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Ggnbp1 gametogenetin binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 70772, updated on 2-Nov-2024

Summary

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Official Symbol
Ggnbp1provided by MGI
Official Full Name
gametogenetin binding protein 1provided by MGI
Primary source
MGI:MGI:3055306
See related
Ensembl:ENSMUSG00000048731 AllianceGenome:MGI:3055306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mdf; 0610031G08Rik
Summary
Involved in mitochondrial fission. Located in Golgi apparatus; mitochondrial intermembrane space; and plasma membrane. Is expressed in ductus deferens; epididymis; jejunum; and testis. Orthologous to human GGNBP1 (gametogenetin binding protein 1 (pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 178.0) and kidney adult (RPKM 10.5) See more
Orthologs
human all
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Genomic context

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See Ggnbp1 in Genome Data Viewer
Location:
17 A3.3; 17 13.6 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27237009..27255352)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27018035..27036378)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene synaptic Ras GTPase activating protein 1 homolog (rat) Neighboring gene microRNA 3083b Neighboring gene microRNA 3083 Neighboring gene STARR-positive B cell enhancer ABC_E7502 Neighboring gene zinc finger and BTB domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27137073-27137182 Neighboring gene STARR-positive B cell enhancer ABC_E11633 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27164461-27164644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27165231-27165340 Neighboring gene STARR-seq mESC enhancer starr_42142 Neighboring gene BCL2-antagonist/killer 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27193173-27193441 Neighboring gene inositol 1,4,5-triphosphate receptor 3 Neighboring gene microRNA 7677 Neighboring gene inositol 1,4,5-triphosphate receptor 3, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GGNBP1 ensures proper spermiogenesis in response to stress in mice. Han T, et al. Biochem Biophys Res Commun, 2020 May 7. PMID 32139124
  2. A novel potential role for gametogenetin-binding protein 1 (GGNBP1) in mitochondrial morphogenesis during spermatogenesis in mice. Aihara T, et al. Biol Reprod, 2009 Apr. PMID 19208545
  3. Identification and characterization of a novel testicular germ cell-specific gene Ggnbp1. Zhou Y, et al. Mol Reprod Dev, 2005 Mar. PMID 15625700
  4. Germ-cell specific protein gametogenetin protein 2 (GGN2), expression in the testis, and association with intracellular membrane. Zhao Q, et al. Mol Reprod Dev, 2005 Sep. PMID 15892049
  5. Mouse Dfa is a repressor of TATA-box promoters and interacts with the Abt1 activator of basal transcription. Brower CS, et al. J Biol Chem, 2010 May 28. PMID 20356838, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GGNBP1 ensures proper spermiogenesis in response to stress in mice.
    Title: GGNBP1 ensures proper spermiogenesis in response to stress in mice.
  2. GGNBP1 is involved in spermatogenesis by modifying mitochondrial dynamics and morphology.
    Title: A novel potential role for gametogenetin-binding protein 1 (GGNBP1) in mitochondrial morphogenesis during spermatogenesis in mice.
  3. A testicular germ cell-specific protein interacting with GGN1. The protein seems to associate with the membrane system in the germ cell.
    Title: Identification and characterization of a novel testicular germ cell-specific gene Ggnbp1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: Zbtb9

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
gametogenetin-binding protein 1
Names
deubiquitinating enzyme Usp15
gametogenin binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001251881.1 → NP_001238810.1  gametogenetin-binding protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon and includes two alternate exons in the 5' UTR and CDS, compared to variant 1. It encodes isoform b, which is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AA388242, CF585840, CO041745
    Consensus CDS
    CCDS57061.1
    UniProtKB/TrEMBL
    D3Z3W4
    Related
    ENSMUSP00000113880.2, ENSMUST00000122106.9
    Conserved Domains (1) summary
    pfam14836
    Location:173 → 260
    Ubiquitin_3; Ubiquitin-like domain

  2. NM_027544.2 → NP_081820.2  gametogenetin-binding protein 1 isoform a

    See identical proteins and their annotated locations for NP_081820.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK077129, AY141192, BB018101
    Consensus CDS
    CCDS28559.1
    UniProtKB/Swiss-Prot
    B9WZ58, Q6K1E7, Q8C5T9
    Related
    ENSMUSP00000051800.7, ENSMUST00000053683.7
    Conserved Domains (1) summary
    pfam14836
    Location:281 → 368
    Ubiquitin_3; Ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    27237009..27255352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6K1E7.2 GenPept UniProtKB/Swiss-Prot:Q6K1E7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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