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Cabyr calcium binding tyrosine phosphorylation regulated [ Mus musculus (house mouse) ]

Gene ID: 71132, updated on 2-Nov-2024

Summary

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Official Symbol
Cabyrprovided by MGI
Official Full Name
calcium binding tyrosine phosphorylation regulatedprovided by MGI
Primary source
MGI:MGI:1918382
See related
Ensembl:ENSMUSG00000024430 AllianceGenome:MGI:1918382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CBP86; FSP-2; 1700016C01Rik; 4933421A18Rik
Summary
Enables calcium ion binding activity and protein domain specific binding activity. Located in cytoplasm and sperm flagellum. Used to study male infertility. Orthologous to human CABYR (calcium binding tyrosine phosphorylation regulated). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 63.2) and cortex adult (RPKM 3.8) See more
Orthologs
human all
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Genomic context

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See Cabyr in Genome Data Viewer
Location:
18 A1; 18 6.77 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (12874141..12888203)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12740825..12755146)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene predicted gene, 41668 Neighboring gene microRNA 1948 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene oxysterol binding protein-like 1A Neighboring gene predicted gene, 52343 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:12966807-12966996 Neighboring gene predicted gene, 36439

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa. Young SA, et al. J Cell Sci, 2016 Dec 1. PMID 27802166
  2. Splicing in murine CABYR and its genomic structure. Sen B, et al. Gene, 2003 May 22. PMID 12801634
  3. Coiled-coil domain-containing 38 is required for acrosome biogenesis and fibrous sheath assembly in mice. Wang Y, et al. J Genet Genomics, 2024 Apr. PMID 37709195
  4. CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath. Li YF, et al. Reprod Biol Endocrinol, 2010 Aug 23. PMID 20731842, Free PMC Article
  5. FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. Li YF, et al. J Biol Chem, 2007 Nov 23. PMID 17855365

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. it is the role of CABYR in the formation of the fibrous sheath that is essential for male fertility.
    Title: CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa.
  2. CABYR expresses at the late stage of spermiogenesis and its isoforms oligomerize and bind with AKAPs and ropporin; which suggests that CABYR participates in the assembly of the fibrous sheath.
    Title: CABYR isoforms expressed in late steps of spermiogenesis bind with AKAPs and ropporin in mouse sperm fibrous sheath.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC130217, MGC130218

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding TAS
Traceable Author Statement
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-mediated signaling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in sperm capacitation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in sperm end piece IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sperm fibrous sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm fibrous sheath ISO
Inferred from Sequence Orthology
more info
  
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium-binding tyrosine phosphorylation-regulated protein
Names
calcium-binding protein 86
calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
testis-specific calcium-binding protein CBP86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042418.1 → NP_001035883.1  calcium-binding tyrosine phosphorylation-regulated protein isoform a

    See identical proteins and their annotated locations for NP_001035883.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' UTR, compared to variant 1. It encodes the same protein as variant 1 (isoform a).
    Source sequence(s)
    AF359385
    Consensus CDS
    CCDS37739.1
    UniProtKB/Swiss-Prot
    Q91Y41, Q91Y42, Q9D424
    Related
    ENSMUSP00000118330.2, ENSMUST00000150758.8
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

  2. NM_001042419.1 → NP_001035884.1  calcium-binding tyrosine phosphorylation-regulated protein isoform e

    See identical proteins and their annotated locations for NP_001035884.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region, compared to variant 1. The encoded isoform (e) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AF359384, BC107272
    Consensus CDS
    CCDS50224.1
    UniProtKB/TrEMBL
    A0A3Q4EGN8
    Related
    ENSMUSP00000113760.2, ENSMUST00000119108.8
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

  3. NM_001042420.1 → NP_001035885.1  calcium-binding tyrosine phosphorylation-regulated protein isoform a

    See identical proteins and their annotated locations for NP_001035885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 3' UTR, compared to variant 1. It encodes the same protein as variant 1 (isoform a).
    Source sequence(s)
    AK016856, BB017109
    Consensus CDS
    CCDS37739.1
    UniProtKB/Swiss-Prot
    Q91Y41, Q91Y42, Q9D424
    Related
    ENSMUSP00000111523.3, ENSMUST00000115857.9
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

  4. NM_027687.2 → NP_081963.1  calcium-binding tyrosine phosphorylation-regulated protein isoform a

    See identical proteins and their annotated locations for NP_081963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF359382
    Consensus CDS
    CCDS37739.1
    UniProtKB/Swiss-Prot
    Q91Y41, Q91Y42, Q9D424
    Related
    ENSMUSP00000140870.2, ENSMUST00000186263.2
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

  5. NM_181731.3 → NP_859420.2  calcium-binding tyrosine phosphorylation-regulated protein isoform c

    See identical proteins and their annotated locations for NP_859420.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AF359383, BC107272
    Consensus CDS
    CCDS50223.1
    UniProtKB/TrEMBL
    Q3KNH8
    Related
    ENSMUSP00000113131.2, ENSMUST00000121018.8
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    12874141..12888203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317979.3 → XP_017173468.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X1

    UniProtKB/Swiss-Prot
    Q91Y41, Q91Y42, Q9D424
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

  2. XM_036161276.1 → XP_036017169.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X2

    UniProtKB/TrEMBL
    Q3KNH8
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D424.1 GenPept UniProtKB/Swiss-Prot:Q9D424

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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