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Ints2 integrator complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 70422, updated on 2-Nov-2024

Summary

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Official Symbol
Ints2provided by MGI
Official Full Name
integrator complex subunit 2provided by MGI
Primary source
MGI:MGI:1917672
See related
Ensembl:ENSMUSG00000018068 AllianceGenome:MGI:1917672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1287; 2810417D08Rik
Summary
Predicted to be involved in snRNA 3'-end processing. Predicted to be located in cytoplasm and nucleus. Predicted to be part of integrator complex. Orthologous to human INTS2 (integrator complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.9), CNS E14 (RPKM 7.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Ints2 in Genome Data Viewer
Location:
11 C; 11 51.71 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86101507..86148912, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86210681..86257609, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30261 Neighboring gene predicted gene, 20759 Neighboring gene BRCA1 interacting protein C-terminal helicase 1 Neighboring gene STARR-seq mESC enhancer starr_30264 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E1425 Neighboring gene BRCA1 interacting protein C-terminal helicase 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_30265 Neighboring gene mediator complex subunit 13 Neighboring gene predicted gene, 57586 Neighboring gene STARR-positive B cell enhancer ABC_E10702 Neighboring gene STARR-positive B cell enhancer ABC_E1837 Neighboring gene predicted gene, 38937

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease. Tkatchenko TV, et al. Physiol Genomics, 2009 Nov 6. PMID 19723774, Free PMC Article
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
  3. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  4. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
  5. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. characterization of the human Integrator complex
    Title: Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC141509

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in snRNA processing ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of integrator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
part_of integrator complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
integrator complex subunit 2
Names
int2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363129.1 → NP_001350058.1  integrator complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL592065
    Consensus CDS
    CCDS25198.1
    UniProtKB/Swiss-Prot
    Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
    UniProtKB/TrEMBL
    Q148R8
    Conserved Domains (1) summary
    pfam14750
    Location:24 → 1131
    INTS2; Integrator complex subunit 2

  2. NM_001363130.1 → NP_001350059.1  integrator complex subunit 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL592065, KY499705
    UniProtKB/TrEMBL
    A0A1S6GWJ5, Q148R8
    Related
    ENSMUSP00000103674.2, ENSMUST00000108039.8
    Conserved Domains (1) summary
    pfam14750
    Location:44 → 1151
    INTS2; Integrator complex subunit 2

  3. NM_027421.3 → NP_081697.2  integrator complex subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_081697.2

    Status: VALIDATED

    Source sequence(s)
    AK129323, AK164097, AL592065, BC059056, CF166557
    Consensus CDS
    CCDS25198.1
    UniProtKB/Swiss-Prot
    Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
    UniProtKB/TrEMBL
    Q148R8
    Related
    ENSMUSP00000018212.7, ENSMUST00000018212.13
    Conserved Domains (1) summary
    pfam14750
    Location:24 → 1131
    INTS2; Integrator complex subunit 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    86101507..86148912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534179.5 → XP_006534242.1  integrator complex subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_006534242.1

    UniProtKB/Swiss-Prot
    Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
    UniProtKB/TrEMBL
    Q148R8
    Conserved Domains (1) summary
    pfam14750
    Location:24 → 1131
    INTS2; Integrator complex subunit 2

  2. XM_006534180.4 → XP_006534243.1  integrator complex subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_006534243.1

    UniProtKB/Swiss-Prot
    Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
    UniProtKB/TrEMBL
    Q148R8
    Conserved Domains (1) summary
    pfam14750
    Location:24 → 1131
    INTS2; Integrator complex subunit 2

  3. XM_030246300.2 → XP_030102160.1  integrator complex subunit 2 isoform X3

    UniProtKB/Swiss-Prot
    Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
    UniProtKB/TrEMBL
    Q148R8
    Conserved Domains (1) summary
    pfam14750
    Location:24 → 1131
    INTS2; Integrator complex subunit 2

  4. XM_006534176.4 → XP_006534239.1  integrator complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006534239.1

    UniProtKB/TrEMBL
    A0A1S6GWJ5, Q148R8
    Conserved Domains (1) summary
    pfam14750
    Location:44 → 1151
    INTS2; Integrator complex subunit 2

  5. XM_006534178.5 → XP_006534241.1  integrator complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    Q148R8
    Conserved Domains (1) summary
    pfam14750
    Location:34 → 1141
    INTS2; Integrator complex subunit 2

  6. XM_006534181.5 → XP_006534244.1  integrator complex subunit 2 isoform X3

    See identical proteins and their annotated locations for XP_006534244.1

    UniProtKB/Swiss-Prot
    Q5SXZ5, Q5SXZ6, Q6PCY7, Q6ZPU6, Q80UK8, Q8CB15, Q9CSE0
    UniProtKB/TrEMBL
    Q148R8
    Conserved Domains (1) summary
    pfam14750
    Location:24 → 1131
    INTS2; Integrator complex subunit 2

  7. XM_006534177.5 → XP_006534240.1  integrator complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006534240.1

    UniProtKB/TrEMBL
    A0A1S6GWJ5, Q148R8
    Conserved Domains (1) summary
    pfam14750
    Location:44 → 1151
    INTS2; Integrator complex subunit 2

RNA

  1. XR_879737.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UK8.2 GenPept UniProtKB/Swiss-Prot:Q80UK8

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