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Gfod2 glucose-fructose oxidoreductase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 70575, updated on 2-Nov-2024

Summary

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Official Symbol
Gfod2provided by MGI
Official Full Name
glucose-fructose oxidoreductase domain containing 2provided by MGI
Primary source
MGI:MGI:1917825
See related
Ensembl:ENSMUSG00000013150 AllianceGenome:MGI:1917825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730466C23Rik
Summary
Predicted to enable nucleotide binding activity and oxidoreductase activity. Acts upstream of or within extracellular matrix organization. Located in extracellular matrix. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human GFOD2 (Gfo/Idh/MocA-like oxidoreductase domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 7.1), CNS E14 (RPKM 6.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Gfod2 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106440676..106485299, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105714044..105758666, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3798 Neighboring gene RIKEN cDNA 4933405L10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6678 Neighboring gene par-6 family cell polarity regulator alpha Neighboring gene enkurin domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E8850 Neighboring gene RAN binding protein 10 Neighboring gene STARR-positive B cell enhancer ABC_E2272 Neighboring gene translin-associated factor X (Tsnax) interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E2875 Neighboring gene centromere protein T

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
  2. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucose-fructose oxidoreductase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368385.1 → NP_001355314.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC152826
    Conserved Domains (1) summary
    COG0673
    Location:7 → 404
    MviM; Predicted dehydrogenase [General function prediction only]

  2. NM_001368386.1 → NP_001355315.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC152826
    Consensus CDS
    CCDS22612.1
    UniProtKB/Swiss-Prot
    Q9CYH5
    Conserved Domains (1) summary
    COG0673
    Location:7 → 364
    MviM; Predicted dehydrogenase [General function prediction only]

  3. NM_001368388.1 → NP_001355317.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC152826
    Conserved Domains (1) summary
    cl40708
    Location:18 → 293
    MviM; Predicted dehydrogenase [General function prediction only]

  4. NM_001368389.1 → NP_001355318.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC152826
    Conserved Domains (1) summary
    cl40708
    Location:18 → 293
    MviM; Predicted dehydrogenase [General function prediction only]

  5. NM_027469.5 → NP_081745.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_081745.1

    Status: VALIDATED

    Source sequence(s)
    AC152826
    Consensus CDS
    CCDS22612.1
    UniProtKB/Swiss-Prot
    Q9CYH5
    Related
    ENSMUSP00000013294.10, ENSMUST00000013294.16
    Conserved Domains (1) summary
    COG0673
    Location:7 → 364
    MviM; Predicted dehydrogenase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106440676..106485299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243753.2 → XP_030099613.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    cl40708
    Location:20 → 264
    MviM; Predicted dehydrogenase [General function prediction only]

  2. XM_036154282.1 → XP_036010175.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    cl40708
    Location:20 → 264
    MviM; Predicted dehydrogenase [General function prediction only]

  3. XM_011248499.4 → XP_011246801.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011246801.1

    Conserved Domains (1) summary
    COG0673
    Location:7 → 404
    MviM; Predicted dehydrogenase [General function prediction only]

  4. XM_036154281.1 → XP_036010174.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    cl40708
    Location:18 → 293
    MviM; Predicted dehydrogenase [General function prediction only]

  5. XM_006531348.5 → XP_006531411.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006531411.1

    Conserved Domains (1) summary
    COG0673
    Location:7 → 404
    MviM; Predicted dehydrogenase [General function prediction only]

  6. XM_017312958.3 → XP_017168447.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9CYH5
    Conserved Domains (1) summary
    COG0673
    Location:7 → 364
    MviM; Predicted dehydrogenase [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYH5.1 GenPept UniProtKB/Swiss-Prot:Q9CYH5

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