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Nos1ap nitric oxide synthase 1 (neuronal) adaptor protein [ Mus musculus (house mouse) ]

Gene ID: 70729, updated on 2-Nov-2024

Summary

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Official Symbol
Nos1approvided by MGI
Official Full Name
nitric oxide synthase 1 (neuronal) adaptor proteinprovided by MGI
Primary source
MGI:MGI:1917979
See related
Ensembl:ENSMUSG00000038473 AllianceGenome:MGI:1917979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Capon; 6330408P19Rik
Summary
Enables nitric-oxide synthase binding activity. Predicted to be involved in postsynaptic actin cytoskeleton organization; regulation of heart rate by chemical signal; and regulation of ventricular cardiac muscle cell membrane repolarization. Located in Z disc; mitochondrion; and sarcoplasmic reticulum membrane. Colocalizes with T-tubule and caveola. Is expressed in several structures, including brain; gallbladder; genitourinary system; spinal cord; and trachea. Human ortholog(s) of this gene implicated in nephrotic syndrome type 22. Orthologous to human NOS1AP (nitric oxide synthase 1 adaptor protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 24.0), cortex adult (RPKM 18.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Nos1ap in Genome Data Viewer
Location:
1 H3; 1 76.84 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170143039..170417371, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170315467..170589849, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7694 Neighboring gene spermatogenesis associated 46 Neighboring gene STARR-seq mESC enhancer starr_02991 Neighboring gene STARR-seq mESC enhancer starr_02992 Neighboring gene STARR-seq mESC enhancer starr_02993 Neighboring gene predicted gene, 46171 Neighboring gene STARR-seq mESC enhancer starr_02995 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene olfactomedin-like 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Development and persistence of long-lasting behavioral sensitization to cocaine in female mice: role of the nNOS gene. Balda MA, et al. Neuropharmacology, 2009 Mar. PMID 19114050
  2. CAPON expression in skeletal muscle is regulated by position, repair, NOS activity, and dystrophy. Ségalat L, et al. Exp Cell Res, 2005 Jan 15. PMID 15561099
  3. Inducible over-expression of cardiac Nos1ap causes short QT syndrome in transgenic mice. Jänsch M, et al. FEBS Open Bio, 2023 Jan. PMID 36352324, Free PMC Article
  4. Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders. Freudenberg F, et al. EBioMedicine, 2021 Sep. PMID 34455393, Free PMC Article
  5. Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice. Sugiyama K, et al. Int Heart J, 2016 May 25. PMID 27170476

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cardiac muscle-restricted partial loss of Nos1ap expression has limited but significant impact on electrocardiographic features.
    Title: Cardiac muscle-restricted partial loss of Nos1ap expression has limited but significant impact on electrocardiographic features.
  2. Disrupting the nNOS/NOS1AP interaction in the medial prefrontal cortex impairs social recognition and spatial working memory in mice.
    Title: Disrupting the nNOS/NOS1AP interaction in the medial prefrontal cortex impairs social recognition and spatial working memory in mice.
  3. Inducible over-expression of cardiac Nos1ap causes short QT syndrome in transgenic mice.
    Title: Inducible over-expression of cardiac Nos1ap causes short QT syndrome in transgenic mice.
  4. Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.
    Title: Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice.
  5. Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders.
    Title: Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders.
  6. CAPON Is a Critical Protein in Synaptic Molecular Networks in the Prefrontal Cortex of Mood Disorder Patients and Contributes to Depression-Like Behavior in a Mouse Model.
    Title: CAPON Is a Critical Protein in Synaptic Molecular Networks in the Prefrontal Cortex of Mood Disorder Patients and Contributes to Depression-Like Behavior in a Mouse Model.
  7. nNOS-CAPON interaction may function via regulating structural neuroplasticity, rather than neuroprotection
    Title: Dissociating nNOS (Neuronal NO Synthase)-CAPON (Carboxy-Terminal Postsynaptic Density-95/Discs Large/Zona Occludens-1 Ligand of nNOS) Interaction Promotes Functional Recovery After Stroke via Enhanced Structural Neuroplasticity.
  8. In models of Alzheimer's disease, increased nNOS-CAPON interaction was detected after treatment with amyloid-beta in vitro, and a similar change was found in the hippocampus of APP/PS1 mice (a transgenic mouse model of Alzheimer's disease), compared with age-matched background mice in vivo.
    Title: nNOS-CAPON interaction mediates amyloid-β-induced neurotoxicity, especially in the early stages.
  9. CAPON accumulated in the hippocampal pyramidal cell layer in the App(NL-G-F) -knock-in (KI) brain. In a model of Alzheimer's disease, CAPON overexpression produced significant hippocampal atrophy and caspase3-dependent neuronal cell death in the CAPON-expressing hippocampus, suggesting that CAPON accumulation increases neurodegeneration.
    Title: Tau binding protein CAPON induces tau aggregation and neurodegeneration.
  10. results hint towards an involvement of NOS-I/NOS1AP interaction in the regulation of dendritic spine plasticity
    Title: Interaction of NOS1AP with the NOS-I PDZ domain: Implications for schizophrenia-related alterations in dendritic morphology.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables nitric-oxide synthase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nitric-oxide synthase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in postsynaptic actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of heart rate by chemical signal IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of heart rate by chemical signal ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ventricular cardiac muscle cell membrane repolarization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with T-tubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with caveola IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in podosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
Names
C-terminal PDZ domain ligand of neuronal nitric oxide synthase
C-terminal PDZ ligand of neuronal nitric oxide synthase protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109985.3 → NP_001103455.1  carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform 1

    See identical proteins and their annotated locations for NP_001103455.1

    Status: VALIDATED

    Source sequence(s)
    AC119431, AC125017, AC125021
    Consensus CDS
    CCDS48438.1
    UniProtKB/Swiss-Prot
    E9Q7B9, Q80TZ6, Q9D3A8
    Related
    ENSMUSP00000125251.2, ENSMUST00000160456.8
    Conserved Domains (1) summary
    cd01270
    Location:2 → 180
    PTB_CAPON-like; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) Phosphotyrosine-binding (PTB) domain

RNA

  1. NR_154593.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC119431, AC125017

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170143039..170417371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_027528.2: Suppressed sequence

    Description
    NM_027528.2: This RefSeq was removed because it is thought to be partial and there is insufficient support for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D3A8.3 GenPept UniProtKB/Swiss-Prot:Q9D3A8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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