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Tmt1a thiol methyltransferase 1A1 [ Mus musculus (house mouse) ]

Gene ID: 70152, updated on 2-Nov-2024

Summary

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Official Symbol
Tmt1aprovided by MGI
Official Full Name
thiol methyltransferase 1A1provided by MGI
Primary source
MGI:MGI:1916523
See related
Ensembl:ENSMUSG00000054619 AllianceGenome:MGI:1916523
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aam-B; UbiE1; Mettl7a; Mettl7a1; 2210414H16Rik; 3300001H21Rik
Summary
Predicted to enable mRNA m(6)A methyltransferase activity and thiol S-methyltransferase activity. Predicted to be involved in lncRNA processing; odontogenesis; and osteoblast differentiation. Predicted to be located in endoplasmic reticulum and lipid droplet. Orthologous to human TMT1A (thiol methyltransferase 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lung adult (RPKM 144.1), kidney adult (RPKM 109.2) and 14 other tissues See more
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Genomic context

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See Tmt1a in Genome Data Viewer
Location:
15 F1; 15 56.25 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100201969..100227882)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100304145..100330001)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39747 Neighboring gene transmembrane (C-terminal) protease, serine 12 Neighboring gene predicted gene, 33666 Neighboring gene STARR-positive B cell enhancer ABC_E9423 Neighboring gene predicted gene, 53910 Neighboring gene thiol methyltransferase 1A3 Neighboring gene methyltransferase hypoxia inducible domain containing 1 Neighboring gene thiol methyltransferase 1A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LncRNA EPR-induced METTL7A1 modulates target gene translation. Briata P, et al. Nucleic Acids Res, 2022 Jul 22. PMID 35748870, Free PMC Article
  2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA EPR-induced METTL7A1 modulates target gene translation.
    Title: LncRNA EPR-induced METTL7A1 modulates target gene translation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA m(6)A methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiol S-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lncRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in odontogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methyltransferase-like protein 7A
Names
methyltransferase like 7A
methyltransferase like 7A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027334.3 → NP_081610.2  methyltransferase-like protein 7A

    See identical proteins and their annotated locations for NP_081610.2

    Status: PROVISIONAL

    Source sequence(s)
    AK076169
    Consensus CDS
    CCDS27833.1
    UniProtKB/TrEMBL
    Q5K4Q9, Q8C6B0
    Related
    ENSMUSP00000065271.4, ENSMUST00000067752.5
    Conserved Domains (2) summary
    COG0500
    Location:70 → 187
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam08241
    Location:75 → 172
    Methyltransf_11; Methyltransferase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    100201969..100227882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521389.2 → XP_006521452.1  methyltransferase-like protein 7A isoform X1

    UniProtKB/TrEMBL
    Q5K4Q9
    Related
    ENSMUSP00000155621.2, ENSMUST00000230472.2
    Conserved Domains (1) summary
    pfam08241
    Location:57 → 154
    Methyltransf_11; Methyltransferase domain

  2. XM_006521390.5 → XP_006521453.1  methyltransferase-like protein 7A isoform X3

    UniProtKB/TrEMBL
    Q76I24
    Conserved Domains (1) summary
    pfam08241
    Location:30 → 127
    Methyltransf_11; Methyltransferase domain

  3. XM_011245728.2 → XP_011244030.1  methyltransferase-like protein 7A isoform X2

    See identical proteins and their annotated locations for XP_011244030.1

    UniProtKB/TrEMBL
    H3BJI7, Q9D7S5
    Related
    ENSMUSP00000155112.2, ENSMUST00000229588.2
    Conserved Domains (1) summary
    pfam08241
    Location:75 → 166
    Methyltransf_11; Methyltransferase domain
Nucleotide Protein Strain
Heading Accession and Version

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