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TLE3 TLE family member 3, transcriptional corepressor [ Homo sapiens (human) ]

Gene ID: 7090, updated on 7-Apr-2024

Summary

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Official Symbol
TLE3provided by HGNC
Official Full Name
TLE family member 3, transcriptional corepressorprovided by HGNC
Primary source
HGNC:HGNC:11839
See related
Ensembl:ENSG00000140332 MIM:600190; AllianceGenome:HGNC:11839
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ESG; ESG3; GRG3; HsT18976
Summary
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in bone marrow (RPKM 20.9), prostate (RPKM 8.6) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
15q23
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (70047790..70097917, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (67870017..67920141, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (70340129..70390256, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9666 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:70282987-70283875 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70292527-70293028 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70307241-70307744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9667 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_40838 Neighboring gene uncharacterized LOC124903518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70324572-70325184 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70325185-70325795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70349697-70350197 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70359676-70360176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70360177-70360677 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70363742-70364242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70370658-70371264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70371265-70371871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:70374946-70375494 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70380981-70381568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6603 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6604 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr15:70390514-70391488 Neighboring gene microRNA 629 Neighboring gene VISTA enhancer hs359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70402651-70403162 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:70403675-70404186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70404187-70404696 Neighboring gene Sharpr-MPRA regulatory region 6929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9672 Neighboring gene uncharacterized LOC107984734 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:70432131-70432636 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:70433141-70433644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70472929-70473512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70473513-70474096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70479256-70479756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:70482961-70483463 Neighboring gene RNA, U6 small nuclear 745, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of predictive markers of the therapeutic effect of eribulin chemotherapy for locally advanced or metastatic breast cancer. Kashiwagi S, et al. BMC Cancer, 2017 Aug 31. PMID 28859615, Free PMC Article
  2. TLE3 expression is associated with sensitivity to taxane treatment in ovarian carcinoma. Samimi G, et al. Cancer Epidemiol Biomarkers Prev, 2012 Feb. PMID 22194527
  3. Angiosarcoma: a study of 98 cases with immunohistochemical evaluation of TLE3, a recently described marker of potential taxane responsiveness. Shon W, et al. J Cutan Pathol, 2011 Dec. PMID 22050093
  4. Splice variants of TLE family genes and up-regulation of a TLE3 isoform in prostate tumors. Nakaya HI, et al. Biochem Biophys Res Commun, 2007 Dec 28. PMID 18273443
  5. Antisense intronic non-coding RNA levels correlate to the degree of tumor differentiation in prostate cancer. Reis EM, et al. Oncogene, 2004 Aug 26. PMID 15221013

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
    Title: The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
  2. HHEX suppresses advanced thyroid cancer by interacting with TLE3.
    Title: HHEX suppresses advanced thyroid cancer by interacting with TLE3.
  3. Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
    Title: Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
  4. Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
    Title: Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
  5. vour findings reveal a mechanistic link between TLE3 and GR-mediated resistance to AR inhibitors in human prostate cancer
    Title: TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth.
  6. RNF6-mediated ubiquitination and degradation of TLE3 activates the Wnt/beta-catenin pathway in colorectal carcinogenesis
    Title: RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.
  7. Patients with TLE3-negative tumors displayed poorer outcomes regarding progression-free survival than patients with TLE3-positive tumors when prognosis within the group of patients with triple-negative breast cancer (TNBC) lesions was analyzed. In contrast, no such difference in prognosis was found in a comparison of TLE-3 positive/negative patients in the group of all patients.
    Title: Identification of predictive markers of the therapeutic effect of eribulin chemotherapy for locally advanced or metastatic breast cancer.
  8. Wnt signaling pathway inactivates the TLE3 co-repressor via HECT E3 ubiquitin ligase Hyd/UBR5 ubiquitination.
    Title: Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.
  9. Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744.
    Title: MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling.
  10. Increased adipose tissue (AT) TLE3 in subjects with type 2 diabetes and in AT from high fat diet and PPARgamma knockout mice suggest that TLE3 may play an adaptive regulatory role that improves AT function under decreased PPARgamma expression
    Title: Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Genome-wide association study of lung function phenotypes in a founder population.
EBI GWAS Catalog
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39460, KIAA1547

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in animal organ morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transducin-like enhancer protein 3
Names
enhancer of split groucho 3
enhancer of split groucho-like protein 3
transducin like enhancer of split 3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
transducin-like enhancer of split 3, homolog of Drosophila E(sp1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105192.3 → NP_001098662.1  transducin-like enhancer protein 3 isoform b

    See identical proteins and their annotated locations for NP_001098662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, AK315058, BC043247, BM676381
    Consensus CDS
    CCDS45294.1
    UniProtKB/TrEMBL
    Q6PRX3
    Related
    ENSP00000394717.3, ENST00000451782.7
    Conserved Domains (3) summary
    cd00200
    Location:481 → 766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486 → 525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  2. NM_001282979.2 → NP_001269908.1  transducin-like enhancer protein 3 isoform e

