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Akr1cl aldo-keto reductase family 1, member C-like [ Mus musculus (house mouse) ]

Gene ID: 70861, updated on 2-Nov-2024

Summary

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Official Symbol
Akr1clprovided by MGI
Official Full Name
aldo-keto reductase family 1, member C-likeprovided by MGI
Primary source
MGI:MGI:1918111
See related
Ensembl:ENSMUSG00000025955 AllianceGenome:MGI:1918111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921521F21Rik
Summary
Predicted to enable several functions, including geranylgeranyl reductase activity; oxidoreductase activity, acting on CH-OH group of donors; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including doxorubicin metabolic process; progesterone metabolic process; and prostaglandin metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in adrenal medulla; interstitium of the testis; seminiferous cord; testis; and urogenital ridge. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to human AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in ovary adult (RPKM 219.7), adrenal adult (RPKM 99.4) and 1 other tissue See more
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Genomic context

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See Akr1cl in Genome Data Viewer
Location:
1 C2; 1 32.8 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65052237..65071918, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65013078..65032759, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L10A, pseudogene 1 Neighboring gene predicted gene, 24788 Neighboring gene translation machinery associated 16 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01169 Neighboring gene STARR-seq mESC enhancer starr_01170 Neighboring gene STARR-seq mESC enhancer starr_01171 Neighboring gene crystallin, gamma E Neighboring gene crystallin, gamma D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Akr1cl gene product is a prostaglandin D(2) 11-ketoreductase with strict substrate specificity. Endo S, et al. Arch Biochem Biophys, 2019 Oct 15. PMID 31479646
  2. AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway. Wang X, et al. Mol Med Rep, 2021 Dec. PMID 34590152, Free PMC Article
  3. WT1-mediated gene regulation in early urogenital ridge development. Klattig J, et al. Sex Dev, 2007. PMID 18391535
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AKR1C1 alleviates LPSinduced ALI in mice by activating the JAK2/STAT3 signaling pathway.
    Title: AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.
  2. Akr1cl protein is an NADPH-dependent prostaglandin D2 11-ketoreductase that catalyzes the conversion of prostagland D2 to 9alpha,11beta-prostaglandin F2.
    Title: Mouse Akr1cl gene product is a prostaglandin D(2) 11-ketoreductase with strict substrate specificity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables Delta4-3-oxosteroid 5beta-reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables aldo-keto reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase (B-specific) activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables bile acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bile acid binding ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables geranylgeranyl reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables ketoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ketosteroid monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in daunorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in doxorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in progesterone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aldo-keto reductase family 1, member C-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310617.1 → NP_001297546.1  aldo-keto reductase family 1, member C-like isoform 2

    See identical proteins and their annotated locations for NP_001297546.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' coding exon compared to variant 1, which causes translation initiation from a downstream AUG. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK014937, AK135492, BX634817, CJ052308
    Consensus CDS
    CCDS78599.1
    UniProtKB/TrEMBL
    G3XA14, Q9D5U2
    Related
    ENSMUSP00000124333.2, ENSMUST00000162800.8
    Conserved Domains (2) summary
    COG0656
    Location:2 → 278
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:7 → 266
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  2. NM_027582.4 → NP_081858.2  aldo-keto reductase family 1, member C-like isoform 1

    See identical proteins and their annotated locations for NP_081858.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK135492, BX634817, CJ052308
    Consensus CDS
    CCDS48282.1
    UniProtKB/TrEMBL
    Q3UXL1, Q80W25
    Related
    ENSMUSP00000063309.6, ENSMUST00000069142.12
    Conserved Domains (2) summary
    COG0656
    Location:4 → 309
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:14 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    65052237..65071918 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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