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Scara5 scavenger receptor class A, member 5 [ Mus musculus (house mouse) ]

Gene ID: 71145, updated on 2-Nov-2024

Summary

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Official Symbol
Scara5provided by MGI
Official Full Name
scavenger receptor class A, member 5provided by MGI
Primary source
MGI:MGI:1918395
See related
Ensembl:ENSMUSG00000022032 AllianceGenome:MGI:1918395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tesr; 4932433F15Rik; 4933425F03Rik
Summary
Enables ferritin receptor activity. Involved in several processes, including intracellular iron ion homeostasis; iron ion transmembrane transport; and protein homotrimerization. Acts upstream of or within cellular response to heat. Located in cell surface and plasma membrane. Is expressed in several structures, including eye; gonad; heart; spinal cord; and vertebral pre-cartilage condensation. Orthologous to human SCARA5 (scavenger receptor class A member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 37.1), mammary gland adult (RPKM 14.4) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Scara5 in Genome Data Viewer
Location:
14 D1; 14 34.35 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (65903852..66002275)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (65666403..65764826)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nuclear GTPase, germinal center associated Neighboring gene STARR-seq mESC enhancer starr_36976 Neighboring gene predicted gene, 30245 Neighboring gene STARR-seq mESC enhancer starr_36977 Neighboring gene predicted gene, 53863 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:66424601-66424784 Neighboring gene STARR-seq mESC enhancer starr_36982 Neighboring gene STARR-seq mESC enhancer starr_36983 Neighboring gene PDZ binding kinase Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SCARA5 plays a critical role in the commitment of mesenchymal stem cells to adipogenesis. Lee H, et al. Sci Rep, 2017 Nov 1. PMID 29093466, Free PMC Article
  2. L-ferritin binding to scara5: a new iron traffic pathway potentially implicated in retinopathy. Mendes-Jorge L, et al. PLoS One, 2014. PMID 25259650, Free PMC Article
  3. Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. Huang J, et al. J Clin Invest, 2010 Jan. PMID 20038795, Free PMC Article
  4. Interactions of ferritin with scavenger receptor class A members. Yu B, et al. J Biol Chem, 2020 Nov 13. PMID 32907880, Free PMC Article
  5. Novel scavenger receptor gene is differentially expressed in the embryonic and adult mouse testis. Sarraj MA, et al. Dev Dyn, 2005 Dec. PMID 16245330

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interactions of ferritin with scavenger receptor class A members.
    Title: Interactions of ferritin with scavenger receptor class A members.
  2. This study demonstrates that SCARA5 is a positive regulator in adipocyte lineage commitment and early adipogenesis in mesenchymal stem cells.
    Title: SCARA5 plays a critical role in the commitment of mesenchymal stem cells to adipogenesis.
  3. Scara5 was downregulated, pointing out this receptor as a potential player implicated in retinopathy and also as a possible therapeutic target.
    Title: L-ferritin binding to scara5: a new iron traffic pathway potentially implicated in retinopathy.
  4. Defects in fibroblast SCARA5 can underlie some forms of autoimmune disease.
    Title: Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor A5-deficient mice.
  5. plasma membrane protein SCARA5 can contribute to human hepatocellular carcinoma (HCC) tumorigenesis and metastasis via activation of the FAK signaling pathway.
    Title: Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling.
  6. Tesr is differentially expressed in the male vs. female embryonic and postnatal gonad, and may play a role in phagocytosis of apoptotic cells, cell-cell adhesion, and defense. [Tesr - testis expressed scavenger receptor]
    Title: Novel scavenger receptor gene is differentially expressed in the embryonic and adult mouse testis.
  7. Data show that the transferrin receptor TfR1 provided transferrin to the ureteric bud, but not to the capsule or the stroma, and that Scara5 bound serum ferritin and then stimulated its endocytosis from the cell surface with consequent iron delivery.
    Title: Scara5 is a ferritin receptor mediating non-transferrin iron delivery.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ferritin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular iron ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in iron ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein homotrimerization IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
scavenger receptor class A member 5
Names
scavenger receptor class A, member 5 (putative)
testis expressed scavenger receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168318.1 → NP_001161790.1  scavenger receptor class A member 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK016543, AK033154, BY791906
    Consensus CDS
    CCDS49523.1
    UniProtKB/Swiss-Prot
    Q8K299
    Related
    ENSMUSP00000063391.7, ENSMUST00000069226.7
    Conserved Domains (2) summary
    pfam01391
    Location:306 → 373
    Collagen; Collagen triple helix repeat (20 copies)
    pfam08496
    Location:67 → 115
    Peptidase_S49_N; Peptidase family S49 N-terminal

  2. NM_028903.2 → NP_083179.2  scavenger receptor class A member 5 isoform 1

    See identical proteins and their annotated locations for NP_083179.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK133176, BC016096
    Consensus CDS
    CCDS27214.1
    UniProtKB/Swiss-Prot
    Q8BZZ2, Q8K299, Q8R330, Q91WD6, Q9CUC3, Q9D4G8
    Related
    ENSMUSP00000022610.9, ENSMUST00000022610.15
    Conserved Domains (3) summary
    PRK09039
    Location:55 → 249
    PRK09039; peptidoglycan -binding protein
    smart00202
    Location:389 → 489
    SR; Scavenger receptor Cys-rich
    pfam01391
    Location:318 → 373
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    65903852..66002275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158851.1 → XP_036014744.1  scavenger receptor class A member 5 isoform X1

    UniProtKB/Swiss-Prot
    Q8BZZ2, Q8K299, Q8R330, Q91WD6, Q9CUC3, Q9D4G8
    Conserved Domains (3) summary
    PRK09039
    Location:55 → 249
    PRK09039; peptidoglycan -binding protein
    smart00202
    Location:389 → 489
    SR; Scavenger receptor Cys-rich
    pfam01391
    Location:318 → 373
    Collagen; Collagen triple helix repeat (20 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K299.1 GenPept UniProtKB/Swiss-Prot:Q8K299

Gene LinkOut

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