    See identical proteins and their annotated locations for NP_001269908.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses two alternate in-frame splice sites in the 3' coding region compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, AY583459, BC043247, BM676381, M99438
    Consensus CDS
    CCDS61692.1
    UniProtKB/TrEMBL
    Q6PRX3
    Related
    ENSP00000453083.1, ENST00000557997.5
    Conserved Domains (3) summary
    cd00200
    Location:476 → 761
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:481 → 520
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  3. NM_001282980.2 → NP_001269909.1  transducin-like enhancer protein 3 isoform d

    See identical proteins and their annotated locations for NP_001269909.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, BC043247, BM676381
    Consensus CDS
    CCDS61691.1
    UniProtKB/TrEMBL
    Q6PRX2
    Related
    ENSP00000453435.1, ENST00000558379.5
    Conserved Domains (3) summary
    cd00200
    Location:479 → 764
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:484 → 523
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  4. NM_001282981.2 → NP_001269910.1  transducin-like enhancer protein 3 isoform f

    See identical proteins and their annotated locations for NP_001269910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 1. These differences result in a novel 5' coding region and 5' UTR compared to variant 1. The encoded isoform (f) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC068327, AK298482, BM676381, BP373048
    Consensus CDS
    CCDS61689.1
    UniProtKB/TrEMBL
    H0YKT5
    Related
    ENSP00000415057.3, ENST00000440567.7
    Conserved Domains (3) summary
    cd00200
    Location:474 → 759
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:479 → 518
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:2 → 126
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  5. NM_001282982.2 → NP_001269911.1  transducin-like enhancer protein 3 isoform g

    See identical proteins and their annotated locations for NP_001269911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents the use of an alternate promoter and has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon compared to variant 1. The encoded isoform (g) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, AK096779, BM676381
    UniProtKB/TrEMBL
    B3KUA2
    Conserved Domains (3) summary
    cd00200
    Location:411 → 696
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:416 → 455
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1 → 77
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  6. NM_005078.4 → NP_005069.2  transducin-like enhancer protein 3 isoform a

    See identical proteins and their annotated locations for NP_005069.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB046767, AC026583, AC068327, BC043247, BM676381, M99438
    Consensus CDS
    CCDS45293.1
    UniProtKB/Swiss-Prot
    B4DPT0, E9PD64, F8W964, Q04726, Q6PI57, Q8IVV6, Q8WVR2, Q9HCM5
    UniProtKB/TrEMBL
    Q6PRX2
    Related
    ENSP00000452871.1, ENST00000558939.5
    Conserved Domains (3) summary
    cd00200
    Location:484 → 769
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:489 → 528
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  7. NM_020908.3 → NP_065959.1  transducin-like enhancer protein 3 isoform c

    See identical proteins and their annotated locations for NP_065959.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AB046767, AC026583, AC068327, BC043247, BM676381
    Consensus CDS
    CCDS58375.1
    UniProtKB/TrEMBL
    Q6PRX2
    Related
    ENSP00000319233.8, ENST00000317509.12
    Conserved Domains (4) summary
    cd00200
    Location:472 → 757
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05109
    Location:251 → 460
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00039
    Location:477 → 516
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    70047790..70097917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432993.1 → XP_047288949.1  transducin-like enhancer protein 3 isoform X14

  2. XM_047432992.1 → XP_047288948.1  transducin-like enhancer protein 3 isoform X12

  3. XM_011521983.4 → XP_011520285.1  transducin-like enhancer protein 3 isoform X13

    UniProtKB/TrEMBL
    Q6PRX2
    Conserved Domains (4) summary
    COG2319
    Location:406 → 691
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:405 → 690
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:410 → 449
    7WD40; WD40 repeat [structural motif]

  4. XM_011521982.4 → XP_011520284.1  transducin-like enhancer protein 3 isoform X11

    UniProtKB/TrEMBL
    Q6PRX2
    Conserved Domains (4) summary
    COG2319
    Location:411 → 696
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:410 → 695
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 124
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:415 → 454
    7WD40; WD40 repeat [structural motif]

  5. XM_006720665.5 → XP_006720728.1  transducin-like enhancer protein 3 isoform X16

    UniProtKB/TrEMBL
    Q6PRX3
    Conserved Domains (3) summary
    cd00200
    Location:475 → 760
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:480 → 519
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  6. XM_011521980.4 → XP_011520282.1  transducin-like enhancer protein 3 isoform X7

    UniProtKB/TrEMBL
    Q6PRX2
    Conserved Domains (3) summary
    cd00200
    Location:483 → 768
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:488 → 527
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  7. XM_005254633.4 → XP_005254690.1  transducin-like enhancer protein 3 isoform X17

    See identical proteins and their annotated locations for XP_005254690.1

    UniProtKB/TrEMBL
    Q6PRX2
    Conserved Domains (3) summary
    cd00200
    Location:467 → 752
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:472 → 511
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  8. XM_011521977.4 → XP_011520279.1  transducin-like enhancer protein 3 isoform X2

