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Naa30 N(alpha)-acetyltransferase 30, NatC catalytic subunit [ Mus musculus (house mouse) ]

Gene ID: 70646, updated on 2-Nov-2024

Summary

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Official Symbol
Naa30provided by MGI
Official Full Name
N(alpha)-acetyltransferase 30, NatC catalytic subunitprovided by MGI
Primary source
MGI:MGI:1922259
See related
Ensembl:ENSMUSG00000036282 AllianceGenome:MGI:1922259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nat12; 4930487N19Rik; 5730533P17Rik
Summary
Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be involved in protein stabilization. Predicted to be located in cytosol and nucleus. Predicted to be part of NatC complex. Orthologous to human NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.0), whole brain E14.5 (RPKM 7.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Naa30 in Genome Data Viewer
Location:
14 C1; 14 25.42 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (49409703..49428346)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (49172246..49190889)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene exocyst complex component 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:49686153-49686414 Neighboring gene adaptor-related protein complex 5, mu 1 subunit Neighboring gene VISTA enhancer mm1570 Neighboring gene STARR-seq mESC enhancer starr_36626 Neighboring gene ribosomal protein L19, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_36627 Neighboring gene coiled-coil domain containing 198 Neighboring gene STARR-seq mESC enhancer starr_36630 Neighboring gene solute carrier family 35, member F4 Neighboring gene STARR-seq mESC enhancer starr_36631 Neighboring gene predicted gene, 52146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  2. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptide alpha-N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide alpha-N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide alpha-N-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide-methionine-alpha-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatC complex ISO
Inferred from Sequence Orthology
more info
  
part_of NatC complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 30
Names
N-acetyltransferase 12
N-acetyltransferase MAK3 homolog
Nalpha acetyltransferase 30
natC catalytic subunit
NP_081768.2
XP_006519605.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027492.2 → NP_081768.2  N-alpha-acetyltransferase 30

    Status: VALIDATED

    Source sequence(s)
    AC154227, AK015640, BC158065
    Consensus CDS
    CCDS84137.1
    UniProtKB/Swiss-Prot
    B2RY23, Q7TN07, Q8CES0
    UniProtKB/TrEMBL
    B2RXP7
    Related
    ENSMUSP00000121679.2, ENSMUST00000153488.9
    Conserved Domains (2) summary
    COG0456
    Location:211 → 364
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:283 → 341
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    49409703..49428346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519542.5 → XP_006519605.1  N-alpha-acetyltransferase 30 isoform X1

    UniProtKB/TrEMBL
    B2RXP7
    Related
    ENSMUSP00000041450.6, ENSMUST00000037362.6
    Conserved Domains (1) summary
    COG0456
    Location:222 → 375
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081430.1: Suppressed sequence

    Description
    NM_001081430.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CES0.2 GenPept UniProtKB/Swiss-Prot:Q8CES0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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