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Bag5 BCL2-associated athanogene 5 [ Mus musculus (house mouse) ]

Gene ID: 70369, updated on 2-Nov-2024

Summary

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Official Symbol
Bag5provided by MGI
Official Full Name
BCL2-associated athanogene 5provided by MGI
Primary source
MGI:MGI:1917619
See related
Ensembl:ENSMUSG00000049792 AllianceGenome:MGI:1917619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bag-5; 1600025G07Rik; 4930405J06Rik
Summary
Predicted to enable adenyl-nucleotide exchange factor activity; enzyme binding activity; and protein-folding chaperone binding activity. Predicted to be involved in several processes, including negative regulation of protein metabolic process; negative regulation of protein refolding; and protein stabilization. Part of junctional membrane complex. Used to study dilated cardiomyopathy 2F. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 2F. Orthologous to human BAG5 (BAG cochaperone 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 180.4), CNS E11.5 (RPKM 14.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Bag5 in Genome Data Viewer
Location:
12 F1; 12 61.11 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111675922..111679690, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111709488..111713256, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1606 Neighboring gene predicted gene, 51961 Neighboring gene predicted gene, 36635 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene STARR-seq mESC enhancer starr_33333 Neighboring gene STARR-positive B cell enhancer ABC_E7188 Neighboring gene kinesin light chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E209 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene zinc finger, FYVE domain containing 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Bag5 protects neuronal cells from amyloid β-induced cell death. Guo K, et al. J Mol Neurosci, 2015 Apr. PMID 25367796
  2. A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia. Wongong R, et al. Sci Rep, 2024 May 25. PMID 38796549, Free PMC Article
  3. BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly. Gan S, et al. EMBO Rep, 2024 Apr. PMID 38454159, Free PMC Article
  4. Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch. Bracho-Valdés I, et al. Int J Mol Sci, 2023 Dec 15. PMID 38139359, Free PMC Article
  5. Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation. Hakui H, et al. Sci Transl Med, 2022 Jan 19. PMID 35044787

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia.
    Title: A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia.
  2. BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly.
    Title: BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly.
  3. Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch.
    Title: Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch.
  4. knockdown of Bag5 exacerbated Abeta1-42-induced apoptosis.
    Title: Bag5 protects neuronal cells from amyloid β-induced cell death.
  5. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation.
    Title: BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation.
  6. Bcl-2-associated athanogene 5 (BAG5) is a negative regulator of both Hsp70 and parkin function that sensitizes dopaminergic neurons to injury-induced death.
    Title: BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of protein refolding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein refolding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inclusion body assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inclusion body assembly ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
  
located_in inclusion body ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of junctional membrane complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
BAG family molecular chaperone regulator 5
Names
BAG-family molecular chaperone regulator-5 (BAG-5)
bcl-2-associated athanogene 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324480.1 → NP_001311409.1  BAG family molecular chaperone regulator 5

    Status: VALIDATED

    Source sequence(s)
    AC152065, AK160246, BC055762, CJ046703
    Consensus CDS
    CCDS26185.1
    UniProtKB/Swiss-Prot
    Q3TVA8, Q8CI32, Q8K175, Q9DAU0
    Related
    ENSMUSP00000125183.2, ENSMUST00000160576.2
    Conserved Domains (1) summary
    smart00264
    Location:9 → 86
    BAG; BAG domains, present in regulator of Hsp70 proteins

  2. NM_001324481.1 → NP_001311410.1  BAG family molecular chaperone regulator 5

    Status: VALIDATED

    Source sequence(s)
    AK160246, BC055762, CJ046703
    Consensus CDS
    CCDS26185.1
    UniProtKB/Swiss-Prot
    Q3TVA8, Q8CI32, Q8K175, Q9DAU0
    Conserved Domains (1) summary
    smart00264
    Location:9 → 86
    BAG; BAG domains, present in regulator of Hsp70 proteins

  3. NM_001324482.1 → NP_001311411.1  BAG family molecular chaperone regulator 5

    Status: VALIDATED

    Source sequence(s)
    AC152065, AK160246, BC055762, CJ047026
    Consensus CDS
    CCDS26185.1
    UniProtKB/Swiss-Prot
    Q3TVA8, Q8CI32, Q8K175, Q9DAU0
    Conserved Domains (1) summary
    smart00264
    Location:9 → 86
    BAG; BAG domains, present in regulator of Hsp70 proteins

  4. NM_027404.2 → NP_081680.1  BAG family molecular chaperone regulator 5

    See identical proteins and their annotated locations for NP_081680.1

    Status: VALIDATED

    Source sequence(s)
    AC152065, BC055762, CX243791
    Consensus CDS
    CCDS26185.1
    UniProtKB/Swiss-Prot
    Q3TVA8, Q8CI32, Q8K175, Q9DAU0
    Related
    ENSMUSP00000051049.7, ENSMUST00000054636.7
    Conserved Domains (1) summary
    smart00264
    Location:9 → 86
    BAG; BAG domains, present in regulator of Hsp70 proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111675922..111679690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516217.5 → XP_006516280.1  BAG family molecular chaperone regulator 5 isoform X1

    See identical proteins and their annotated locations for XP_006516280.1

    UniProtKB/Swiss-Prot
    Q3TVA8, Q8CI32, Q8K175, Q9DAU0
    Conserved Domains (1) summary
    smart00264
    Location:9 → 86
    BAG; BAG domains, present in regulator of Hsp70 proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CI32.1 GenPept UniProtKB/Swiss-Prot:Q8CI32

Gene LinkOut

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