    UniProtKB/TrEMBL
    Q6PRX2
    Conserved Domains (3) summary
    cd00200
    Location:493 → 778
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:498 → 537
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 142
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  9. XM_005254628.5 → XP_005254685.1  transducin-like enhancer protein 3 isoform X10

    UniProtKB/TrEMBL
    Q6PRX2
    Conserved Domains (3) summary
    cd00200
    Location:477 → 762
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:482 → 521
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  10. XM_005254625.5 → XP_005254682.1  transducin-like enhancer protein 3 isoform X8

    UniProtKB/TrEMBL
    Q6PRX2
    Conserved Domains (4) summary
    cd00200
    Location:482 → 767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam05109
    Location:261 → 470
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00039
    Location:487 → 526
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  11. XM_005254623.5 → XP_005254680.1  transducin-like enhancer protein 3 isoform X5

    UniProtKB/TrEMBL
    Q6PRX3
    Conserved Domains (3) summary
    cd00200
    Location:486 → 771
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:491 → 530
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  12. XM_005254622.6 → XP_005254679.1  transducin-like enhancer protein 3 isoform X3

    UniProtKB/TrEMBL
    Q6PRX3
    Conserved Domains (3) summary
    cd00200
    Location:491 → 776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:496 → 535
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  13. XM_011521978.4 → XP_011520280.1  transducin-like enhancer protein 3 isoform X4

    UniProtKB/TrEMBL
    Q6PRX2
    Conserved Domains (3) summary
    cd00200
    Location:489 → 774
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:494 → 533
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  14. XM_011521976.4 → XP_011520278.1  transducin-like enhancer protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011520278.1

    UniProtKB/TrEMBL
    H0YL70, Q6PRX2
    Related
    ENSP00000453081.1, ENST00000559929.5
    Conserved Domains (3) summary
    cd00200
    Location:494 → 779
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:499 → 538
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  15. XM_011521979.4 → XP_011520281.1  transducin-like enhancer protein 3 isoform X6

    See identical proteins and their annotated locations for XP_011520281.1

    UniProtKB/TrEMBL
    H0YNT2
    Related
    ENSP00000453760.1, ENST00000559048.5
    Conserved Domains (3) summary
    cd00200
    Location:422 → 707
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:427 → 466
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:1 → 76
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  16. XM_011521981.3 → XP_011520283.1  transducin-like enhancer protein 3 isoform X9

    UniProtKB/TrEMBL
    Q6PRX2
    Conserved Domains (4) summary
    COG2319
    Location:488 → 747
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:494 → 738
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:1 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:499 → 538
    7WD40; WD40 repeat [structural motif]

  17. XM_017022532.3 → XP_016878021.1  transducin-like enhancer protein 3 isoform X15

    UniProtKB/TrEMBL
    H0YLI3
    Related
    ENSP00000453373.1, ENST00000561453.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    67870017..67920141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378731.1 → XP_054234706.1  transducin-like enhancer protein 3 isoform X14

  2. XM_054378729.1 → XP_054234704.1  transducin-like enhancer protein 3 isoform X12

  3. XM_054378730.1 → XP_054234705.1  transducin-like enhancer protein 3 isoform X13

  4. XM_054378728.1 → XP_054234703.1  transducin-like enhancer protein 3 isoform X11

  5. XM_054378733.1 → XP_054234708.1  transducin-like enhancer protein 3 isoform X16

  6. XM_054378724.1 → XP_054234699.1  transducin-like enhancer protein 3 isoform X7

  7. XM_054378734.1 → XP_054234709.1  transducin-like enhancer protein 3 isoform X17

  8. XM_054378719.1 → XP_054234694.1  transducin-like enhancer protein 3 isoform X2

  9. XM_054378727.1 → XP_054234702.1  transducin-like enhancer protein 3 isoform X10

  10. XM_054378725.1 → XP_054234700.1  transducin-like enhancer protein 3 isoform X8

  11. XM_054378722.1 → XP_054234697.1  transducin-like enhancer protein 3 isoform X5

  12. XM_054378720.1 → XP_054234695.1  transducin-like enhancer protein 3 isoform X3

  13. XM_054378721.1 → XP_054234696.1  transducin-like enhancer protein 3 isoform X4

  14. XM_054378718.1 → XP_054234693.1  transducin-like enhancer protein 3 isoform X1

    UniProtKB/TrEMBL
    H0YL70

  15. XM_054378723.1 → XP_054234698.1  transducin-like enhancer protein 3 isoform X6

  16. XM_054378726.1 → XP_054234701.1  transducin-like enhancer protein 3 isoform X9

  17. XM_054378732.1 → XP_054234707.1  transducin-like enhancer protein 3 isoform X15

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04726.2 GenPept UniProtKB/Swiss-Prot:Q04726

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