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PAPPA2 pappalysin 2 [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 709193, updated on 17-Aug-2024

Summary

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Official Symbol
PAPPA2provided by VGNC
Official Full Name
pappalysin 2provided by VGNC
Primary source
VGNC:VGNC:75603
See related
Ensembl:ENSMMUG00000023214
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See PAPPA2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
23
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 1 NC_041754.1 (33782176..34087601)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 1 NC_027893.1 (190717866..191025013, complement)

Chromosome 1 - NC_041754.1Genomic Context describing neighboring genes Neighboring gene COP1 E3 ubiquitin ligase Neighboring gene histone H3.3 Neighboring gene 60S ribosomal protein L13 pseudogene Neighboring gene protein tyrosine phosphatase type IVA 1-like Neighboring gene astrotactin 1 Neighboring gene microRNA mir-488 Neighboring gene uncharacterized LOC106994726 Neighboring gene BMP/retinoic acid inducible neural specific 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pappalysin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041754.1 Reference Mmul_10 Primary Assembly

    Range
    33782176..34087601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015123561.2 → XP_014979047.2  pappalysin-2

    UniProtKB/TrEMBL
    F7EAV1
    Related
    ENSMMUP00000030555.4, ENSMMUT00000032654.4
    Conserved Domains (6) summary
    cd00033
    Location:1524 → 1590
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00004
    Location:1721 → 1757
    NL; Domain found in Notch and Lin-12
    TIGR02232
    Location:1111 → 1150
    myxo_disulf_rpt; Myxococcus cysteine-rich repeat
    cd04275
    Location:595 → 830
    ZnMc_pappalysin_like; Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. ...
    pfam00084
    Location:1463 → 1520
    Sushi; Sushi repeat (SCR repeat)
    pfam13385
    Location:281 → 432
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
Nucleotide Protein
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