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Dmrtc1a DMRT-like family C1a [ Mus musculus (house mouse) ]

Gene ID: 70887, updated on 2-Nov-2024

Summary

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Official Symbol
Dmrtc1aprovided by MGI
Official Full Name
DMRT-like family C1aprovided by MGI
Primary source
MGI:MGI:1918137
See related
Ensembl:ENSMUSG00000031323 AllianceGenome:MGI:1918137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DMRTC1; Dmrt8.1; 1700030H14Rik; 4921520P21Rik
Summary
Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spinal cord. Orthologous to several human genes including DMRTC1 (DMRT like family C1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 10.0), genital fat pad adult (RPKM 7.3) and 7 other tissues See more
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Genomic context

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See Dmrtc1a in Genome Data Viewer
Location:
X D; X 45.79 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (101946822..101953753, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (102903216..102910145, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700031F05 gene Neighboring gene STARR-seq mESC enhancer starr_47679 Neighboring gene predicted pseudogene 9133 Neighboring gene family with sequence similarity 236, member E Neighboring gene family with sequence similarity 236, member C Neighboring gene predicted pseudogene 5126

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Male-biased expression of X-chromosomal DM domain-less Dmrt8 genes in the mouse. Veith AM, et al. Genomics, 2006 Aug. PMID 16488114
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dmrt8.1 mRNA was detected in Sertoli cells by in situ hybridization.
    Title: Male-biased expression of X-chromosomal DM domain-less Dmrt8 genes in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
doublesex- and mab-3-related transcription factor C1
Names
doublesex and mab-3 related transcription factor 8.1
likely ortologue to human doublesex-and mab-3-related transcription factor C1 (Dmrtc1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038616.2 → NP_001033705.2  doublesex- and mab-3-related transcription factor C1 isoform c

    See identical proteins and their annotated locations for NP_001033705.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two 5' exons and an internal segment in the 3' region, but has an alternate 5' sequence, as compared to variant 1. The resulting isoform (c) is shorter and has different N- and C-termini, as compared to isoform a.
    Source sequence(s)
    AK006548, AL773565, BB310814, BC147175, DQ316774
    Consensus CDS
    CCDS53161.1
    UniProtKB/Swiss-Prot
    B1AX31, B1AX32, Q2PMY0, Q9D5U3, Q9D9R7
    Related
    ENSMUSP00000113569.2, ENSMUST00000121197.8
    Conserved Domains (1) summary
    pfam15791
    Location:68 → 180
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

  2. NM_027591.3 → NP_081867.1  doublesex- and mab-3-related transcription factor C1 isoform a

    See identical proteins and their annotated locations for NP_081867.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK014934, AL773565
    Consensus CDS
    CCDS30327.1
    UniProtKB/TrEMBL
    B1AX33, B1AX34
    Related
    ENSMUSP00000033686.2, ENSMUST00000033686.2
    Conserved Domains (1) summary
    pfam15791
    Location:113 → 190
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

  3. NM_029378.2 → NP_083654.1  doublesex- and mab-3-related transcription factor C1 isoform b

    See identical proteins and their annotated locations for NP_083654.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two 5' exons but has an alternate 5' sequence, as compared to variant 1. The resulting isoform (b) is shorter and has a different N-terminus, as compared to isoform a.
    Source sequence(s)
    BB310814, DQ316773
    Consensus CDS
    CCDS53162.1
    UniProtKB/Swiss-Prot
    Q9D9R7
    Related
    ENSMUSP00000112572.2, ENSMUST00000120808.8
    Conserved Domains (1) summary
    pfam15791
    Location:68 → 145
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    101946822..101953753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318619.3 → XP_017174108.1  doublesex- and mab-3-related transcription factor C1 isoform X2

    UniProtKB/TrEMBL
    B1AX33
    Conserved Domains (1) summary
    pfam15791
    Location:73 → 187
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2

  2. XM_006528280.5 → XP_006528343.1  doublesex- and mab-3-related transcription factor C1 isoform X1

    UniProtKB/TrEMBL
    B1AX33
    Related
    ENSMUSP00000112458.2, ENSMUST00000119624.8
    Conserved Domains (1) summary
    pfam15791
    Location:112 → 226
    DMRT-like; Doublesex-and mab-3-related transcription factor C1 and C2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D9R7.2 GenPept UniProtKB/Swiss-Prot:Q9D9R7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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