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Trim69 tripartite motif-containing 69 [ Mus musculus (house mouse) ]

Gene ID: 70928, updated on 2-Nov-2024

Summary

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Official Symbol
Trim69provided by MGI
Official Full Name
tripartite motif-containing 69provided by MGI
Primary source
MGI:MGI:1918178
See related
Ensembl:ENSMUSG00000033368 AllianceGenome:MGI:1918178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trif; Rnf36; Trimless; 4921519C19Rik
Summary
Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in innate immune response and protein localization to centrosome. Predicted to be located in nuclear speck. Predicted to be active in centrosome and cytoplasm. Is expressed in central nervous system. Orthologous to human TRIM69 (tripartite motif containing 69). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 46.9) See more
Orthologs
human all
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Genomic context

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See Trim69 in Genome Data Viewer
Location:
2 E5; 2 60.55 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121991189..122009503)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122160708..122179022)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit J1 Neighboring gene SPG11, spatacsin vesicle trafficking associated Neighboring gene STARR-seq mESC enhancer starr_05546 Neighboring gene protein associated with topoisomerase II homolog 2 (yeast) Neighboring gene STARR-positive B cell enhancer ABC_E512 Neighboring gene STARR-seq mESC enhancer starr_05550 Neighboring gene beta-2 microglobulin Neighboring gene telomere repeat binding bouquet formation protein 2 Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The testis-specifically expressed gene Trim69 is not essential for fertility in mice. He X, et al. J Biomed Res, 2020 Aug 21. PMID 33273151, Free PMC Article
  2. Targeting Trim69 alleviates high fat diet (HFD)-induced hippocampal injury in mice by inhibiting apoptosis and inflammation through ASK1 inactivation. Li LJ, et al. Biochem Biophys Res Commun, 2019 Aug 6. PMID 31178136
  3. A novel member of the RBCC family, Trif, expressed specifically in the spermatids of mouse testis. Shyu HW, et al. Mech Dev, 2001 Oct. PMID 11578878
  4. Forced expression of RNF36 induces cell apoptosis. Shyu HW, et al. Exp Cell Res, 2003 Jul 15. PMID 12837286
  5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Trim69 might be a functionally essential inhibitor of ASK1 activation during the pathogenesis of hippocampal inflammation and apoptosis
    Title: Targeting Trim69 alleviates high fat diet (HFD)-induced hippocampal injury in mice by inhibiting apoptosis and inflammation through ASK1 inactivation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to centrosome IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM69
Names
RFP-like (B30.2) domain protein
RING finger B-box coiled-coil transcription factor
RING-type E3 ubiquitin transferase TRIM69
ring finger protein 36
testis-specific RING finger protein
tripartite motif-containing protein 69
NP_001366298.1
NP_536771.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379369.1 → NP_001366298.1  E3 ubiquitin-protein ligase TRIM69 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL844573, AL845457
    Conserved Domains (4) summary
    PLN03208
    Location:17 → 134
    PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional
    COG1196
    Location:136 → 272
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl02614
    Location:294 → 479
    SPRY; SPRY domain
    cl17238
    Location:21 → 65
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. NM_080510.3 → NP_536771.2  E3 ubiquitin-protein ligase TRIM69 isoform 1

    See identical proteins and their annotated locations for NP_536771.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL844573, AL845457
    Consensus CDS
    CCDS16655.1
    UniProtKB/Swiss-Prot
    Q80X56, Q8VHZ6
    Related
    ENSMUSP00000047627.8, ENSMUST00000036089.8
    Conserved Domains (2) summary
    cl02614
    Location:312 → 497
    SPRY; SPRY domain
    cl17238
    Location:42 → 82
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

  1. NR_166637.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL844573, AL845457

  2. NR_166638.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL844573, AL845457

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121991189..122009503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80X56.1 GenPept UniProtKB/Swiss-Prot:Q80X56

Gene LinkOut

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