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Zdhhc24 zinc finger, DHHC domain containing 24 [ Mus musculus (house mouse) ]

Gene ID: 70605, updated on 18-Sep-2024

Summary

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Official Symbol
Zdhhc24provided by MGI
Official Full Name
zinc finger, DHHC domain containing 24provided by MGI
Primary source
MGI:MGI:1917855
See related
Ensembl:ENSMUSG00000006463 AllianceGenome:MGI:1917855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Leng4; 5730496N17Rik
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including brain; early conceptus; endocrine gland; genitourinary system; and spinal cord mantle layer. Orthologous to human ZDHHC24 (zinc finger DHHC-type containing 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 20.6), ovary adult (RPKM 13.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zdhhc24 in Genome Data Viewer
Location:
19 A; 19 4.13 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4928696..4935425)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4878668..4885397)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cathepsin F Neighboring gene actinin alpha 3 Neighboring gene STARR-positive B cell enhancer ABC_E3236 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene STARR-seq mESC enhancer starr_45368 Neighboring gene dipeptidylpeptidase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable palmitoyltransferase ZDHHC24
Names
DHHC-24
leukocyte receptor cluster (LRC) member 4
zinc finger DHHC domain-containing protein 24
NP_001161988.1
NP_001161989.1
NP_081752.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168516.1 → NP_001161988.1  probable palmitoyltransferase ZDHHC24 isoform b

    See identical proteins and their annotated locations for NP_001161988.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC141437, CA559443, CD354313
    UniProtKB/TrEMBL
    Q3TA22
    Related
    ENSMUST00000162088.8

  2. NM_001168517.1 → NP_001161989.1  probable palmitoyltransferase ZDHHC24 isoform b

    See identical proteins and their annotated locations for NP_001161989.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AC141437
    UniProtKB/TrEMBL
    Q3TA22
    Related
    ENSMUST00000162134.2

  3. NM_027476.3 → NP_081752.2  probable palmitoyltransferase ZDHHC24 isoform a

    See identical proteins and their annotated locations for NP_081752.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC141437, AK171568
    Consensus CDS
    CCDS50353.1
    UniProtKB/Swiss-Prot
    Q3TAY4, Q3TDF1, Q3TF09, Q6IR37, Q9CS66
    Related
    ENSMUSP00000006632.8, ENSMUST00000006632.8
    Conserved Domains (1) summary
    pfam01529
    Location:95 → 232
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4928696..4935425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IR37.2 GenPept UniProtKB/Swiss-Prot:Q6IR37

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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