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ARHGEF28 Rho guanine nucleotide exchange factor 28 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 703897, updated on 17-Aug-2024

Summary

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Official Symbol
ARHGEF28provided by VGNC
Official Full Name
Rho guanine nucleotide exchange factor 28provided by VGNC
Primary source
VGNC:VGNC:84279
See related
Ensembl:ENSMMUG00000017897
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as
RGNEF
Orthologs
human mouse all
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Genomic context

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See ARHGEF28 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
37
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 6 NC_041759.1 (70543215..70794480)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 6 NC_027898.1 (70322927..70574670)

Chromosome 6 - NC_041759.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat family A member 2 Neighboring gene UTP15 small subunit processome component Neighboring gene ATP synthase-coupling factor 6, mitochondrial-like Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC106998798 Neighboring gene uncharacterized LOC114678688

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 28
Names
190 kDa guanine nucleotide exchange factor
Rho guanine nucleotide exchange factor (GEF) 28
Rho-guanine nucleotide exchange factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041759.1 Reference Mmul_10 Primary Assembly

    Range
    70543215..70794480
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_028849510.1 → XP_028705343.1  rho guanine nucleotide exchange factor 28 isoform X4

    UniProtKB/TrEMBL
    G7MUQ8
    Conserved Domains (3) summary
    smart00325
    Location:851 → 1040
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00029
    Location:653 → 697
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14680
    Location:1085 → 1185
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

  2. XM_015140272.2 → XP_014995758.2  rho guanine nucleotide exchange factor 28 isoform X1

    UniProtKB/TrEMBL
    F7F1G4, G7MUQ8
    Related
    ENSMMUP00000023527.4, ENSMMUT00000025148.4
    Conserved Domains (3) summary
    smart00325
    Location:851 → 1040
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00029
    Location:653 → 697
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14680
    Location:1085 → 1185
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain

  3. XM_028849507.1 → XP_028705340.1  rho guanine nucleotide exchange factor 28 isoform X2

    UniProtKB/TrEMBL
    F7F119, G7MUQ8
    Related
    ENSMMUP00000023532.4, ENSMMUT00000025154.4
    Conserved Domains (3) summary
    smart00325
    Location:753 → 942
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00029
    Location:555 → 599
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cl17171
    Location:987 → 1087
    PH-like; Pleckstrin homology-like domain

  4. XM_028849509.1 → XP_028705342.1  rho guanine nucleotide exchange factor 28 isoform X3

    Conserved Domains (3) summary
    smart00325
    Location:538 → 727
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00029
    Location:340 → 384
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd14680
    Location:772 → 872
    PH_p190RhoGEF; Rho guanine nucleotide exchange factor Pleckstrin homology domain
Nucleotide Protein
Heading Accession and Version

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