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See BDNF in Genome Data Viewer
Location:
chromosome: 14
Exon count:
6
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 14 NC_041767.1 (37727375..37797626)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 14 NC_027906.1 (38238851..38309109)

Chromosome 14 - NC_041767.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 18A Neighboring gene chromobox protein homolog 3 pseudogene Neighboring gene uncharacterized LOC114672299 Neighboring gene lin-7 homolog C, crumbs cell polarity complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques. Cirulli F, et al. Psychoneuroendocrinology, 2011 Apr. PMID 21145664, Free PMC Article
  2. Heterogeneity of the developmental patterns of neurotrophin protein levels among neocortical areas of macaque monkeys. Mori T, et al. Exp Brain Res, 2006 May. PMID 16307254
  3. Molecular correlates of spontaneous activity in non-human primates. Mitchell AC, et al. J Neural Transm (Vienna), 2010 Dec. PMID 20838826, Free PMC Article
  4. Comparison of mammalian, chicken and Xenopus brain-derived neurotrophic factor coding sequences. Isackson PJ, et al. FEBS Lett, 1991 Jul 22. PMID 1906813
  5. Adolescent testosterone influences BDNF and TrkB mRNA and neurotrophin-interneuron marker relationships in mammalian frontal cortex. Purves-Tyson TD, et al. Schizophr Res, 2015 Nov. PMID 26088421

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study showed that complex relationships exist between BDNF/TrkB gene expression and interneuron marker gene expression that appear to be dependent on the presence of testosterone at adolescence
    Title: Adolescent testosterone influences BDNF and TrkB mRNA and neurotrophin-interneuron marker relationships in mammalian frontal cortex.
  2. In a monkey model, cortical BDNF and activity regulated cytoskeletal-associated protein ARC expressions are strongly correlated with spontaneous physical activity.
    Title: Molecular correlates of spontaneous activity in non-human primates.
  3. A SNP is present in rhesus macaques and is able to affect BDNF peripheral levels, thus making this primate model a fundamental tool to study gene by environment interactions involving the BDNF gene.
    Title: A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques.
  4. In monkey the decline of the BDNF protein level started earlier in the sensory and motor neocortical areas than in the association neocortical areas.
    Title: Heterogeneity of the developmental patterns of neurotrophin protein levels among neocortical areas of macaque monkeys.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nerve growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nerve development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nerve growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of collateral sprouting IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
brain-derived neurotrophic factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041767.1 Reference Mmul_10 Primary Assembly

    Range
    37727375..37797626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015114599.2 → XP_014970085.1  brain-derived neurotrophic factor isoform X2

    UniProtKB/TrEMBL
    I2CTP4
    Conserved Domains (1) summary
    smart00140
    Location:141 → 248
    NGF; Nerve growth factor (NGF or beta-NGF)

  2. XM_015114601.2 → XP_014970087.1  brain-derived neurotrophic factor isoform X3

    UniProtKB/TrEMBL
    A0A1D5Q8B8, A0A1D5R4M8, A0A8J8YBY4, F7F914, H9F8C5
    Related
    ENSMMUP00000055264.2, ENSMMUT00000078167.2
    Conserved Domains (1) summary
    smart00140
    Location:133 → 240
    NGF; Nerve growth factor (NGF or beta-NGF)

  3. XM_015114600.2 → XP_014970086.1  brain-derived neurotrophic factor isoform X3

    UniProtKB/TrEMBL
    A0A1D5Q8B8, A0A1D5R4M8, A0A8J8YBY4, F7F914, H9F8C5
    Related
    ENSMMUP00000044286.2, ENSMMUT00000061569.2
    Conserved Domains (1) summary
    smart00140
    Location:133 → 240
    NGF; Nerve growth factor (NGF or beta-NGF)

  4. XM_015114602.2 → XP_014970088.1  brain-derived neurotrophic factor isoform X4

    Conserved Domains (1) summary
    smart00140
    Location:162 → 269
    NGF; Nerve growth factor (NGF or beta-NGF)

  5. XM_015114598.2 → XP_014970084.1  brain-derived neurotrophic factor isoform X1

    UniProtKB/TrEMBL
    A0A1D5QAT2
    Related
    ENSMMUP00000045150.1, ENSMMUT00000056857.2
    Conserved Domains (1) summary
    smart00140
    Location:190 → 297
    NGF; Nerve growth factor (NGF or beta-NGF)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06225.1 GenPept UniProtKB/Swiss-Prot:Q06225

Gene LinkOut

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Molecular Biology Databases
Research Materials